Effect of Recombinant Human Tumor-Necrosis-Factor-Alpha and Dequalinium Chloride on Human Ovarian-Cancer Cell-Lines in-Vitro

Manetta, Alberto; Emma, Dennis; Fuchtner, Carlos; Gamboa-Vujicic, Gisela; Paredes, Pilar; Lucci, Joseph A.; Gatanaga, Tetsuya; Granger, G.

doi:10.3892/ijo.3.1.127

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“…After the administration of DQA, the survival rate of mice with PA‐1 intraperitoneal ovarian cancer xenograft was extended 57 . In other similar animal studies, DQA as a mitochondrial toxicant has shown a synergistic effect with TNF, which enhances the effect of TNF against ovarian cancer cell lines 57 . Endometrial cancer is the most common malignant tumour in the female pelvis 58 .…”

Section: Dqa and Solid Tumoursmentioning

confidence: 96%

“…Ovarian cancer is the seventh most common cancer among women and the eighth‐most common cause of cancer deaths worldwide 56 . After the administration of DQA, the survival rate of mice with PA‐1 intraperitoneal ovarian cancer xenograft was extended 57 . In other similar animal studies, DQA as a mitochondrial toxicant has shown a synergistic effect with TNF, which enhances the effect of TNF against ovarian cancer cell lines 57 .…”

Section: Dqa and Solid Tumoursmentioning

confidence: 98%

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The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Pan

Zhao

Chen

2021

Clin Exp Pharma Physio

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Dequalinium chloride has been known as one kind of antibiotic that displays a broad antimicrobial spectrum and has been clinically proven to be very safe. In recent years, studies have shown that dequalinium chloride can inhibit the growth of malignant tumours, and reports were mainly used for solid tumours. Glioblastoma is the most common malignant neuroepithelial tumour of the central nervous system in adults, and the prognosis of glioblastoma is poor as it has a high resistance to apoptosis. This review summarizes the current understanding of dequalinium chloride‐induced cancer cell apoptosis and its potential role in glioblastoma resistance and progression. Particularly, we focus on dequalinium chloride as it exerts a wide range of anti‐cancer activity through its ability to target and accumulate in the mitochondria, and it effectively inhibits the growth of glioblastoma cells in vitro and vivo. Dequalinium chloride is an inhibitor of XIAP and can also act as a mitochondrial targeting agent, which gives it an interesting perspective regarding recent advances in the treatment of malignant glioma.

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Section: Dqa and Solid Tumoursmentioning

confidence: 96%