Effect of radium treatment on the enzyme content of vaginal fluid in cervical cancer

Goldberg, David M.; Watts, Colin; Hart, D. M.

doi:10.1016/0002-9378(69)90288-9

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1972

1979

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“…Much evidence implicates damage to cell membranes as a causative factor. In addition to loss of nicotinamide, activation of enzymes by disruption of lysosomes appears to take place in irradiated cervical cancer tissue (Goldberg et al, 1967) and in exfoliated cancer cells obtained by vaginal irrigation (Goldberg et al, 1969;Goldberg, 1971). Leakage of pyruvate (Dose & Dose, 1962) and of K+ (Flemming et al, 1968) also indicate altered permeability of the cell, which must have profound consequences for its metabolic integrity.…”

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confidence: 99%