Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: a preliminary study in rabbit mandibles

Yonezawa, Hisanobu; Harada, Kiyoshi; Ikebe, Tetsurou; Shinohara, Masanori; Enomoto, S.

doi:10.1016/j.jcms.2006.02.003

Cited by 38 publications

(22 citation statements)

References 30 publications

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“…RhBMP-2 has been tested in many studies and showed osseoinductive effects (Raghoebar et al, 1993;Boyne and Shabahang, 2001;Schwartz et al, 2008). Yonezawa et al (2006) evaluated the effect of rhBMP-2 on bone consolidation of distraction osteogenesis in rabbit mandibles and observed that the addition of BMP promotes better bone formation. Moreover the application of BMP in irradiated rat mandibles resulted in predictable bone generation (Springer et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep

Gutwald

Haberstroh

Stricker

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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SUMMARY.Background: Several studies have reported certain bone morphogenic proteins (BMPs) to have positive effects on bone generation. Although some investigators have studied the effects of human recombinant BMP (rhBMP-2) in sinus augmentation in sheep, none of these studies looked at the placement of implants at the time of sinus augmentation. Furthermore, no literature could be found to report on the impact that different implant systems, as well as the positioning of the implants had on bone formation if rhBMP-2 was utilized in sinus-lift procedures. Purpose: The aim of this study was to compare sinus augmentation with rhBMP-2 on a poly-D, L-lactic-co-glycolic acid gelatine (PLPG) sponge with sinus augmentation with autologous pelvic cancellous bone in the maxillary sinus during the placement of different dental implants. Materials and methods: Nine adult female sheep were submitted to bilateral sinus-floor elevation. In one side (test group) the sinus lift was performed with rhBMP-2 on a PLPG-sponge, while the contralateral side served as the control by using cancellous bone from the iliac crest. Three different implants (Bränemark Ò , 3i Ò and Straumann Ò ) were inserted either simultaneously with the sinus augmentation or as a two staged procedure 6 weeks later. The animals were sacrificed at 6 and 12 weeks for histological and histomorphometrical evaluations during which boneto-implant contact (BIC) and bone density (BD) were evaluated. Results: BD and BIC were significantly higher at 12 weeks in the test group if the implants were placed at the time of the sinus lift (p \ 0.05). No difference was observed between the different implant systems or positions. Conclusions: The use of rhBMP-2 with PLPG-sponge increased BIC as well as BD in the augmented sinuses if compared to autologous bone. Different implant systems and positions of the implants had no effect on BIC or BD. Ó 2010 European Association for Cranio-Maxillo-Facial Surgery

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Section: Introductionmentioning

confidence: 99%

Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep

Gutwald

Haberstroh

Stricker

et al. 2010

Journal of Cranio-Maxillofacial Surgery

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“…Yonezawa et al [29] and Padovan et al [18], in studies with the use of morphogenetic proteins, demonstrated positive results in terms of bone formation and density, implying a significant rehabilitation for critical defects and alveolar bone grafting.…”

Section: Discussionmentioning

confidence: 99%

“…Since the discovery of rhBMP, several studies have demonstrated the biological advantages of rhBMP-2 and significant rehabilitation on bone formation in studies both on rats and humans, which takes about six months [29].…”

Section: Advantages Of Rhbmp-2mentioning

confidence: 99%

Application of BMP-2 for bone graft in Dentistry

Valadas

Júnior

Lotif

et al. 2016

RSBO

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Introduction: The global increase life expectancy and the resulting tooth loss has required searching for new rehabilitation alternatives in Dentistry. Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. Objective: To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. Material and methods: The following databases were searched: Pubmed, Bireme, Lilacs, and Scielo and 30 articles published between 1965 and 2013 were found using the following descriptors: "dental implants", "maxillary sinus", and "biocompatible materials". Results: Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. In recent years, morphogenetic protein has presented a large clinical use. Conclusion: Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face.

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“…A eficácia de aumento do osso vertical foi avaliada no osso craniano de 15 coelhos, revelando que um bloco córtico-esponjoso de osso humano, agre-gado com rhBMP-2, poderia ser uma opção de tratamento alternativo para aumento ósseo vertical 61 . Para examinar a eficácia de rhBMP-2 em distração osteogênica, os autores relataram a consolidação óssea em 21 coelhos, sugerindo que a rhB-MP-2 promove a formação de osso em distração osteogênica 62 . Ao se comparar o aumento do seio maxilar, um grupo com rhBMP-2 em uma esponja de gelatina (PLPG) e outro com osso pélvico esponjoso autólogo, durante a colocação de diferente sistemas de implantes dentários, foi realizado um estudo em nove ovelhas adultas, realizando avaliações de contato implante-osso (BIC) e densidade óssea (BD).…”

Section: Revisão De Literaturaunclassified

Aplicabilidade de rhBMP-2 em diferentes técnicas de enxertia

Pasquali

Casagrande

Ponte

et al. 2015

Rev. da Fac. de Odontologia, UPF

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IntroduçãoTécnicas de enxerto ósseo surgiram para suprir perdas de volume nos sentidos horizontais e verticais, em pacientes com quantidade óssea reduzida, visto que o sucesso de reabilitações bucofaciais depende não somente do treinamento e da experiên-cia do profissional, mas também da quantidade e da densidade de osso disponível 1,2 . O tecido ósseo tem as seguintes propriedades de reparação e formação: osteogênese que é a formação óssea mediada por osteoblastos; osteoindução, mediada por BMPs, induzindo a formação óssea ectópica por meio de células mesenquimais; e osteocondução, relacionado à composição e à estrutura (arcabouço). Tais propriedades têm papel importante nos diferentes mecanismos de formação óssea dos enxertos, os quais podem ter diferentes origens: autógenos, homógeno, xenógeno e aloplásticos [3][4][5][6] . Osso autógeno ainda é o "padrão ouro" para procedimentos de reconstrução 7 , apesar da grande morbidade 8 . Em estudos recentes, pesquisadores isolaram a principal proteína para regeneração óssea, a proteína morfogenética (BMP), e derivaram sinteticamente a Proteínas Morfogenéticas Ósseas Recombinantes Humanas (rhBMP-2). Essa proteína funciona como regulador de crescimento e diferenciação celular, induzindo a transformação de células-tronco em células produtoras de tecidos ósseos ou vasculares 3,6 . Objetivo: analisar a influência da rhBMP-2 em enxertos bucofaciais, apresentando pesquisas recentes, feitas em animais e em humanos, bem como as diferentes metodologias de aplicabilidade clínica e os resultados obtidos por seus autores. Revisão de literatura: para que seja possível a instalação de implantes ou a cor-

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Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: a preliminary study in rabbit mandibles

Cited by 38 publications

References 30 publications

Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep

Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep

Application of BMP-2 for bone graft in Dentistry

Aplicabilidade de rhBMP-2 em diferentes técnicas de enxertia

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