Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women

Abstract

Objective. Evaluate in postmenopausal women the effect of red clover extract (RCE) isoflavones over subjective status of skin, appendages, and several mucosal sites. Method. Postmenopausal women (n = 109) were randomly assigned to receive either two daily capsules of the active compound (80 mg RCE, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Subjective improvement of skin, appendages, and several mucosal site status was assessed for each studied group at 90 and 187 days using a visual analogue scale (VAS). In addition, libido, tiredness, and urinary, sleep, and mood complaints were also evaluated. Results. Women after RCE intervention (both groups) reported better subjective improvement of scalp hair and skin status, libido, mood, sleep, and tiredness. Improvement of urinary complaints, nail, body hair, and mucosa (oral, nasal, and ocular) status did not differ between treatment phases (intra- and intergroup). Overall satisfaction with treatment was reported higher after RCE intervention (both groups) as compared to placebo. Conclusion. RCE supplementation exerted a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.

Trifolium species – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties

“…Currently, extracts of red clover are available as dietary supplements, recommended as an alternative to the conventional hormone replacement therapy. On the other hand, clinical data collected in the previous review provided disputable results concerning the efficacy of red clover isoflavone administration (Table ) . Moreover, the bioavailability of clover‐derived substances and the possibility of their interactions with other medications are only partly elucidated.…”

“…On the other hand, clinical data collected in the previous review [1] provided disputable results concerning the efficacy of red clover isoflavone administration (Table 4). [62][63][64][65] Moreover, the bioavailability of clover-derived substances and the possibility of their interactions with other medications are only partly elucidated. Results providing some new information about bioavailability of red clover isoflavones in humans were published by Lipovac and co-authors in 2015.…”

“…Randomized clinical investigation 80 mg of Red clover isoflavones for 90 days Improvement in scalp hair and skin status, libido, mood, sleep and tiredness in postmenopausal women [64] Red clover extract A prospective, randomized, double-blind, placebo-controlled study 12-Month therapy with 40 mg of red clover isoflavones/day Lack of considerable improvement in menopausal symptoms and sexual satisfaction [65] and six parallel examinations) were included into the metaanalysis. The selected trials included administration of red clover isoflavones (40 mg/day for 3 months), T. pratense extract (40 mg/day for 4 months) or red clover-based commercial preparation (Promensil â , at doses of 40-160 mg/day, for 3-12 months).…”

COMPARISON OF EFFECT OF RED CLOVER & CONJUGATED ESTROGEN ON MENOPAUSAL SYMPTOMS AND THEIR IMPACT ON QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN

“…[13] Red clover has good safety profile, no significant side effects are mentioned in studied literature. [14] Analysis of the menopause rating scale in the present study showed that both the groups were comparable regarding the reduction of menopause rating scale and there was no statistically [15] In another study done by Ehsanpour et al, a total of 55 women completed the study, 28 subjects in red clover and 27 in placebo group. Mean score of total quality of life (p < 0.001 in both groups), mean score of quality of life in vasomotor domain (p < 0.001 in both groups), psycho-social domain (p < 0.001 in red clover and p = 0.02 in placebo group) and physical domain (p < 0.001 red clover and p = 0.01 placebo group) significantly reduced compared to the baseline values.…”

The action of herbal medicine on the libido: aspects of nutritional intervention in increasing sexual desire

“…[29] Red clover F (113) ↑ Estrogen levels and benefits to specific organs or systems. [30] Low-energy diet and low-fat, high-protein diet M (31) Diet ↑ testosterone and improves sexual function.…”