Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats

Xu, Limin; Li, Zhigang; Rong, Junbo; Lang, Lijuan

doi:10.1002/jbt.22841

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Studies in the literature report that VEP in amblyopia results in generally lower amplitude and prolonged latency, especially in advanced amblyopia. 10,28 P2 latency was prolonged and P2 amplitude was reduced in the MD group when compared with the Nor group (unpaired student's t-test). There was no change in the P2 latency and amplitudes measurements among the normal groups (Nor vs. Nor+DMSO vs. Nor+rolipram, one-way ANOVA, p>0.05).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Rolipram on Visual Cortical Plasticity in Amblyopia Model: Experimental Animal Study

EMRE,

KATRE,

ALTINTAŞ

et al. 2023

Turkiye Klinikleri J Ophthalmol

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Electrophysiological and electron microscopic investigation of the effect of rolipram on visual cortical plasticity in a monocular deprived rat model. Material and Methods: Twenty-four female Wistar albino rats were randomly assigned into 6 groups, 4 rats in each. The right eyelids of all rats except the control group were sutured to induce amblyopia. We subjected rats at postnatal day 21 to a monocular deprivation (MD) model until postnatal day 45. Then, the deprived eyes of the MD model rats were reopened' cümlesi çıkarılarak 'On day 46, the deprived eyes of the rats were opened.On day 46, the deprived eyes of the rats were opened. Rats were treated with rolipram or vehicle for 10 days. The ultrastructural modifications in the synaptic junction and the changes to the visual evoked potentials (VEP) were analyzed. Results: In flash VEP, the P2 latency was prolonged and the P2 amplitude was reduced in monocularly deprived rats. With rolipram treatment, the P2 latency became shorter and the amplitude increased. In the monocularly deprived rats, the ultrastructural analysis showed that the synapses in the pyramidal neurons were impaired, the synaptic clefts were expanded, the synaptic active zones were shorter, and the thicknesses of the postsynaptic density were decreased. However, rolipram treatment improved all of the structural indices in the MD rats. Conclusion: This study shows that rolipram provides structural and functional improvement in visual cortex in amblyopia model in rats. Rolipram shows promise in the treatment of amblyopia and more research is needed.

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Section: Discussionmentioning

confidence: 99%

The Effect of Rolipram on Visual Cortical Plasticity in Amblyopia Model: Experimental Animal Study

EMRE,

KATRE,

ALTINTAŞ

et al. 2023

Turkiye Klinikleri J Ophthalmol

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“…Previous studies have shown that there are structural changes in ganglion cells, lateral geniculate body and visual cortex of amblyopia animals, accompanied by a decrease in synaptic density, and these structural changes will lead to further changes in their functions [39][40][41] . Studies have shown that the synaptic density of visual cortex in amblyopia animals decreased compared with that in normal animals, accompanied by changes in tissue morphology.…”

Section: Discussionmentioning

confidence: 99%

“…strabismus, anisometropia) will disturb the physiological tissues of visual pathway, leading to loss of visual responses in cortical neurons and reduction in visual acuity of the affected eye, so that it becomes amblyopic 43 . Apoptosis level is generally considered to be highly correlated with amblyopia 40,44 . Similarly, by TUNEL apoptosis detection, we found that the level of apoptosis of visual cortex neurons in the deprivation group was higher than that in the control group at the 8th week of age.…”

Section: Discussionmentioning

confidence: 99%

Relationship between monocular form deprivation amblyopia and activity-regulated cytoskeleton-associated in visual cortex of kittens

Fan

Wang

Zou

et al. 2022

Preprint

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Purpose Exploring the role of activity-regulated cytoskeleton-associated (Arc) in visual cortex in visual development, and studying its expression changes in amblyopia kittens. Methods Fifteen 3-week-old kittens were randomly selected from the deprivation group and the control group, and raised in the natural environment. Black opaque covering cloth was used to cover the right eye of deprived kittens. Pattern visual evoked potentials (PVEP) was detected at the 3rd, 4th, 6th and 8th weeks of age, and 5 kittens were randomly selected from each group and euthanized after each detection. The Arc expression both at mRNA and protein levels was assessed using in situ hybridization and immunohistochemistry analyses. Apoptosis of visual cortex cells in 8-week-old kittens was detected by TUNEL. Results With the increase of age, the expression of Arc gene in visual cortex of both the deprivation group and the control group showed an upward trend, but the upward trend of the control group was more obvious. At the age of 8 weeks, the expression of Arc protein (P < 0.05) and mRNA (P < 0.05) in visual cortex of deprived kittens was lower than that of control kittens. Moreover, the number of apoptosis in visual cortex of deprivation group was higher than that of control group (P < 0.05). Correlation analysis shows that the expression of Arc gene was negatively correlated with the apoptosis level of visual cortex neurons. Conclusions The expression of Arc is associated with monocular form deprivation amblyopia and affects the apoptosis of visual cortex cells.

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“…Related studies believe that visual developmental plasticity is the basis of amblyopia treatment, and its performance is closely related to synaptic plasticity [1,2]. During the occurrence and development of amblyopia, the synaptic density in ganglion cells, lateral geniculate body, and visual cortex of animals changed [3][4][5]. Synapse, as the structural basis of information transmission between neurons, is the key part of visual development plasticity [6].…”

Section: Introductionmentioning

confidence: 99%

ARC/Arg3.1 expression in the lateral geniculate body of monocular form deprivation amblyopic kittens

et al. 2023

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Purpose The present study compared the expression of activity-regulated cytoskeleton-associated protein (ARC/Arg3.1) in the lateral geniculate body between form deprivation amblyopia kittens and normal kittens to examine the significance of ARC/Arg3.1 in the lateral geniculate body in the pathogenesis of amblyopia. Methods Twenty kittens were randomly divided into an experimental group (n = 10) and a control group (n = 10). Black opaque covering cloth was used to cover the right eye of kittens in the experimental group. Pattern visual evoked potentials (PVEP) were detected weekly in all kittens. The expression of the ARC/Arg3.1 gene was detected by immunohistochemistry and in situ hybridization, and apoptosis of lateral geniculate body cells was detected by TUNEL. Results PVEP detection showed that at the age of 5 and 7 weeks, the latency of P100 in the right eye of the experimental group was higher than that of the other three groups (P < 0.05), and the amplitude of P100 was lower than that of the other three groups (P < 0.05). The expression of ARC/Arg3.1 protein (P < 0.05) and mRNA (P < 0.05) in the lateral geniculate body of the experimental group was significantly lower than that of the control group. The level of neuronal apoptosis in the experimental group was higher than that in the control group (P < 0.05). The expression of the ARC/Arg3.1 gene was negatively correlated with the apoptosis level of lateral geniculate body neurons. Conclusions The expression of ARC/Arg3.1 is associated with monocular form deprivation amblyopia and apoptosis of lateral geniculate body cells.

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Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats

Cited by 4 publications

References 32 publications

The Effect of Rolipram on Visual Cortical Plasticity in Amblyopia Model: Experimental Animal Study

The Effect of Rolipram on Visual Cortical Plasticity in Amblyopia Model: Experimental Animal Study

Relationship between monocular form deprivation amblyopia and activity-regulated cytoskeleton-associated in visual cortex of kittens

ARC/Arg3.1 expression in the lateral geniculate body of monocular form deprivation amblyopic kittens

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