Effect of Ramadan fasting on platelet aggregation in healthy male subjects

Aybak, Mehmet; Türkoğlu, Abdülbaki; Şermet, Abdurrahman; Denli, Orhan

doi:10.1007/bf00357678

Cited by 37 publications

(20 citation statements)

References 19 publications

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“…Platelet count remained constant but platelet response to aggregating agents such as ADP, collagen and adrenaline dropped towards the end of Ramadan. 31 In conclusion, Ramadan fasting is a healthy method for improving the CHD risk profile. Since many factors can influence the effects of Ramadan fasting on biochemical and physiologic parameters (such as diet, daily activity, sleep pattern, the season of fasting, socio-economic factors,geography and climate), we recommend large-scale coordinated multi-centre studies, with standardized methodology, to explore the issue more extensively.…”

Section: Discussionmentioning

confidence: 95%

Effect of Ramadan Fasting on Clinical and Biochemical Parameters in Healthy Adults

et al. 2003

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Coronary heart disease (CHD) is primarily a disease of occidental culture, being more prevalent in populations that have adopted a high-fat, high-cholesterol diet, who smoke and do not engage in sufficient physical activity. 1 The Islamic religion prescribes fasting during Ramadan for all healthy Muslims for ostensibly moral and spiritual reasons. It may, however, be viewed as an effective model for CHD risk profile modulation.The effect of Ramadan fasting on cardiovascular risk factors is still a matter of debate. Energy intake decreases during Ramadan, 2-5 as do weight 2-5 and body fat percentage. 3,5 The effect of Ramadan fasting on serum lipid profile is not so clear, however. Numerous studies report improvements in serum lipoproteins, while a few report a deterioration in the LDL:HDL cholesterol ratio during Ramadan. 4 There seems to be a reduction in the number of hospitalizations for acute coronary events during the month of Ramadan, 6 although this cannot be entirely or necessarily attributed to the physical restrictions, which the faithful endure during this month.This study was performed to evaluate alterations in CHD risk profile during the holy month of Ramadan. Materials and MethodsNinety-one healthy volunteers aged 20.8±3.1 years from two seminary schools in Rey, south of Tehran, took part in this study during Ramadan 2000 (1442 in the lunar calendar). The sample consisted of 50 men (age 19.9±1.8 years) and 41 women (age 21.9±3.9 years). All participants had the same diet and level of physical activity. Participants fasted from sunrise to sunset for at least 25 days during Ramadan. Dietary intake was recorded using a semi-quantitative food frequency questionnaire on days zero and 14 of fasting. None of the students smoked or was taking any medication at the time of the study.Blood samples were collected twice: first, one week before Ramadan after a 12-hour overnight fast (baseline) and then on the 28 th day of Ramadan, just before sunset. Anthropometric measures were performed at the same time as blood sampling.Biochemical measurements took place at the laboratory of the Endocrine and Metabolism Research Centre, affiliated to the Tehran University of Medical Sciences.Blood samples were centrifuged and the supernatant plasma stored at -25°C. All blood samples were analyzed in a single batch to avoid day-to-day laboratory variation. Glucose, total cholesterol (T-C) and triglyceride (TG) levels were measured by auto-analyser (Hitachi 911, Böhringer Mannheim, Germany) with standard reagents supplied by the company. High-density lipoprotein cholesterol (HDL-C) was measured enzymatically from the supernatant obtained after precipitation of apolipoprotein B-containing lipoproteins (very low-density lipoprotein [VLDL] and LDL) by dextran sulphate and Mg ++ (HDL-Cholesterol kit, Sigma Diagnostics, USA). The intra-assay and inter-assay variation coefficients were less than 1%. Low-density lipoprotein (LDL-C) levels were then calculated using the Friedwald formula (all participants had TG values <400 mg/dl)....

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Section: Discussionmentioning

confidence: 95%

Effect of Ramadan Fasting on Clinical and Biochemical Parameters in Healthy Adults

et al. 2003

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“…These increases may be relevant to CHD as previous prospective studies suggest that CHD risk is approximately 70% greater in those having higher plasma D -dimer levels [5,16,17] . Aybak et al [18] showed that Ramadan fasting led to a decrease in the platelet responses to different aggregating agents. On the other hand, an increase in bleeding and coagulation time (but not above the physiologic limits) had been shown by the same study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intermittent Fasting on Serum Lipid Levels, Coagulation Status and Plasma Homocysteine Levels

Aksungar¹,

Eren

Ure

et al. 2005

Ann Nutr Metab

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Background: During Ramadan, Muslims fast during the daylight hours for a month. The duration of restricted food and beverage intake is approximately 12 h/day which makes Ramadan a unique model of intermittent fasting. Many physiological and psychological changes are observed during Ramadan that are probably due to the changes in eating and sleeping patterns. Methods: Serum total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), prothrombin time, activated partial thromboplastin time (aPTT), plasma fibrinogen, D-dimer and homocysteine levels were measured in 24 healthy fasting volunteers (12 females, 12 males) aged 21–35 years. Venous blood samples were taken 1 week before Ramadan, on the 21st day of Ramadan and 20 days after Ramadan. Results: No significant changes were observed on serum total cholesterol, triglycerides and LDL levels. HDL levels were significantly elevated during Ramadan (p < 0.001) and 20 days after Ramadan (p < 0.05). Prothrombin time, aPTT, fibrinogen and D-dimer levels were in the physiologic limits in all samples but D-dimer levels were significantly low at the end of Ramadan in comparison to pre- and post-fasting levels (p < 0.001). Homocysteine levels, being still in reference ranges, were low during Ramadan (p < 0.05) and reached the pre-fasting levels after Ramadan. Conclusion: Our results demonstrate that intermittent fasting led to some beneficial changes in serum HDL and plasma homocysteine levels, and the coagulation status. These changes may be due to omitting at least one meal when the body was particularly metabolically active and possibly had a low blood viscosity level at the same time. We conclude that intermittent fasting may have beneficial effects on hemostatic risk markers for cardiovascular diseases.

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“…When the circadian variation of glucose blood levels was determined with the blood sampling done every 2 h (except in the time of sleep which was from 2: 00 to 8: 00 h), the results showed that this parameter increased at 2: 30 and 8: 00 h and decreased at 17: 30 h. The 24-hour mean decreased during Ramadan in comparison to the control day before the fasting [27] . Another study, where the blood samples were taken at 16: 00 h both before and during Ramadan, confi rmed the decrease in the afternoon blood glucose [28] .…”

Section: Meals and Energy Intake And Body Weight During Ramadanmentioning

confidence: 99%

“…Moreover, the platelet count [50] and responses to different aggregation agents decreased, leading to an increase in bleeding and coagulation time [28,55,56] . Antithrombin III also decreased in the morning and in the afternoon [56] .…”

Section: Hematological Changesmentioning

confidence: 99%

“…Concerning serum protein levels, an increase was demonstrated for total proteins [16,28,29,42] , albumin [5,16,29,42,43] , creatinine [5,16,31,[42][43][44] , bilirubin [16] and hematocrit [5] . The most important change observed during Ramadan was the increase of serum uric acid [13,18,24,42,[44][45][46][47] , urea [32,40,48,49] and serum osmolarity [42,50] .…”

Section: Glucose Lipids and Protein Level During Ramadanmentioning

confidence: 99%

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Physiological and Chronobiological Changes during Ramadan Intermittent Fasting

et al. 2004

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Background and Aims: During the month of Ramadan, Moslems refrain from drinking and eating between sunrise and sunset. This review aimed to analyze the effects of Ramadan fasting on physiological and behavioral variables in healthy subjects. Methods: Articles included in this paper were taken from Medline, three international congresses on health and Ramadan, and in several cases from local journals. Results: Ramadan fasting did not dramatically affect the metabolism of lipids, carbohydrates and proteins, or the daily mean of hormonal serum levels. An increase in serum urea and uric acid was frequently reported and this could be attributed to dehydration during this month. Some changes, such as the increase of HDL and apoprotein A1, and the decrease in LDL, could be beneficial for the cardiovascular system. However, the chronobiological studies have shown that Ramadan fasting affects the circadian distribution of body temperature, cortisol, melatonin and glycemia. The amplitude of most of these rhythms decreased and the acrophase shifted. Nocturnal sleep, daytime alertness and psychomotor performance were decreased. Conclusion: The major changes during Ramadan fasting are chronobiological and behavioral. They could be responsible for the high incidence of road traffic accidents and the reduction of working hours during the month of Ramadan.

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Effect of Ramadan fasting on platelet aggregation in healthy male subjects

Cited by 37 publications

References 19 publications

Effect of Ramadan Fasting on Clinical and Biochemical Parameters in Healthy Adults

Effect of Ramadan Fasting on Clinical and Biochemical Parameters in Healthy Adults

Effects of Intermittent Fasting on Serum Lipid Levels, Coagulation Status and Plasma Homocysteine Levels

Physiological and Chronobiological Changes during Ramadan Intermittent Fasting

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