Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang, Zhenwei; Yang, Wenlan; Yang, Ping; Gao, Beilan; Luo, Lei

doi:10.1186/s12906-016-1444-y

Cited by 10 publications

(9 citation statements)

References 32 publications

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“…In addition, the detection of inflammatory indicators in the lung showed that the levels of TNF-, IL-6, IL-8 and IL-10 from BALF in the PRVC group were significantly lower than those in the VC group, suggesting that excessive airway pressure may lead to the structural destruction of lung tissue with poor compliance, thus causing airway injury. This result is consistent with the results of related literatures [17][18][19][20] .…”

Section: Discussionsupporting

confidence: 94%

The application of Pressure-regulated volume controlled ventilation mode in Video-assisted Thoracoscopic Surgery pulmonary segmentectomy

Han

Yao

Zhang

et al. 2019

Preprint

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Background: Pressure-regulated capacity control volume controlled (PRVC) ventilation mode is a new type of ventilation mode, which could reduce the occurrence of ventilator-related lung injury. The aim of this study was to explore PRVC mode on airway pressure, oxygenation index, pulmonary inflammatory index and prognosis in patients with one-lung ventilation during pulmonary segmentectomy.Methods: Eighty ASA Ⅱ-Ⅲ Patients with moderate to severe pulmonary dysfunction, ready to receive segmentectomy were randomly divided into VC and PRVC group, which included 40 patients in each group. PRVC ventilation mode was performed for patients in VC-group in the first 5 minutes after OLV, and then ventilation mode was transformed into VC ventilation mode till the end of operation. In PRVC-group, ventilation modes were performed in opposite order. The changes of airway peak pressure, airway platform pressure, pulmonary static compliance, blood gas analysis results and hemodynamics in the two groups under different ventilation modes were recorded. The whole blood samples and bronchoalveolar lavage fluid (BALF) in ventilated lung were collected to determine the level of TNF-α, IL-1β, IL-6 and IL-8 after the surgery. Results: Both static lung compliance and the peak expiratory pressure in PRVC-group were significantly lower than those in VC-group (P=0.023). But there were no difference in hemodynamic parameters such as heart rate, blood pressure. The arterial blood gas analysis (pH, pO2 and pCO2) between the two groups during, as well as postoperative pulmonary complications and length of hospital stay also did not show difference. However, the levels of TNF-α, IL-6, IL-8 and IL-10 in BALF in VC-group were significantly higher than that in PRVC-group (P=0.01). Conclusion: PRVC ventilation mode during intraoperative one-lung ventilation can effectively relieve airway pressure and reduce the secretion of inflammatory factors in the lung, which is a safe and protective ventilation mode for patients with poor preoperative pulmonary function who undergo pulmonary segmentectomy.

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Section: Discussionsupporting

confidence: 94%

The application of Pressure-regulated volume controlled ventilation mode in Video-assisted Thoracoscopic Surgery pulmonary segmentectomy

Han

Yao

Zhang

et al. 2019

Preprint

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“…Radix Stemonae, also known as Baibu, is one of the most popular herbal medicines used in many Asian countries, including China, Korea, Japan, Thailand and Vietnam. It has been used for the treatment of various respiratory diseases such as bronchitis, pertussis and tuberculosis [1,2]. It was also used for killing cattle parasites, agricultural pests and domestic insects [3,4].…”

Section: Introductionmentioning

confidence: 99%

Comparative genome analysis revealed gene inversions, boundary expansions and contractions, and gene loss in the Stemona sessilifolia (Miq.) Miq. chloroplast genome

et al. 2021

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Stemona sessilifolia (Miq.) Miq., commonly known as Baibu, is one of the most popular herbal medicines in Asia. In the Chinese Pharmacopoeia, Baibu has multiple authentic sources and there are many similar herbs sold as Baibu in herbal medicine markets. The existence of counterfeits of Baibu brings challenges to its identification. To assist in its accurate identification, we sequenced and analyzed the complete chloroplast genome of S. sessilifolia using next-generation sequencing technology. The genome was found to be 154,037 bp in length, possessing a typical quadripartite structure consisting of a pair of inverted repeats (IRs: 27,090 bp) separated by a large single copy (LSC: 81,949 bp) and a small single copy (SSC: 17,908 bp). A total of 112 unique genes were identified, including 80 protein-coding, 28 transfer RNA and four ribosomal RNA genes. In addition, 45 tandem, 27 forward, 23 palindromic and 104 simple sequence repeats were detected in the genome by repeated analysis. Compared with its counterfeits (Asparagus officinalis and Carludovica palmata) we found that IR expansion and SSC contraction events of S. sessilifolia resulted in two copies of the rpl22 gene in the IR regions and a partial duplication of the ndhF gene in the SSC region. An approximately 3-kb-long inversion was also identified in the LSC region, leading to the petA and cemA genes being presented in the complementary strand of the chloroplast DNA molecule. Comparative analysis revealed some highly variable regions, including trnF-GAA_ndhJ, atpB_rbcL, rps15_ycf1, trnG-UCC_trnR-UCU, ndhF_rpl32, accD_psaI, rps2_rpoC2, trnS-GCU_trnG-UCC, trnT-UGU_trnL-UAA and rps16_trnQ-UUG. Finally, gene loss events were investigated in the context of phylogenetic relationships. In summary, the complete plastome of S. sessilifolia will provide valuable information for the distinction between Baibu and its counterfeits and assist in elucidating the evolution of S. sessilifolia.

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“…The present study supports that TLRs (TLR4, TLR2) decrease and phosphorylated (active) IκB (p-IκB) and NF-κB p65 increase in COPD model rats, and further increase pro-inflammatory cytokines, while Feikang granules protect these inflammatory responses. However, whether the Feikang granules also trigger the upstream of anti-inflammatory signaling pathways, such as TGF-β, need to be further investigated [18,25].…”

Section: Discussionmentioning

confidence: 99%

“…A few studies of Feikang Granules on animals have a specific protective effect on vascular endothelial injury in hypoxic pulmonary hypertension [17] and significantly reduce the Transforming Growth Factor β 1 in COPD model Rats [16]. It has been showed that Chinese medicine Radix Stemonae significantly decreases the concentrations of inflammatory mediators TNF-α, IL-8 and LTB4 of COPD model rats [18]. Whether Feikang Granules alleviate the clinical symptoms in COPD patients also involved in the anti-inflammation mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Feikang granules ameliorate pulmonary inflammation in the rat model of chronic obstructive pulmonary disease via TLR2/4-mediated NF-κB pathway

Yang

Wen

Liu

et al. 2020

BMC Complement Med Ther

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Purpose: Several reports have shown that traditional Chinese medicine could be an alternative therapeutic approach for COPD patients, but the mechanism remains unknown. The present study aimed to examine the effects of Feikang granules in a COPD model rat and investigate the possible mechanisms via Toll-like receptor (TLR)/ nuclear factor kappa B (NF-κB) signaling. Methods: The COPD model rats were treated with Feikang granules, dexamethasone, or normal saline. The pulmonary function; lung tissue histology; levels of inflammatory cytokines; mRNA levels of TNFα, IL-6, TLR4, and TLR2; and protein levels of TLR4, TLR2, p-IκB, IκB and P65 in lung tissues were evaluated. Results: The present study confirmed that the pro-inflammatory cytokines, TNF-α, IL-1β, IL-6, and IL-17 levels were elevated and the pulmonary function and morphology are altered in COPD model rats. The TLR2 and TLR4-mediated NF-kB signaling pathway plays a role in the mechanism of action. Feikang granules, a type of Chinese herbal medicine, significantly reduced LPS induced inflammatory cytokines release from lung tissue and alveolar macrophage in a dosedependent manner. These medical herbs also prevented TLR2/4 and IκB downregulation and reversed the p-IκB and NF-κB p65 upregulation of the lung tissue in the COPD rats. Feikang granules were also found to protect against pulmonary dysfunction and pathological changes in the COPD rats. Conclusion: The Chinese herbal medicine formula Feikang granules prevent pulmonary inflammation and improve pulmonary function, suggesting that Feikang granules may be an effective treatment for chronic pulmonary diseases, such as COPD.

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Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Cited by 10 publications

References 32 publications

The application of Pressure-regulated volume controlled ventilation mode in Video-assisted Thoracoscopic Surgery pulmonary segmentectomy

The application of Pressure-regulated volume controlled ventilation mode in Video-assisted Thoracoscopic Surgery pulmonary segmentectomy

Comparative genome analysis revealed gene inversions, boundary expansions and contractions, and gene loss in the Stemona sessilifolia (Miq.) Miq. chloroplast genome

Feikang granules ameliorate pulmonary inflammation in the rat model of chronic obstructive pulmonary disease via TLR2/4-mediated NF-κB pathway

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