Effect of renal transplantation on sperm quality and sex hormone levels

Akbari, Fatemeh; Alavi, Mehrdad; Esteghamati, Abdoulreza; Mehrsai, Abdolrasoul; Djaladat, Hooman; Zohrevand, R.; Pourmand, Gholamreza

doi:10.1046/j.1464-410x.2003.04323.x

Cited by 103 publications

(67 citation statements)

References 14 publications

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“…The testis is marked by several signs of histologic injury, including germinal aplasia and seminiferous tubule destruction, the extent of which determines the reversibility after transplantation (8,16). Transplantation restores the balance in the hypothalamic-pituitary axis and consequently is associated with improvements in sperm motility but not in sperm counts or morphology (17). The true incidence and prevalence of infertility are difficult to determine, and it is unknown whether immunosuppressive medications have an independent effect on fertility of the recipient, although calcineurin inhibitors (CNI) and azathioprine do not seem to alter male fertility after transplantation (18).…”

Section: Fertility Contraception and Optimal Timing Of Pregnancymentioning

confidence: 99%

Pregnancy after Kidney Transplantation

McKay

Josephson²

2008

Clinical Journal of the American Society of Nephrology

129

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Reproductive success is a common, expected outcome for male and female recipients of solid-organ transplants. Men can father children, and women can become pregnant and carry the fetus to delivery. There are, however, important maternal and fetal complications that need to be considered to provide optimal care to the mother and her infant. Although pregnancy is common after the transplantation of all solid organs, guidelines for optimal counseling and clinical management are limited. This review discusses information to help the physician counsel the kidney transplant recipient about risks of pregnancy for the mother and the fetus and provides information to help guide treatment of the pregnant transplant recipient.

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Section: Fertility Contraception and Optimal Timing Of Pregnancymentioning

confidence: 99%

Pregnancy after Kidney Transplantation

McKay

Josephson²

2008

Clinical Journal of the American Society of Nephrology

129

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“…In the literature Kidney transplant and cavernosal arteries P Gontero et al 624 there is no consensus on hormonal variations after renal transplantation. Akbari et al 26 found that hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal, in contrast to the results of Shamsa et al, 7 who described significant decreases in mean testosterone and prolactin levels after KT.…”

Section: Discussionmentioning

confidence: 86%

Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?

Gontero

Oderda²,

Filippini³

et al. 2011

Asian J Androl

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Reduced cavernosal arterial inflow has been hypothesized to be the likely cause of erectile dysfunction after kidney transplants in recipients revascularized through end-to-end anastomosis to the internal iliac artery, suggesting that end-to-side anastomosis at the external iliac artery is preferable. The aim of this study was to prospectively evaluate the effect of the use of the external iliac artery on erectile function, hormone profiles and penile blood flow by evaluating changes in penile colour Doppler ultrasound parameters in a consecutive series of 22 recipients before and after end-to-side external iliac artery transplantation. The mean International Index of Erectile Function-Erectile Function (IIEF-EF) domain score decreased significantly 3 months after transplant (18.0966.33 vs. 22.5067.09, P50.01). The reduction in peak systolic velocity (PSV) was significant for the cavernous artery homolateral to the side of transplant (42.60618.77 vs. 52.01619.91, P50.01). The mean postoperative end diastolic velocity (EDV) did not differ significantly from the preoperative value (P50.74). No statistical differences were found in the serum levels of testosterone or prolactin. Kidney grafts anastomosed at the external iliac artery produced significant (P50.01) reductions in arterial inflow at the homolateral cavernosal artery that remained above the normal threshold. Whether these haemodynamic changes can explain the worsening of postoperative erectile function remains to be proven.

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“…The serum prolactin concentrations in response to TRH were slightly elevated because of the decreased clearance of prolactin in chronic renal failure except just after the operation (Fig. 1A, 1C) [3].…”

Section: A B Cmentioning

confidence: 97%

A case of TSH-producing adenoma treated with octreotide in combination with thiamazole for the control of TSH and thyroid hormones after trans-sphenoidal neurosurgery

et al. 2011

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Thyroid-sTimulaTing hormone (TSH) -producing pituitary adenomas (TSHoma) are rare, accounting for 0.5-1.1% of all pituitary adenomas [1,2]. The diagnosis of these adenomas can be delayed and most TSH-producing adenomas are macroadenomas [1]. Herein, we report a patient with chronic heart and renal failure who was diagnosed with TSH-producing adenoma and underwent treatment with octreotide and thiamazole to control the level of TSH and thyroid hormone secretion after pituitary trans-sphenoidal surgery.A case of TSH-producing adenoma treated with octreotide in combination with thiamazole for the control of TSH and thyroid hormones after trans-sphenoidal neurosurgery Sayaka Fukushima 1) , Masaki Takahashi 2) , Chihiro Yoneda 1) , Hiroyuki Matsuura 1) , Takenori Haruki 1) , Jun Ogino 1) , Minako Koike 2) , Osami Kubo 4) , Takakazu Kawamata 3) and Naotake Hashimoto 1) abstract. While TSH-producing adenoma (TSHoma) is rare, the diagnosis is often delayed because the clinical features are heterogeneous. The patient was a 69-year-old woman who had been referred to the Yachiyo Medical Center in August 2008, because of dyspnea, loss of appetite, weight loss of 10 kg, and diarrhea that lasted 4 years. We diagnosed this patient with pituitary TSH-producing macroadenoma. Thyroid hormone concentration was increasing although the serum TSH level was within a normal range after trans-sphenoidal surgery. We considered that because of enlargement of the thyroid gland due to long-term stimulation by TSH, a low concentration of TSH could stimulate the thyroid gland to produce excess T3 or T4. The somatostatin analogue, octreotide was used to control the TSHoma and serum TSH concentration but not thyroid hormone. The octreotide in combination with thiamazole treatment for 14 months controlled thyroid hormone concentration and decreased the thyroid mass, and ultimately, the thiamazole could be stopped. To date, the use of combination therapy of octreotide with thiamazole in patients with remaining TSH-producing adenoma without Basedow's disease is rare, and we suggest that this treatment is one of the therapeutic means to treat recurrence of TSH-producing adenoma after surgery with progressive complications or large thyroid gland.

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Effect of renal transplantation on sperm quality and sex hormone levels

Cited by 103 publications

References 14 publications

Pregnancy after Kidney Transplantation

Pregnancy after Kidney Transplantation

Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?

A case of TSH-producing adenoma treated with octreotide in combination with thiamazole for the control of TSH and thyroid hormones after trans-sphenoidal neurosurgery

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