Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients

Abstract

Background: Diabetes associated with multiple metabolic problems in the body, including bone mineralization remodeling, osteoporosis and increase risk of fracture. Quercetin is natural flavonoids and according to animal studies; it has potent antioxidant, antidiabetic and protective effect against bone loss due to various causes. Objectives: explore effect of quercetin as nutritional supplement administrated orally on some bone mineralization bio-markers such as calcium, vitamin D and osteocalcin in Iraqi diabetic patients. Methods: interventional double-blind placebo randomized controlled study in which 40 patients with type 2 diabetes mellitus (age range 40-45) assigned randomly (using simple randomization) in either control (n=20) or study (n=20) group. Study group received Quercetin oral supplement as 500mg capsule once daily for three months. Venous blood was used for measuring Serum calcium, 25(OH) vitamin D and osteocalcin at base line and after 3 months. Results: After 3 months treatment with Quercetin; levels of Osteocalcin (28.1±7.6), serum calcium (9.2±1.8) and 25(OH) vitamin D (26.6±8.7) were significantly (p<0.05) higher than pretreatment values of osteocalcin (24.0±8.6); serum calcium (7.0±2.2) and 25(OH) vitamin D (20.6±7.7) and control values of serum calcium (6.8±2.0) and 25(OH) vitamin D (20.8±7.4), but not Osteocalcin (25.2±9.0). There was also significant correlation between use of quercetin; elevation of serum calcium and osteocalcin (r= 0.454; p= 0.032), indicating modulation in bone mineralization. Conclusions: Quercetin's use in diabetic patients may elevate Serum level of Calcium; 25(OH) vitamin D and may modulate bone mineralization represented by elevation of osteocalcin.

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

“…Based on its actions on bone, an interventional double-blind placebo randomised controlled study investigated the effects of quercetin supplementation on bone mineralisation biomarkers in patients with type 2 diabetes mellitus. In this study, patients receiving quercetin oral supplement at 500 mg/day for three months had higher levels of serum osteocalcin, calcium and vitamin D compared to their pretreatment values [ 28 ]. However, the direct effects of quercetin on bone in osteoporotic patients are still unconfirmed.…”

“…Quercetin is a natural dietary bioflavonoid present ubiquitously in fruits and vegetables. The reported beneficial effects of quercetin include cardioprotective [ 15 ], neuroprotective [ 16 ], gastroprotective [ 17 ], anticarcinogenic [ 18 ], antimicrobial [ 19 ], anti-atherosclerotic [ 20 ], anti-inflammatory [ 21 , 22 ], antioxidative [ 21 , 23 ], immunomodulatory [ 22 ], antihypertensive [ 24 ], anti-obesity [ 25 ], antihyperglycaemic [ 26 ], lipid-modulating [ 27 ] and bone-conserving properties [ 28 ]. Amongst these, several bioactivities of quercetin make it a potential agent for maintaining bone health.…”

Effects of Melatonin on Some Bone Mineralization Biomarkers for Overweight or Obese Perimenopause Women; A Possible Role in Osteoporosis Treatment

“…19 Despite the importance of melatonin in these biological functions, its role in diminishing osteoporosis in women in perimenopause is not fully understood. 20 In this research, melatonin is an oral supplement used for 2 months for women in perimenopause to study its effect on biochemical markers related to bones mineralization for study group, and compared to placebo, this method is similar to method done by Falah et al and Jubran et al 21,22 Melatonin administration was able to provide a rapid increase in the serum concentration of bone markers: osteocalcin, vitamin D, calcium, and CTX-1 significantly (p < 0.05) compared to control group. This is the principal endpoint in our research, and these results were different from results of many studies that found the use of melatonin has no effect on the level of osteocalcin and other measured markers.…”

Role of Polyphenols in the Metabolism of the Skeletal System in Humans and Animals – A Review

“…Welch et al (2012) concluded that habitual flavonoid intake was positively associated with bone mineral density in both the hip and spine regions. Hassan et al (2018) found a strong association between an increase in the osteocalcin and elevation in serum calcium after administration of quercetin. This may indicate modulation of bone mineralization (Ducy et al, 1996).…”

“…a major class of phytochemicals found ubiquitously in fruit and vegetables (Hardcastle et al, 2011). Hassan et al (2018) and Marwan and Saleh (2012) showed a significant correlation between the use of selected polyphenols and elevation of serum calcium, vitamin D, and osteocalcin levels as markers of modulation in bone mineralization. Based on the results of a cohort study, Hardcastle et al (2011) found a significant association between flavonoid intake and bone mineral density in the hip and lumbar spine and a negative correlation with bone-resorption markers.…”