Effect of repeated restraint stress on the levels of intestinal IgA in mice

Jarillo-Luna, Adriana; Rivera-Aguilar, Víctor; Garfias, Humberto Reyna; Lara‐Padilla, Eleazar; Kormanovsky, Alexander; Campos-Rodrı́guez, Rafael

doi:10.1016/j.psyneuen.2007.04.009

Cited by 68 publications

(58 citation statements)

References 90 publications

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“…However, the majority of these studies have examined the impact of stress on the immune response within the gastrointestinal mucosa. Recently, psychological stress during gastrointestinal infection has been demonstrated to reduce the concentration of intestinal IgA (Jarillo-Luna et al, 2007), the numbers of intraepithelial lymphocytes (Jarillo-Luna et al, 2008), and the production of interferon-γ (IFN-γ) (Yang et al, 2006). Our laboratory has recently shown that psychological stress reduces the number of immune cells responsible for limiting mucosal HSV infection via the intranasal route (Ashcraft et al, 2008), resulting in increased viral replication.…”

Section: Introductionmentioning

confidence: 99%

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Ashcraft¹,

Bonneau²

2008

Brain, Behavior, and Immunity

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Chronic psychological stress is generally immunosuppressive and contributes to an increase in herpes simplex virus (HSV) pathogenicity. We have previously shown that mice experiencing stress at the time of intranasal HSV infection have increased levels of infectious virus in their nasal cavity, as compared to control mice that were not subjected to stress. We have extended our studies to determine the effects of stress at another clinically-relevant mucosal site by examining the immune response to and pathogenesis of vaginal HSV infection. Mice experiencing psychological stress during vaginal HSV infection exhibited an increase in both vaginal viral titers and the pathology associated with this HSV infection. We demonstrate that these observations result from the failure of both the innate and HSV-specific adaptive immune responses. At two days post-infection, NK cell numbers were significantly decreased in mice experiencing restraint stress. Studies examining the adaptive immune response revealed a decrease in the number of HSV-specific CD8 + T cells in not only the vaginal tissue itself but also the draining iliac lymph nodes (ILN). Furthermore, the number of functional cells, in terms of both their degranulation and interferon-γ production, in the ILN of stressed mice was decreased as compared to non-stressed mice. We conclude that psychological stress, through its suppression of both innate and adaptive immune responses, may be an important factor in the ability to control vaginal HSV infection.

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Section: Introductionmentioning

confidence: 99%

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Ashcraft¹,

Bonneau²

2008

Brain, Behavior, and Immunity

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“…It is the use of a harness specifically in trained animals to maintain them (rostro-caudal position) on the treadmill. As untrained animals did not need harnesses, we cannot exclude the possibility that harnesses were somehow associated, as other types of contention devices, 24 to some stress-related weight loss in the trained TT mice.…”

mentioning

confidence: 99%

Non-assisted treadmill training does not improve motor recovery and body composition in spinal cord-transected mice

et al. 2010

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Study design: Experiments in a mouse model of complete paraplegia. Objectives: To evaluate the effect of non-assisted treadmill training on motor recovery and body composition in completely spinal cord-transected mice. Settings: Laval University Medical Center, Neuroscience Unit, Quebec City, Quebec, Canada. Methods: Following a complete low-thoracic (Th9/10) spinal transection (Tx), mice were divided into two groups that were either untrained or trained with no assistance. Training consisted of placing the mice during 15 min with no further intervention (that is no tail pinching or body weight support) on a motorized treadmill (8-10 cm s À1 ) five times per week for 5 weeks. Locomotor performances were assessed weekly in both groups using two complementary locomotor rating scales. After 5 weeks, all mice were killed and adipose tissue, soleus, and extensor digitorum longus muscles were dissected for analyses. Results: No significant difference in locomotor performances or in muscle fibre type conversion was found between trained and untrained mice. In contrast, body weight, adipose tissue, whole muscle, and individual fibre cross-sectional area (CSA) values were significantly lower in trained compared with untrained animals. Conclusions: Non-assisted treadmill training in these conditions did not improve motor performances and contributed to further accentuate body composition changes post-Tx, suggesting that assistance provided manually, robotically, or pharmacologically may be key to spinal learning and recovery of locomotor function and body composition.

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“…Moreover, corticosterone modulates the expression of IgA and pIgR under conditions of stress (Jarillo-Luna et al 2007;Reyna-Garfias et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Campos-Rodrı́guez

Godínez‐Victoria

Reyna-Garfias

et al. 2016

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Effect of repeated restraint stress on the levels of intestinal IgA in mice

Cited by 68 publications

References 90 publications

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Non-assisted treadmill training does not improve motor recovery and body composition in spinal cord-transected mice

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

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