Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats

Triglyceride with Medium-Chain Fatty Acids Increases the Activity and Expression of Hormone-Sensitive Lipase in White Adipose Tissue of C57BL/6J Mice

“…25) The main explanations for the effect of MCT on reducing body fat accumulation are based on some results that MCT increased the energy expenditure in the body and accelerated fatty acid oxidation in the liver or WAT of rats. 12,15) Does MCFA therefore stimulate lipolysis? Lipolysis in the adipose tissue of humans and rodents is regulated in a step-wise pattern by adipose triglyceride lipase (ATGL), HSL, and monoacylglycerol lipase (MAGL).…”

“…Some studies have reported that MCT, compared with LCT, could increase energy expenditure and hepatic fatty acid oxidation in rats and humans. [12][13][14] Some results have also suggested that fatty acid oxidation and synthesis in white adipose tissue (WAT) were different in rats when MCT and LCT had been ingested. 15) It is, however, still unclear how MCT affects the degradation of triglycerides in WAT.…”

Dietary Medium-Chain Triglycerides Attenuate Hepatic Lipid Deposition in Growing Rats with Protein Malnutrition

“…Previous studies in well-nourished rodents have reported that long-term feeding with MCFA attenuates the accumulation of body fat, but induces triglyceride accumulation in the liver (26)(27)(28). The hepatic triglyceride accumulation induced by dietary MCFA was remarkable under sufficient energy intake (26).…”

“…It seems that hepatic triglyceride accumulation was not observed because rats in the CPϩMCT group also existed in a state of energy malnutrition. Furthermore, hepatic triglyceride accumulation induced by dietary MCFA has been shown to be caused by enhancing de novo lipogenesis (27,28). In addition to fatty acid oxidation, it will be important to study the effects of MCT on other pathways that influence hepatic lipid deposition, including lipid uptake and de novo lipogenesis, under conditions of protein malnutrition.…”

Dietary Medium- and Long-chain Triacylglycerols Accelerate Diet-Induced Thermogenesis in Humans

“…That is, the MLCT-accelerated DIT suggests that almost all of the MCFA was consumed. However, Shinohara et al assessed hepatic b-oxidizing system activity after intake of MLCT or MCT in rats, and found that the b-oxidizing system enzyme activity of MLCT was similar or superior to that of MCT 18) . This indicates that not only MCFA taken into the liver may be b-oxidized and metabolized, but also LCFA present in the surrounding area may also be simultaneously consumed.…”