Effect of recombinant interferon-alpha on bleomycin-induced chromosome damage in hamster cells

The Effects of Pegylated Interferon Alpha-2a and Alpha-2b Therapy on Chromosomal Aberrations and Mitotic Index in Patients with Chronic Hepatitis B

“…When we compared our studies with the other studies that investigated the effect of interferon therapy in terms of chromosomal aberrations and MI, our results were similar to those of Ozturk et al and Bolzan et al while they were not similar to those of Jasny and Tamm in terms of frequency of chromosomal aberrations. 7,32,34 For the MI, our results were not similar to the results of Ozturk et al and Georgian et al 7,35 These results represent critical and meaningful data. Although hepatitis B virus has a genotoxic effect, interferon therapy for 6 months does not lead to increased cytogenetic aberrations or decreased MI.…”

“…31 Bolzan et al determined that recombinant interferon alpha-2a has an inhibitor activity against chromosomal aberrations that was induced by bleomycin therapy in hamsters. 32 Mertens et al carried out an in vitro study in amniotic fluid cells and showed that recombinant interferon alpha and beta reduced dose-related sister chromatid exchange. 33 Higano et al achieved permanent cytogenetic remission by interferon alpha-2a therapy without life-threatening toxicity in patients with chronic myeloid leukemia who relapsed subsequent to bone marrow transplantation.…”