Effect of reaction time, heating and stirring rate on the morphology of HAp obtained by hydrothermal synthesis

Szterner, Piotr; Biernat, Monika

doi:10.1007/s10973-022-11564-5

Cited by 11 publications

(4 citation statements)

References 56 publications

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“…We can also conclude that Ca 2+ concentration is one of the most important parameters to be considered, regardless of the reaction type. Regarding the temperature of the process, in previous study [44,45] only a high temperature of 200 • C led to HAp whiskers, in contrast to the results reported here, which is another proof that this procedure allows for controlling ceramics' appearance and phase composition.…”

Section: Discussionsupporting

confidence: 54%

“…HAp was fabricated using the hydrothermal method, similar to our previous studies [44,45]. Syntheses were carried out in various conditions using a stainless steel reactor (Büchiglasuster ® , miniclave steel type 3/300 mL, 100 bar, Büchi AG, Uster, Switzerland).…”

Section: Synthesis Of Hapmentioning

confidence: 99%

“…It should be emphasized that the choice of this synthesis technique is because of the possibility of controlling the HAp crystal morphology and resulting product purity, which are the most important requirements for biomedical applications. In our previous works [44,45] we investigated HAp fabrication using calcium lactate pentahydrate and orthophosphoric acid and the effects of the process parameters such as reaction time and temperature on HAp morphology and phase composition.…”

Section: Introductionmentioning

confidence: 99%

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Morphology Control of Hydroxyapatite as a Potential Reinforcement for Orthopedic Biomaterials: The Hydrothermal Process

et al. 2023

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Hydroxyapatite (HAp) of different morphologies was prepared by the direct decomposition of calcium lactate pentahydrate chelates using dipotassium hydrogen phosphate under hydrothermal conditions. The proposed technique allows for precise control of the HAp crystals morphology and product purity, which are necessary for biomedical applications. The synthesis parameters such as reagent concentrations, pH, reaction time, temperature, pressure, and stirring rate were optimized in order to produce calcium phosphates (CaPs) ceramics with restricted morphologies and composition. As a result, we obtained hydroxyapatite in the form of whiskers, hexagonal rods, nano particles, flowers, and cylinders. The products were characterized according to their structure (FTIR and XRD), morphology (SEM), and functional properties, i.e., the specific surface area. The obtained results indicate that the reagent concentration and pH values have the greatest impact on the HAp properties; however, the proper combination of all the mentioned parameters should be considered when there is a need for a bioceramic with defined physicochemical properties and an appropriate morphology.

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Section: Discussionsupporting

confidence: 54%

Section: Synthesis Of Hapmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphology Control of Hydroxyapatite as a Potential Reinforcement for Orthopedic Biomaterials: The Hydrothermal Process

et al. 2023

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“…In comparison with high flow rate conditions, a lower flow rate ensures twice slower mixing of the precursors in the premixing stage and longer synthesis time in general. A similar dependence was observed also in ref .…”

Section: Resultsmentioning

confidence: 99%

Scalable Synthesis of Size-Tunable Hydroxyapatite Nanoparticles as Potential Nanofertilizers

Burve,

Loeschner,

Omura Lund

et al. 2024

ACS Appl. Nano Mater.

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Hydroxyapatite is a biocompatible material with various applications. To meet the demand for industrial use of this material, a rapid and upscalable process for the synthesis of hydroxyapatite nanoparticles was developed using an in-house developed two-stage continuous flow hydrothermal reactor. In the framework of this study, phase pure and highly crystalline 30 to 115 nm long hydroxyapatite nanorods were produced for potential use as nanofertilizers. The phase composition of the nanorods was confirmed by X-ray diffraction. Particle size and shape were investigated using transmission electron microscopy. Inductively coupled plasma mass spectrometry was used to determine the Ca:P ratio. It was shown that the use of a second mixing stage allows the particle length to be decreased down to 30 nm without compromising on crystallinity. In addition to using different mixing stages, adjusting the pH and controlling the flow speed allow wide range size tuning of the produced particles. The experimental setup allows for continuous synthesis of phase pure and highly crystalline hydroxyapatite nanorods, ensuring the reproducibility and scalability of the process. Dispersive behavior and dissolution in citrate buffer at a hydroponic pH of 5.5 were studied to evaluate further possibilities of applying produced NPs on the plants.

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3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction

Zhang,

Wang,

Gui

et al. 2024

Advanced Science

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Porous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bioactivity remains a major challenge. To address this issue, calcium sulfate is used to regulate the directional growth of hydroxyapatite grains during ceramic sintering. The in situ oriented grains can not only alleviate the stress concentration but also strengthen the bonding force between the ceramic grain boundaries. Calcium sulfate improves the release of active calcium ions from calcium phosphate ceramics, further enhancing their bioactivity and osteoinductivity in vivo. Transcriptome and proteome sequencing reveals that the in situ whisker‐reinforced ceramics increase the expression of proteins related to calcium ion binding and promote the expression of osteogenesis‐related proteins. In the supercritical bone defect repair model, repair of the defect is achieved within 3 months, with mechanical recovery reaching more than 70% of the autologous bone.

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Effect of reaction time, heating and stirring rate on the morphology of HAp obtained by hydrothermal synthesis

Cited by 11 publications

References 56 publications

Morphology Control of Hydroxyapatite as a Potential Reinforcement for Orthopedic Biomaterials: The Hydrothermal Process

Morphology Control of Hydroxyapatite as a Potential Reinforcement for Orthopedic Biomaterials: The Hydrothermal Process

Scalable Synthesis of Size-Tunable Hydroxyapatite Nanoparticles as Potential Nanofertilizers

3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction

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