Effect of Radial Extracorporeal Shock Wave Combined With Ultrashort Wave Diathermy on Fibrosis and Contracture of Muscle

Huang, Pengpeng; Zhang, Quan-Bing; Zhou, Yun; Liu, A-Ying; Wang, Feng; Xu, Qi-Yu; Yang, Fan

doi:10.1097/phm.0000000000001599

Cited by 23 publications

(29 citation statements)

References 25 publications

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“…Among several other roles, one of the adaptive responses of hypoxic cells is the upregulation of hypoxia-inducible factor 1 alpha (HIF-1α). The expressions of TGF-β1 and HIF-1α are signi cantly upregulated during the transformation of broblasts to myo broblasts [35], leading to the promotion of vascular endothelial growth factor (VEGF) gene expression. The HIF-1α signaling pathway in turn regulates angiogenesis by inducing VEGF expression, thereby improving circulation and reducing the in ammatory response [36].…”

Section: Discussionmentioning

confidence: 99%

A Novel External Immobilization Method to Establish a Rat Model of Knee Extension Contracture

Zhou

Wang

et al. 2022

Preprint

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Background: The study aimed to elucidate the formation process and therapeutic strategies of knee extension contracture, we developed a novel rat model using an aluminum external fixator.Methods: Sixty male SD rats with mature bones were divided into the control group (n=6) and groups that had the left knee immobilized with an aluminum external fixator for 1, 2, and 3 days, and 1, 2, 3, 4, 6, and 8 weeks (n=6 in each group). The passive extension range of motion, histology, and expression of fibrosis-related proteins were compared between the control group and the immobilization groups.Results: Myogenic contracture progressed very quickly during the initial 2 weeks of immobilization; after 2 weeks, the contracture gradually changed from myogenic to arthrogenic. The arthrogenic contracture progressed slowly during the first week, rapidly progressed until the third week, and then showed a steady progression. Histological analysis confirmed that the anterior joint capsule of the extended fixed knee became increasingly thicker over time. Correspondingly, the level of TGFβ-1 in the anterior joint capsule also increased with the immobilization time. Over time, the cross-sectional area of muscle fibers gradually decreased, while the amount of intermuscular collagen and TGFβ-1 increased. Unexpectedly, the amount of intermuscular collagen and TGFβ-1 decreased during the late stage of immobilization (6–8 weeks).Conclusion: Myogenic contracture is stabilized after 2 weeks of immobilization, while arthrogenic contracture is stabilized after 3 weeks of immobilization. This novel rat model may be a useful tool to study the etiology of joint contracture and establish new therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

A Novel External Immobilization Method to Establish a Rat Model of Knee Extension Contracture

Zhou

Wang

et al. 2022

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“…Although ultrashort wave diathermy is effective in the treatment of myogenic contracture by inhibiting muscle atrophy, it does not have any beneficial effect on arthrogenic contracture. 5 Muscle atrophy is the result of a change in the balance between protein synthesis and degradation. When the protein degradation is greater than protein synthesis, the mass of muscle tissue decreases.…”

Section: Discussionmentioning

confidence: 99%

Preventive effect and possible mechanisms of ultrashort wave diathermy on myogenic contracture in a rabbit model

Zhang

Zhou

et al. 2021

Science Progress

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The purpose of this study was to determine the preventive effect of ultrashort wave diathermy on immobilization-induced myogenic contracture and to explore its underlying mechanisms. Forty-two rabbits were randomly assigned into control (Group C), immobilization (Group I, which was further divided into one week, Group I-1; two weeks, Group I-2; and four weeks, Group I-4, subgroups by the length of immobilization) and ultrashort wave prevention (Group U, which was further divided into one week, Group U-1; two weeks, Group U-2; and four weeks, Group U-4, by time of treatment) groups. Intervention effects were assessed by evaluating rectus femoris cross-sectional area (CSA), knee range of motion, and the protein levels for myogenic differentiation (MyoD) and muscle atrophy F-box (MAFbx-1) in the rectus femoris. Compared with those of Group C, in Groups I and U, total contracture, myogenic contracture, MyoD and MAFbx-1 levels were significantly elevated, and CSA was significantly smaller ( p < 0.05). Compared with those of Group I at each time point, MyoD levels were significantly elevated, MAFbx-1 levels were significantly lower, CSA was significantly larger, and myogenic contracture was significantly alleviated in Group U ( p < 0.05). In the early stages of contracture, ultrashort wave diathermy reduces muscle atrophy and delays the process of myogenic contracture during joint immobilization; the mechanism of this may be explained as increased expression of MyoD triggered by suppression of the MAFbx-1-mediated ubiquitin-proteasome pathway.

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“…Knee joint injuries usually require xation in an extended or functional position to promote tissue healing. Therefore, the extension position or functional position xation is a common orthopedic treatment for knee trauma or other musculoskeletal diseases [25]. To be consistent with clinical practice, we used tubular plaster external xation to establish a rabbit knee joint extension contracture model [20].…”

Section: Discussionmentioning

confidence: 99%

Low-frequency Electrical Stimulation Alleviates Immobilization-evoked Disuse Muscle Atrophy via Repressing Autophagy in Skeletal Muscle of Rabbits

Liu¹,

Zhang²,

Zhu³

et al. 2021

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Objective: The present study was to investigate the effect of low-frequency electrical stimulation on disuse muscle atrophy and its mechanism in a rabbit model of extending knee joint contracture.Methods: This study designed two experiments. In the time-point experiment, 24 rabbits were randomly divided into Control 1(Ctrl1), immobilization for 2 weeks (I-2), I-4, and I-6 groups. In the intervention experiment, 24 rabbits were also randomly divided into Control 2 (Ctrl2), electrical stimulation (ES), natural recovery (NR) and electrical stimulation treatment (EST) groups. All intervention effects were assessed by evaluating the knee joint range of motion (ROM), cross-sectional area (CSA) of muscle and the expression of autophagy-related proteins.Results: Time-point experiment showed that immobilization reduced knee ROM, muscle CSA, and activated autophagy in skeletal muscle. Levels of four autophagic proteins including p-mTOR, Atg7, p62 and LC3B-II, were significantly elevated in the skeletal muscle of I-4 group. The intervention experiment further presented that LFES significantly improved the immobilization-induced ROM and CSA reduction. Additionally, LFES significantly reversed autophagy activation of skeletal muscle caused by immobilization.Conclusions: Low-frequency electrical stimulation alleviates immobilization-evoked disuse muscle atrophy maybe via inhibiting autophagy in skeletal muscle of rabbits.

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Effect of Radial Extracorporeal Shock Wave Combined With Ultrashort Wave Diathermy on Fibrosis and Contracture of Muscle

Cited by 23 publications

References 25 publications

A Novel External Immobilization Method to Establish a Rat Model of Knee Extension Contracture

A Novel External Immobilization Method to Establish a Rat Model of Knee Extension Contracture

Preventive effect and possible mechanisms of ultrashort wave diathermy on myogenic contracture in a rabbit model

Low-frequency Electrical Stimulation Alleviates Immobilization-evoked Disuse Muscle Atrophy via Repressing Autophagy in Skeletal Muscle of Rabbits

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