2022
DOI: 10.1111/jvim.16560
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Effect of radioiodine treatment on muscle mass in hyperthyroid cats

Abstract: Background Approximately 75% of hyperthyroid cats lose muscle mass as accessed with a muscle condition scoring (MCS) system. After treatment, MCS improves as the cats regain muscle mass. Objectives To quantify the degree of muscle loss in hyperthyroid cats using ultrasonography and evaluate changes in muscle mass after treatment. Animals Forty‐eight clinically normal cats and 120 cats with untreated hyperthyroidism, 75 of which were reevaluated after radioiodine‐131 therapy. Methods Prospective cross‐sectional… Show more

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Cited by 4 publications
(4 citation statements)
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“…Although the goal of 131 I treatment is to cure hyperthyroidism and restore euthyroidism, most current dosing protocols fail to achieve this goal, with 20% to 50% of 131 I‐treated cats developing iatrogenic hypothyroidism after treatment 9,32,36,38,58,59 . Determination of thyroid status is of vital importance when assessing these 131 I‐treated cats for CKD, because cats with iatrogenic hypothyroidism have a higher prevalence of azotemia than euthyroid cats, 2,14,25,32,36 as did the hypothyroid cats in this study (2.2‐fold higher than our euthyroid cats; Figure 4B; Table S5). The azotemia that develops in cats with iatrogenic hypothyroidism, however, can sometimes be improved or even reversed with levothyroxine supplementation 25,60 .…”
Section: Discussionmentioning
confidence: 74%
See 1 more Smart Citation
“…Although the goal of 131 I treatment is to cure hyperthyroidism and restore euthyroidism, most current dosing protocols fail to achieve this goal, with 20% to 50% of 131 I‐treated cats developing iatrogenic hypothyroidism after treatment 9,32,36,38,58,59 . Determination of thyroid status is of vital importance when assessing these 131 I‐treated cats for CKD, because cats with iatrogenic hypothyroidism have a higher prevalence of azotemia than euthyroid cats, 2,14,25,32,36 as did the hypothyroid cats in this study (2.2‐fold higher than our euthyroid cats; Figure 4B; Table S5). The azotemia that develops in cats with iatrogenic hypothyroidism, however, can sometimes be improved or even reversed with levothyroxine supplementation 25,60 .…”
Section: Discussionmentioning
confidence: 74%
“…[1][2][3] This is of clinical importance, since hyperthyroidism is a reported risk factor for chronic kidney disease (CKD), [4][5][6] in which a USG <1.035 is expected. 7,8 Furthermore, hyperthyroidism can complicate (mask) the diagnosis of azotemic CKD by increasing renal blood flow and glomerular filtration rate (GFR) [9][10][11][12] and decreasing body muscle mass, 13,14 thereby lowering serum creatinine concentration to within its reference interval. Consequently, many hyperthyroid cats with concurrent CKD only develop azotemia after successful treatment, when hyperthyroidism no longer maintains high renal blood flow and GFR.…”
Section: Introductionmentioning
confidence: 99%
“…Decreased creatine phosphate in hyperthyroid cats and increased creatine in hyperthyroid humans may reflect species differences or could imply altered conversion. Lower creatine phosphate (phosphocreatine) may reflect lower muscle masses often seen in hyperthyroid cats [ 11 , 12 ]. As creatine phosphate serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium, and the brain, reduced serum levels also reflect changes in energy metabolism at these sites [ 13 , 14 ].…”
Section: Resultsmentioning
confidence: 99%
“…Lower creatine phosphate (phosphocreatine) may re ect lower muscle masses often seen in hyperthyroid cats. 34,35 As creatine phosphate serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium, and the brain, reduced serum levels also re ect changes in energy metabolism at these sites. 36,37 In this study, post-I-131 treatment creatine phosphate levels improved but were still signi cantly reduced compared to controls, further indicating persistent negative energy balance in previously hyperthyroid cats.…”
Section: Discussionmentioning
confidence: 99%