Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus

Moriya, Shunpei; Tahara, Yu; Sasaki, Hiroyuki; Hamaguchi, Yutaro; Kuriki, Daisuke; Ishikawa, Ryosuke; Ishigooka, Jun; Shibata, Shigenobu

doi:10.1254/jphs.14071sc

Cited by 19 publications

(9 citation statements)

References 15 publications

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“…Whether this immune system response reflects hippocampal function requires further investigation. Some studies have investigated the relationship between the hippocampus and alterations in proinflammatory cytokines, circadian rhythms and psychiatric disorders such as depression [10,27]. …”

Section: Discussionmentioning

confidence: 99%

Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation

Campos

Buchaim

Silva

et al. 2017

Neuroimmunomodulation

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Objective: The clock genes Period (per) 1 and 2 are essential components in the generation and adjustment of biological circadian rhythms by the suprachiasmatic nucleus (SCN). Both genes are also rhythmically present in extrahypothalamic areas such as the hippocampus and cerebellum, considered subordinate oscillators. Several pathological conditions alter rhythmic biological phenomena, but the mechanisms behind these changes involving the clock genes are not well defined. The current study investigated changes in PER1 and PER2 immunoreactivity in the SCN, hippocampus, and cerebellum in a neuroinflammation model. Methods: Wistar rats received lipopolysaccharide (LPS) or vehicle intracerebroventricularly. The melatonin plasmatic content was quantified by ELISA to confirm the alterations in biological rhythms, and PER1 and PER2 immunoreactivities were analyzed in brain sections by immunohistochemistry. Results: In the SCN, intracerebroventricular LPS changed PER1 expression, increasing the number of PER1-immunoreactive (IR) cells at zeitgeber time (ZT) 15, decreasing it at ZT5 and ZT20 and not changing it at ZT10. LPS also induced a decrease in PER2-IR cells at ZT5, ZT10, and ZT15 but not at ZT20 in the SCN. In the hippocampus, LPS induced a decrease in PER1-IR and PER2-IR cells at both ZTs (ZT10 and ZT15). In the cerebellum, LPS increased the number of PER1-IR cells at ZT10 and decreased it at ZT15, while the number of PER2-IR cells was reduced at both ZTs. Conclusions: These results indicate that a neuroinflammatory condition leads to desynchronization of primary and subordinate brain oscillators, supporting the existence of the integration between the immune and the circadian system.

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Section: Discussionmentioning

confidence: 99%

Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation

Campos

Buchaim

Silva

et al. 2017

Neuroimmunomodulation

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“…A recent study found that quetiapine can alter clock genes expression in mice, elevating Per1, Per2 and Bmal1 mRNA expression, depending on the circadian time (Moriya, Tahara et al 2014).…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles

Abreu

Bragança²

2015

Journal of Affective Disorders

120

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“…It has also been reported that various in vitro cultures of peripheral tissues and cell lines exhibit circadian rhythms [ 2 ]. Circadian rhythms are entrained by environmental cycles, such as sunlight, food, and temperature, and by various drugs and chemicals [ 3 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

et al. 2017

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Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, and Alzheimer’s have been well studied. However, little is known about the relationships between flavonoids and the circadian clock. In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase. Transient application of some of the tested flavonoids to cultured cells induced a phase delay of the PER2::LUC rhythm at the down slope phase. In addition, continuous application of the polymethoxy flavonoids nobiletin and tangeretin increased the amplitude and lengthened the period of the PER2::LUC rhythm. The nobiletin-induced phase delay was blocked by co-treatment with U0126, an ERK inhibitor. In summary, among the tested flavonoids, polymethoxy flavones increased the amplitude, lengthened the period, and delayed the phase of the PER2::LUC circadian rhythm. Therefore, foods that contain polymethoxy flavones may have beneficial effects on circadian rhythm disorders and jet lag.

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Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus

Cited by 19 publications

References 15 publications

Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation

Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation

The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

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