Effect of quetiapine treatment on facial emotion recognition deficits in schizophrenia patients

Cabral‐Calderín, Yuranny; Quiñones, Raúl Mendoza; Garcı́a, Ana; Caballero, Antonio; Domínguez, Mayelín; Reyes, Migdyrai Martín

doi:10.1016/j.schres.2010.03.038

Cited by 6 publications

(10 citation statements)

References 10 publications

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Section: Discussionmentioning

confidence: 99%

“…However, Cabral-Calderin et al [67] did perform the Emotional Expression Multimorph Task in schizophrenic patients using morphed images (changing facial expressions from 0 to 100% emotional in 21 steps every 0.2 s). Although recognition of surprise, fear and anger was significantly reduced in the patient group compared with the healthy controls, the significance of the difference disappeared after 3 months of treatment with quetiapine [67]. Radua et al [1] reported that fMRI revealed reduced activity, especially in the amygdala and hippocampus, in blood oxygenation level-dependent responses of patients to morphed fearful faces compared with healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

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Response of Schizophrenic Patients to Dynamic Facial Expressions: An Event-Related Potentials Study

Fukuta

Kirino²,

Inoue³

et al. 2014

Neuropsychobiology

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Objective: Patients with schizophrenia have an impaired ability to respond to faces and may specifically show an impaired response to dynamic facial expressions. Here we investigated the responses of schizophrenic patients and healthy controls to dynamic facial images using event-related potentials (ERPs). Methods: We showed 13 schizophrenic patients and 13 healthy controls visual stimuli comprising facial expressions that continually changed from neutral to emotional. Results: N200 latencies and P100-N200 peak-to-peak amplitudes in controls were prolonged or greater for dynamic emotions in comparison with those for static stimuli, but the group with schizophrenia showed no significant differences in responses to dynamic and static emotions. A significant negative correlation was observed between N200 latencies for dynamic negative emotion and PANSS (positive and negative syndrome scale) general psychopathology scale scores. Conclusions: A combination of hypersensitivity to static emotions and hyposensitivity to dynamic emotions in people with schizophrenia might underlie the absence of differences in response to these stimuli. A tendency in the schizophrenic group to hypersensitivity to static emotions might arise from the enhanced fear and arousal characteristics of this group; their hyposensitivity to dynamic emotions might result from controlled attentional bias away from facial expressions to reduce fear and anxiety.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Response of Schizophrenic Patients to Dynamic Facial Expressions: An Event-Related Potentials Study

Fukuta

Kirino²,

Inoue³

et al. 2014

Neuropsychobiology

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“…Changing the estimate of the correlation coefficient when summing SDs across subscale data from Cabral-Calderin et al (2010) had no effect on the overall pooled effect size.…”

Section: Resultsmentioning

confidence: 96%

“…Overall there was no bias with regard to which emotions were examined. Two studies (Daros et al, 2014; Harvey et al, 2006) only focused on two emotions – the range of intensity from very happy to very sad; four studies (Behere et al, 2009; Cabral-Calderin et al, 2010; Lewis and Garver, 1995; Wölwer et al, 1996) investigated processing of happiness, disgust, sadness, surprise, anger and fearful expressions; one study (Bediou et al, 2007) investigated processing of neutral, happiness, disgust, fear and anger; two studies investigated processing of happiness, sadness, anger, surprise, fear and shame (Penn et al, 2009; Sergi et al, 2007). …”

Section: Resultsmentioning

confidence: 99%

Facial affect processing deficits in schizophrenia: A meta-analysis of antipsychotic treatment effects

2014

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Social cognition, including emotion processing, is a recognised deficit observed in patients with schizophrenia. It is one cognitive domain which has been emphasised as requiring further investigation, with the efficacy of antipsychotic treatment on this deficit remaining unclear. Nine studies met our criteria for entry into a meta-analysis of the effects of medication on facial affect processing, including data from 1162 patients and six antipsychotics. Overall we found a small, positive effect (Hedge’s g = 0.13, 95% CI 0.05 to 0.21, p = 0.002). In a subgroup analysis this was statistically significant for atypical, but not typical, antipsychotics. It should be noted that the pooled sample size of the typical subgroup was significantly lower than the atypical. Meta-regression analyses revealed that age, gender and changes in symptom severity were not moderating factors. For the small, positive effect on facial affect processing, the clinical significance is questionable in terms of treating deficits in emotion identification in schizophrenia. We show that antipsychotic medications are poor at improving facial affect processing compared to reducing symptoms. This highlights the need for further investigation into the neuropharmacological mechanisms associated with accurate emotion processing, to inform treatment options for these deficits in schizophrenia.

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“…Few studies were of a longitudinal study design, and so it is unclear whether these tests are useful for monitoring progress and outcomes ( Cabral-Calderin et al, 2010 ; Guo et al, 2011 ; Nakasujja et al, 2012a ; Heeramun-Aubeeluck et al, 2015 ; Zhou et al, 2017 ; Sagar et al, 2018 ). Also, only one study assessed for quality of life as an outcome ( Alptekin et al, 2005 ) highlighting the strong associations between cognitive impairment and quality of life.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of research on neuropsychological measures in psychotic disorders from low and middle-income countries: The question of clinical utility

Mwesiga

Akena

Koen

et al. 2020

Schizophrenia Research: Cognition

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Introduction Several studies of neuropsychological measures have been undertaken in patients with psychotic disorders from low- and middle-income countries (LMICs). It is, however, unclear if the measures used in these studies are appropriate for cognitive screening in clinical settings. We undertook a systematic review to determine if measures investigated in research on psychotic disorders in LMICs meet the clinical utility criteria proposed by The Working Group on Screening and Assessment. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses were employed. We determined if tests had been validated against a comprehensive test battery, the duration and scope of the tests, the personnel administering the tests, and the means of administration. Results A total of 31 articles were included in the review, of which 11 were from Africa. The studies included 3254 participants with psychosis and 1331 controls. 3 studies reported on the validation of the test against a comprehensive cognitive battery. Assessments took 1 h or less to administer in 6/31 studies. The average number of cognitive domains assessed was four. Nonspecialized staff were used in only 3/31 studies, and most studies used pen and paper tests (17/31). Conclusion Neuropsychological measures used in research on psychotic disorders in LMICs typically do not meet the Working Group on Screening and Assessment clinical utility criteria for cognitive screening. Measures that have been validated in high-income countries but not in LMICs that do meet these criteria, such as the Brief Assessment of Cognition in Schizophrenia, therefore deserve further study in LMIC settings.

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Effect of quetiapine treatment on facial emotion recognition deficits in schizophrenia patients

Cited by 6 publications

References 10 publications

Response of Schizophrenic Patients to Dynamic Facial Expressions: An Event-Related Potentials Study

Response of Schizophrenic Patients to Dynamic Facial Expressions: An Event-Related Potentials Study

Facial affect processing deficits in schizophrenia: A meta-analysis of antipsychotic treatment effects

A systematic review of research on neuropsychological measures in psychotic disorders from low and middle-income countries: The question of clinical utility

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