Effect of radiotherapy on anorectal function in patients with cervical cancer

Iwamoto, Takuya; Nakahara, Shosaku; Mibu, Ryuichi; Hotokezaka, Masayuki; Nakano, Hitoo; Tanaka, Masao

doi:10.1007/bf02140899

Cited by 50 publications

(29 citation statements)

References 15 publications

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“…In the present study, RT and CT/RT were associated with high rates of diarrhea and frequent evacuations. These results are corroborated by others who have also documented the side effects of pelvic radiation on defecation (20,21). This is relevant because some data suggest that acute toxicity and diarrhea during radiation therapy of cervical carcinoma significantly increased the risk of severe late toxicity, therefore, affecting patient's quality of life (22).…”

Section: Discussionsupporting

confidence: 75%

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

et al. 2013

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Aims: Describe the impact of surgery, radiotherapy and chemoradiation in the pelvic floor functions in cervical cancer patients. Materials and Methods: A prospective study with women submitted to radical hysterectomy (RH) (n = 20), exclusive radiotherapy (RT) (n = 20) or chemoradiation (CT/RT) (n = 20) for invasive cervical cancer. Urinary, intestinal and sexual function, as well as vaginal length and pelvic floor muscle contraction were evaluated. Comparisons between groups were performed by Kruskal-Wallis and Chi-square tests (p < 0.05). Results: The groups were similar in stress urinary incontinence incidence (p = 0.56), urinary urgency (p = 0.44), urge incontinence (p = 0.54), nocturia (p = 0.53), incomplete bowel emptying (p = 0.76), bowel urgency (p = 0.12) and soilage (p = 0.43). The CT/ RT group presented a higher urinary frequency (p < 0.001) and diarrhea (p = 0.025). Patients in the RH group were more sexually active (p = 0.01) and experienced less dyspareunia (p = 0.021). Vaginal length was shorter in RT group (5.5 ± 1.9 cm) and CT/ RT(5.3 ± 1.5 cm) than in the RH group (7.4 ± 1.1 cm) (p < 0.001). Pelvic floor muscle contraction was similar (p = 0.302). Conclusions: RT and CT/RT treatment for cervical carcinoma are more associated to sexual and intestinal dysfunctions.

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Section: Discussionsupporting

confidence: 75%

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

et al. 2013

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“…Some studies reported a decreased MSP four to six weeks after radiotherapy, 23,24 while others have found no difference at all. 12,28,29 This is confounded by variations in pathology, total radiation dose, and the way in which the radiation is delivered between studies. Kim et al 24 studied the effect of radiotherapy in patients with cervical cancer and found a significantly reduced MSP when compared with agematched female volunteers.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Chemoradiation for Rectal Cancer Causes Prolonged Pudendal Nerve Terminal Motor Latency

Lim

Tjandra

Hiscock

et al. 2006

Diseases of the Colon &Amp; Rectum

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“…Tissue biopsy may be inconclusive. The few small longitudinal studies of ano-rectal physiological parameters following RT that have been published are contradictory (Iwamoto et al, 1997;Yeoh et al, 2000).…”

mentioning

confidence: 99%

Systematic review for non-surgical interventions for the management of late radiation proctitis

et al. 2002

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Chronic radiation proctitis produces a range of clinical symptoms for which there is currently no recommended standard management. The aim of this review was to identify the various non-surgical treatment options for the management of late chronic radiation proctitis and evaluate the evidence for their efficacy. Synonyms for radiation therapy and for the spectrum of lower gastrointestinal radiation toxicity were combined in an extensive search strategy and applied to a range of databases. The included studies were those that involved interventions for the non-surgical management of late radiation proctitis. Sixtythree studies were identified that met the inclusion criteria, including six randomised controlled trials that described the effects of anti-inflammatory agents in combination, rectal steroids alone, rectal sucralfate, short chain fatty acid enemas and different types of thermal therapy. However, these studies could not be compared. If the management of late radiation proctitis is to become evidence based, then, in view of its episodic and variable nature, placebo controlled studies need to be conducted to clarify which therapeutic options should be recommended. From the current data, although certain interventions look promising and may be effective, one small or modest sized study, even if well-conducted, is insufficient to implement changes in practice. In order to increase recruitment to trials, a national register of cases with established late radiation toxicity would facilitate multi-centre trials with specific entry criteria, formal baseline and therapeutic assessments providing standardised outcome data.

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Effect of radiotherapy on anorectal function in patients with cervical cancer

Abstract: Radiation reduces the capacity of the rectal reservoir, even in asymptomatic patients. These changes develop during radiotherapy and progress over time.

Cited by 50 publications

References 15 publications

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

Preoperative Chemoradiation for Rectal Cancer Causes Prolonged Pudendal Nerve Terminal Motor Latency

Systematic review for non-surgical interventions for the management of late radiation proctitis

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