Effect of quercetin on chondrocyte phenotype and extracellular matrix expression

Gui, Zhipeng; Hu, Yue; Zhou, Yifeng; Lin, Kaili; Xu, Yinghong

doi:10.1016/s1875-5364(20)60036-x

Cited by 1 publication

(1 citation statement)

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“…Recent studies have shown the advantage of using ICA in osteochondral regeneration due to both osteogenic and chondrogenic effect, compared to other flavonoids, such as naringin and kaempferol, which presented only osteogenic effects [ 23 ]. Reports on another flavonoid, quercetin, indicated its osteogenic and chondrogenic effects, but evidence on cartilage regeneration and the mechanisms of action were limited [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in Composite Hydrogels and Scaffolds Enriched with Icariin for Osteochondral Defect Healing

Oprita

Iosăgeanu

Crăciunescu

2022

Gels

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Osteochondral structure reconstruction by tissue engineering, a challenge in regenerative medicine, requires a scaffold that ensures both articular cartilage and subchondral bone remodeling. Functional hydrogels and scaffolds present a strategy for the controlled delivery of signaling molecules (growth factors and therapeutic drugs) and are considered a promising therapeutic approach. Icariin is a pharmacologically-active small molecule of prenylated flavonol glycoside and the main bioactive flavonoid isolated from Epimedium spp. The in vitro and in vivo testing of icariin showed chondrogenic and ostseoinductive effects, comparable to bone morphogenetic proteins, and suggested its use as an alternative to growth factors, representing a low-cost, promising approach for osteochondral regeneration. This paper reviews the complex structure of the osteochondral tissue, underlining the main aspects of osteochondral defects and those specifically occurring in osteoarthritis. The significance of icariin’s structure and the extraction methods were emphasized. Studies revealing the valuable chondrogenic and osteogenic effects of icariin for osteochondral restoration were also reviewed. The review highlighted th recent state-of-the-art related to hydrogels and scaffolds enriched with icariin developed as biocompatible materials for osteochondral regeneration strategies.

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Section: Introductionmentioning

confidence: 99%