1998
DOI: 10.1016/s0002-8703(98)70089-4
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Effect of recent cocaine use on the specificity of cardiac markers for diagnosis of acute myocardial infarction

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Cited by 79 publications
(29 citation statements)
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“…Conversely, a relatively normal appearing electrocardiogram may not be sufficient to rule out an MI. 32,33 The specificity of myoglobin as a marker of acute MI is altered by recent cocaine use. However, the specificity of creatine kinase MB (CK-MB) is affected less and that of cardiac troponin I is not affected by recent cocaine use.…”
Section: Clinical Presentation and Diagnosismentioning
confidence: 99%
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“…Conversely, a relatively normal appearing electrocardiogram may not be sufficient to rule out an MI. 32,33 The specificity of myoglobin as a marker of acute MI is altered by recent cocaine use. However, the specificity of creatine kinase MB (CK-MB) is affected less and that of cardiac troponin I is not affected by recent cocaine use.…”
Section: Clinical Presentation and Diagnosismentioning
confidence: 99%
“…However, the specificity of creatine kinase MB (CK-MB) is affected less and that of cardiac troponin I is not affected by recent cocaine use. 33 Because of the difficulty in being able to accurately assess patients with chest pain and recent cocaine usage, most emergency departments routinely admit such patients for monitoring. Chest pain observation units have been used successfully for the evaluation of cocaine users with potential cardiac symptoms.…”
Section: Clinical Presentation and Diagnosismentioning
confidence: 99%
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“…Hollander et al found that the specificity of cTnI was similar to that of CK-MB, and was significantly higher than that of myoglobin in 19 patients who had recently used cocaine. 21 McLaurin et al measured cTnI, cTnT, CK, and CK-MB in 19 patients after cocaine use. 20 Elevated CK and CK-MB were present in 14 and three patients, respectively, while none had troponin elevations.…”
Section: Discussionmentioning
confidence: 99%
“…Efforts to risk-stratify patients with cocaine-associated chest pain early in the ED course have been unsuccessful [7,[9][10][11]. Mittleman et al demonstrated that the greatest risk of AMI is within 60 minutes following cocaine use [12].…”
Section: Introductionmentioning
confidence: 99%