Using the convenient sampling method, the control group and the observation group were established. The control group was given a routine nursing scheme, while the observation group was given rehabilitation nursing scheme. The difference of curative effect between the two groups were compared and the results were analyzed and summarized. Results of the quality of life scores of patients in the two groups were compared. The results showed that the quality of life score of the patients in the observation group were higher than that of the control group (P<0.05); the satisfaction scores of patients was also compared. The results showed that the satisfaction scores of patients in the experimental group were significantly higher than that in the control group (P<0.05), so the patients in the observation group are better than the control group. The rehabilitation nursing scheme has a certain effect on the rehabilitation of knee ligament injury of printing workers.