Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Dar, Muneer Ahmad; Khan, Azmat Alam; Raina, Rajinder; Beigh, S.A.; Sultana, Mudasir

doi:10.1080/02772248.2015.1070160

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…These features are considered to be the reasons for the high neuroprotective activity observed above [29,34]. Since the fermentation extracts and β-carotene showed high neuroprotective activity in the above results, it is possible to expect the correlation between the activities against oxidative stress and the neuroprotective activity, which can derive a neuroprotective mechanism that is associated with antioxidant activities, whose mechanism was also proposed in other works [25,35,36]. To confirm this hypothesis, the reduction of ROS production was also observed in this work, because this treatment induces oxidative damage, Ca 2+ ions induce ROS activity, and Glutathione (GSH) inhibits ROS formation [36].…”

Section: Discussionsupporting

confidence: 65%

“…The enzyme activity of glutathione was measured at 412 nm after adding 1 mM NADPH to 1.0 mL of a solution containing 100 µg of the sample, 0.1 M sodium phosphate buffer (pH 7.6), 1 mM EDTA, 1 mM GSSG and 0.6 mM 5,5 -dithiobis-2-nitrobenzoic acid (DTNB). The activity of glutathione reductase was also measured by calculating the ratio of the production of 2-nitro-3-thiobenzoic acid from DTNB during the reduction of glutathione [25,26].…”

Section: Measurement Of Glutathione Peroxidase and Glutathione Reductmentioning

confidence: 99%

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Enhancement of the Neuroprotective Effect of Fermented Spirulina maxima Associated with Antioxidant Activities by Ultrasonic Extraction

et al. 2018

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This study is the first demonstration of the neuroprotective activity of the marine alga, Spirulina maxima, fermented by Lactobacillus plantarum HY-08, which was freshly isolated from fermented vegetables. The combined process of the fermentation with ultrasonic extraction at 40 kHz for 4 hr greatly increased the amounts of β-carotene in the extract up to 1.62 mg/g, along with a high extraction yield of 18.26%, compared to 1.03 mg/g and 12.8% from ultrasonic extraction itself, and even much higher than 0.81 mg/g and 10.6% from conventional water extraction. It was also proved that the neuroprotective activities of the extract were enhanced possibly by higher contents of β-carotene in the extract, compared to those from water extraction or ultrasonic extraction itself. This extract was found to have strong antioxidant properties, with 49.01% 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, which resulted in 90.30% neuroprotective activity. Specifically, the fermented extract markedly enhanced the brain-derived neurotrophic factor (BDNF)/p-CREB signaling pathways, which can effectively prevent memory impairment in mice caused by oxidative stress. β-Carotene also increased the expression of p-CREB and BDNF, and a mechanism of their upregulation by β-carotene is first proposed in this study. It can be concluded that the strong neuroprotective effect of the extract was markedly influenced by the antioxidant activities, due to the synergistic effects of high amounts of β-carotene and other biologically active substances in the extract that can be obtained by lactic acid fermentation, combined with ultrasonic processing.

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Section: Discussionsupporting

confidence: 65%

Section: Measurement Of Glutathione Peroxidase and Glutathione Reductmentioning

confidence: 99%

Enhancement of the Neuroprotective Effect of Fermented Spirulina maxima Associated with Antioxidant Activities by Ultrasonic Extraction

et al. 2018

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“…Noeman et al [35] and Dar et al [36] also observed in their respective studies that the MDA cross linking and oxidative damage can also cause the inhibition of AChE enzyme due to the different pollutants like insecticides. The level of AChE in the brain, blood and erythrocytes was decreased with the increasing dose of bifenthrin, it indicates that bifenthrin has a higher tendency to inhibit AChE.…”

Section: Discussionmentioning

confidence: 95%

Neurotransmitter and Histopathological Alteration Induced by Bifenthrin in the Brain of <em>Oryctologus cuniculus</em>

Tayyab,

Noman,

Nasir

2023

Preprint

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Bifenthrin is a synthetic pyrethroid insecticide. It is used worldwide against different agricultural pests. Nervous system (NS) is the primary target organ for the pyrethroid group of insecticide which causes hyper excitation. The aim of this study to determine the effects of bifenthrin on the brain of rabbits. The animals were treated for 14 days with three different doses (1/5th, 1/10th and 1/15th of LD50) of bifenthrin. Neurotransmitters and Histopathological alterations were observed at the end of the experiments. Neurochemical parameters were checked 24 hours after the last dose. Significant changes in the level of biogenic amines were observed. The levels of epinephrine (EPN), dopamine (DA), 3, 4 dihydroxyphenylacetic acid (DOPAC) were decreased as compared to controls group with the increase in insecticide. However, norepinephrine (NE) and homovanillic acid (HVA) levels were found to be significantly higher than those of the controls. A significant reduction in the activity of the acetyl cholinesterase enzyme was found in the frontal cortex’s erythrocyte, plasma and brain of rabbit with the increase in administered bifenthrin. The oxidative stress showed significantly decrease in the activity of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and glutathione S- transferase (GST) with the increase in dose of bifenthrin. Histopathological study of brain tissues showed normal GC (glial cells) and NC (neuronal cells) in the frontal cortex of brain tissue of control groups while the treated groups showed evacuation (odema), elongation of pyramidal nucleus, glial cell damage and brain haemorrhage.

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“…Rats treated with LD 50 of permethrin and cypermethrin showed elevated activity of AChE in specific regions of the brain and inhibited activity in other regions [17]. Some reports show that bifenthrin treatment induced a decrease of AChE activity [18], while others show no effect of this pyrethroid on AChE activity in rats [19]. Xylene was reported to cause changes in neuronal cells, such as increased levels of dopamine or catecholamine and reduced axonal transport in rat brains [20][21].…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Insecticide Carrier Solvent: Effect of Xylene on Hemolymph Biochemical Parameters in Blaberus giganteus L.

Maliszewska¹,

Tęgowska²

2018

Pol. J. Environ. Stud.

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Xylene is an aromatic hydrocarbon occurring naturally in petroleum, coal, and wood tar. It is one of the top 30 chemicals produced in the United States in terms of volume. The annual production of xylene is estimated to be 16 million tons. Xylene is widely used as a solvent for paints, lacquers, glues, and pesticides, as well as in histological laboratories. Xylene is also found in airplane fuel, gasoline, and cigarette smoke [1-2]. In Poland, the threshold limit value for workers is 100 mg/m 3. It was estimated that hospital laboratory workers may be exposed to xylene in concentrations reaching 1,740 mg/m 3 , while printing house workers may be exposed to xylene in concentrations of about 130 mg/m 3 [3]. One can also come into contact with xylene through cigarette smoke, paints, automobile exhaust, and a variety of other consumer products [2]. Commercial products contain non-insecticidal ingredients that act as adjuvants, solvents, emulsifiers, or preservatives and which are not needed to be identified on the product label unless classified as highly toxic [4]. Many insecticide formulations contain 25 to 75 percent of solvent mixtures, and xylene and other aromatic hydrocarbons are frequently employed as solvents in pesticide concentrates [5]. Brattsten and Wilkinson [6] in experiments performed on southern armyworm demonstrated that, paradoxically, the carrier solvent in which the insecticide is formulated may aid in the

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Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Cited by 8 publications

References 30 publications

Enhancement of the Neuroprotective Effect of Fermented Spirulina maxima Associated with Antioxidant Activities by Ultrasonic Extraction

Enhancement of the Neuroprotective Effect of Fermented Spirulina maxima Associated with Antioxidant Activities by Ultrasonic Extraction

Neurotransmitter and Histopathological Alteration Induced by Bifenthrin in the Brain of <em>Oryctologus cuniculus</em>

Toxicity of Insecticide Carrier Solvent: Effect of Xylene on Hemolymph Biochemical Parameters in Blaberus giganteus L.

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