Effect of Rat-to-Mouse Bioartificial Pancreas Xenotransplantation on Diabetic Renal Damage and Survival

Sakata, Naoaki; Gu, Yuanjun; Qi, Meirigeng; Yamamoto, Chidzuru; Hiura, Akihito; Sumi, Shoichiro; Sunamura, Makoto; Matsuno, Seiki; Inoue, Kazutomo

doi:10.1097/01.mpa.0000203959.31877.8c

Cited by 19 publications

(17 citation statements)

References 29 publications

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“…Cryopreservation provides the time for quality control of islets before transplantation [7]. Previous studies described the development of novel sheet-type polyvinyl alcohol (PVA) *Manuscript macro-encapsulated islets (MEIs) by 1-day freezing and succeed in confirming their positive effects on xeno-transplantation [8], allo-transplantation (manuscript in press) and prevention of diabetic nephropathy [9][10].…”

Section: Introductionmentioning

confidence: 99%

The in vivo performance of polyvinyl alcohol macro-encapsulated islets

Shen

Yanai

et al. 2010

Biomaterials

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Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA) macro-encapsulated islets (MEI) to treat type 1 DM without any immunotherapy. The present study examined their beneficial effects on islet cryopreservation. PVA MEI of Wistar rats were divided into three groups of 1-day, 7-day and 30-day cryopreservation at -80 degrees C. The 30-day group showed a lower recovery rate of the islet number and impaired insulin release in comparison to the 1-day group, whereas no significant differences of the in vitro results were observed between the 1-day and 7-day groups. The MEI transplantation recipient mice in the 1-day and 7-day groups reached normoglycemia for a 4-week observation period, and the recipients in 30-day group also showed a significant decrease followed by a slightly higher non-fasting blood glucose level. These results suggest that the PVA MEI are useful for islet long-term cryopreservation, and that the use of cryopreserved PVA MEI may, therefore, be a promising modality for performing DM therapy.

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Section: Introductionmentioning

confidence: 99%

The in vivo performance of polyvinyl alcohol macro-encapsulated islets

Shen

Yanai

et al. 2010

Biomaterials

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“…Qi et al [8] evaluated the function of the sheet type of PVA capsule in vitro and in vivo. Rat islets in the PVA capsule had good function in insulin release and achieved normoglycemia in diabetic mice for 30 d. Sakata et al [46] also attempted to evaluate the therapeutic effect in renal function by transplantation of the device and confirmed an improvement of the hyperglycemia, serum blood urea nitrogen and creatinine and mesangial thickness.…”

Section: Resultsmentioning

confidence: 99%

Encapsulated islets transplantation: Past, present and future

Sakata

Sumi²,

Yoshimatsu³

et al. 2012

WJGP

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Islet transplantation could become an ideal treatment for severe diabetes to prevent hypoglycemia shock and irreversible diabetic complications, once some of the major and unresolved obstacles are overcome, including limited donor supplies and side effects caused by permanent immunosuppressant use. Approximately 30 years ago, some groups succeeded in improving the blood glucose of diabetic animals by transplanting encapsulated islets with semi-permeable membranes consisting of polymer. A semi-permeable membrane protects both the inner islets from mechanical stress and the recipient's immune system (both cellular and humoral immunities), while allowing bidirectional diffusion of nutrients, oxygen, glucose, hormones and wastes, i.e., immune-isolation. This device, which enables immune-isolation, is called encapsulated islets or bio-artificial pancreas. Encapsulation with a semipermeable membrane can provide some advantages: (1) this device protects transplanted cells from the recipient's immunity even if the xenogeneic islets (from large animals such as pig) or insulin-producing cells are derived from cells that have the potential for differentiation (some kinds of stem cells). In other words, the encapsulation technique can resolve the problem of limited donor supplies; and (2) encapsulation can reduce or prevent chronic administration of immunosuppressants and, therefore, important side effects otherwise induced by immunosuppressants. And now, many novel encapsulated islet systems have been developed and are being prepared for testing in a clinical setting.

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“…It has also been adapted to a hollow fiber conformation . Another hydrogel, polyvinyl alcohol, has been utilized for macroencapsulation and has demonstrated xeno‐protection for 2 months in a rodent model …”

Section: Capsule Structure and Compositionmentioning

confidence: 99%

Update on cellular encapsulation

Smith

Johnson

Papas

2018

Xenotransplantation

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There is currently a significant disparity between the number of patients who need lifesaving transplants and the number of donated human organs. Xenotransplantation is a way to address this disparity and attempts to enable the use of xenogeneic tissues have persisted for centuries. While immunologic incompatibilities have presented a persistent impediment to their use, encapsulation may represent a way forward for the use of cell-based xenogeneic therapeutics without the need for immunosuppression. In conjunction with modern innovations such as the use of bioprinting, incorporation of immune modulating molecules into capsule membranes, and genetic engineering, the application of xenogeneic cells to treat disorders ranging from pain to liver failure is becoming increasingly realistic. The present review discusses encapsulation in the context of xenotransplantation, focusing on the current status of clinical trials, persistent issues such as antigen shedding, oxygen availability, and donor selection, and recent developments that may address these limitations.

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Effect of Rat-to-Mouse Bioartificial Pancreas Xenotransplantation on Diabetic Renal Damage and Survival

Abstract: This study demonstrated that polyvinyl alcohol gel bioartificial pancreas transplantation can protect the kidney from diabetic damage.

Cited by 19 publications

References 29 publications

The in vivo performance of polyvinyl alcohol macro-encapsulated islets

The in vivo performance of polyvinyl alcohol macro-encapsulated islets

Encapsulated islets transplantation: Past, present and future

Update on cellular encapsulation

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