Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depression, and quality of life in patients with inflammatory bowel diseases: A prospective cohort study

Negm, Mohamed; Bahaa, A; Farrag, Ahmed; Lithy, Rania; Badary, Hedy A; Essam, Mahmoud; Kamel, Solaf; Sakr, Mohamed A.; Aaty, Waleed Abd El; Shamkh, Mostafa Abd Alfattah; Basiony, Ahmed El; Dawoud, Ibrahim; Shehab, Hany

doi:10.1186/s12876-022-02272-3

Cited by 18 publications

(21 citation statements)

References 55 publications

(49 reference statements)

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“…However, Negm M et al recruited 80 patients with IBD to observe the effect of Ramadan intermittent fasting on disease activity, which is part of the religious rituals of Muslims. They found that the Mayo score had significantly risen after intermittent fasting, especially in older patients and those with higher baseline calprotectin levels, but serum CRP and stool calprotectin did not change significantly before vs. after fasting [ 176 ]. The therapeutic potential of intermittent fasting on IBD needs more human studies.…”

Section: Dietary Strategies Alleviating Ibdmentioning

confidence: 99%

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Yan

Lei

et al. 2022

Nutrients

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Inflammatory bowel disease (IBD) is a result of a complex interplay between genes, host immune response, gut microbiota, and environmental factors. As one of the crucial environmental factors, diet plays a pivotal role in the modulation of gut microbiota community and the development of IBD. In this review, we present an overview of dietary patterns involved in the pathogenesis and management of IBD, and analyzed the associated gut microbial alterations. A Westernized diet rich in protein, fats and refined carbohydrates tends to cause dysbiosis and promote IBD progression. Some dietary patterns have been found effective in obtaining IBD clinical remission, including Crohn’s Disease Exclusion Diet (CDED), Mediterranean diet (MD), Anti-Inflammatory Diet (AID), the low-“Fermentable Oligo-, Di-, Mono-saccharides and Polyols” (FODMAP) diet, Specific Carbohydrate Diet (SCD), and plant-based diet, etc. Overall, many researchers have reported the role of diet in regulating gut microbiota and the IBD disease course. However, more prospective studies are required to achieve consistent and solid conclusions in the future. This review provides some recommendations for studies exploring novel and potential dietary strategies that prevent IBD.

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Section: Dietary Strategies Alleviating Ibdmentioning

confidence: 99%

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Yan

Lei

et al. 2022

Nutrients

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“…in older patients and these may have contributed to changes in the physician's assessment portion of the PMS. 9 Reasons for why these results differ somewhat from those in the studies of rheumatic diseases 12,13 are speculative in the absence of other published literature but could be related to effects on the gut microbiome, autophagy, and other similar pathophysiologic mechanisms that underpin IBD and other immune-mediated diseases.…”

Section: Therapeutic Advances In Gastroenterologymentioning

confidence: 84%

A review of the role of intermittent fasting in the management of inflammatory bowel disease

Lavallee

Bruno

et al. 2023

Therap Adv Gastroenterol

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Intermittent fasting (IF) may be a weight management strategy for patients with inflammatory bowel disease (IBD). The aim of this short narrative review is to summarize the evidence related to IF in the management of IBD. A literature search of English publications related to IF or time-restricted feeding and IBD, Crohn’s disease, or ulcerative colitis was conducted in PubMed and Google Scholar. Four publications on studies of IF in IBD were found: three randomized controlled trials in animal models of colitis and one prospective observational study in patients with IBD. The results from animal studies suggest either moderate or no changes in weight but improvements in colitis with IF. These improvements may be mediated through changes in the gut microbiome, decreased oxidative stress and increased colonic short-chain fatty acids. The study in humans was small and uncontrolled, and it did not assess changes in weight, making it difficult to draw conclusions around the effects of IF on changes in weight or disease course. Given that preclinical evidence suggests intermittent fasting may play a beneficial role in IBD, randomized controlled trials in large patients with active disease are warranted to determine whether intermittent fasting could be an integrated therapy for patients with IBD management, either for weight or for disease management. These studies should also explore the potential mechanisms of action related to intermittent fasting.

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“…The effects on clinical disease activity, quality of life, and levels of depression were assessed. 55 Patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) intending to observe RF were recruited. The following were assessed immediately before and at the end of Ramadan: serum CRP and stool calprotectin, partial Mayo score, Harvey-Bradshaw index (HBI), Simple IBD questionnaire (SIBDQ), and Hamilton depression scale questionnaire.…”

Section: Gut and Livermentioning

confidence: 99%

Review of the Literature on Ramadan Fasting and Health in 2022

Hafidh

Khan

Shaikh

et al. 2023

Ibnosina Journal of Medicine and Biomedical Sciences

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Objectives The literature on health and disease during Ramadan fasting (RF) is widely spread in many journals making it not readily accessible to those interested in the subject. Here, we provide an overview of the research on the interplay of RF with various aspects of well-being published in 2022. Materials and Methods A narrative, nonsystematic review of the international literature from a single major medical online database, PubMed, in one calendar year (2022) was conducted. The search term “Ramadan fasting” was used to retrieve the appropriate records. The relevant literature with substantial data-based content was presented in a concise thematic account, excluding those concerned with diabetes. Results Themes that emerged from the review included the pathophysiology of metabolic changes during RF, nutritional aspects including body composition and energy metabolism, cardiovascular disease and risk factors, renal function and structure, endocrinology (mainly thyroid), neurological disorders, mental health, pregnancy and fetal life, and infections (including COVID). Some miscellaneous clinical themes were identified, such as patients' and professional perspectives. Conclusions In 2022, the medical interest in RF was again widely spread across specialties. Cardiovascular disease and risk factors attract the most interest in terms of original articles and professional guidelines. We hope with this review to present a concise summary of the scholarly work on the subject in this year.

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Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depression, and quality of life in patients with inflammatory bowel diseases: A prospective cohort study

Cited by 18 publications

References 55 publications

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

A review of the role of intermittent fasting in the management of inflammatory bowel disease

Review of the Literature on Ramadan Fasting and Health in 2022

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