Effect of Repetitive Imaging on Topographic Measurements of the Optic Nerve Head

Weinreb, Robert N.; Lusky, Moshe; Bartsch, Dirk-Uwe; Morsman, David

doi:10.1001/archopht.1993.01090050070031

Cited by 183 publications

(85 citation statements)

References 12 publications

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“…In addition, the use of mean images appeared to be better than single images, in agreement with an earlier report by Weinreb et al 30 So far, few studies have reported on the possible value of SLO optic disc biometry for glaucoma follow-up. One possible technique for follow-up, the Topographic Change Analysis 20 was used by Chauhan et al 21 in a 5-year longitudinal follow-up study.…”

Section: Discussionsupporting

confidence: 90%

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Tangelder

Reus

Lemij

2005

Eye

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Purpose First, to determine the absolute measurement precision of scanning laser ophthalmoscopy (SLO) parameters, by expressing them as 95% limits of agreement (LA 95% ). Second, to propose a method for mathematically estimating the clinical ability of a parameter to monitor disease progression, expressed as the Discriminating Capacity Index (DCI). Methods We measured the optic disc of 14 healthy volunteers and 14 glaucoma patients. LA 95% -values were calculated from the average standard deviation of three measurements on the same day for repeatability, and three measurements on separate days within a 6-week period for reproducibility. We then calculated the DCI by dividing the measurement range by its LA 95% in healthy subjects and glaucoma patients separately. Thus, the DCI takes into account both the dynamic range of disease progression and the extent of measurement variance, providing an index of the possible clinical usefulness of a parameter. As the DCI is dimensionless it allows comparison across various parameters and across technologies.

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Section: Discussionsupporting

confidence: 90%

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Tangelder

Reus

Lemij

2005

Eye

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“…This is in contrast to the standard protocol of 3 images recommended usually. 45 However, because of the principal of regression to the mean, limiting the number of acquired topographic images to one image per eye is Eye not expected to alter the results in a screening procedure such as the one described here. 46 During the imaging procedure, the subjects fixated on a distant target with the fellow (non-test) eye.…”

Section: Ocular Perfusion Measurementsmentioning

confidence: 96%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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Purpose To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. Methods Twenty-two newly diagnosed and previously untreated POAG patients (mean age7SD: 68.38711.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. Results Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (Po0.0001) and increase in MOPP (Po0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P ¼ 0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P ¼ 0.0170; P ¼ 0.0260, and P ¼ 0.0170; P ¼ 0.0240 respectively).Conclusion Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.

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“…However, the ImageNet system was quite poor in confirming no change in control sets and correlated poorly with clinical judgment. Perhaps other approaches, such as the use of several images taken at the same time, could reduce the variability of the measurements and improve the utility of this technique to detect changes (Weinreb et al 1993;Burgoyne et al 1995). The results of this study may be specific to the Topcon ImageNet and cannot be generalized.…”

Section: Discussionmentioning

confidence: 98%

“…Qualitative or semiquantitative estimates of the optic nerve head by disc drawings or fundus photography (Lichter 1976;Klein et al 1985Klein et al , 1987Tielsch et al 1988;Varma et al , 1992Odberg & Rise 1985;Abrams et al 1994;Coleman et al 1996) and computerized quantitative techniques (Varma et al 1988;Dandona et al 1989;Dreher et al 1991;Burk et al 1993;Cioffi et al 1993;Weinreb et al 1993;Mikelberg et al 1993;Hoskins et al 1994;Varma et al 1994;Tezel et al 1996) can be used to record the appearance of the optic nerve head. Computerized disc analysis and laser scanning devices seem attractive but are expensive and their clinical utility has not been established yet in longitudinal studies.…”

mentioning

confidence: 99%

Detection of changes of the optic disc in glaucomatous eyes: Clinical examination and image analysis with the Topcon Imagenet system

Azuara‐Blanco

Katz

Spaeth

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: This study was designed to evaluate the clinical agreement in the detection of optic disc changes and the ability of computerized image analysis to detect glaucomatous deterioration of the optic disc. Methods: Pairs of stereophotographs of 35 glaucomatous optic discs taken 5 years apart and of 5 glaucomatous discs photographed twice on the same day. Two glaucoma specialists examined the pairs of stereophotographs (35 cases and 5 controls) in a masked manner and judged whether the optic disc showed changes in the optic disc compatible with progression of glaucomatous damage. The stereophotographs of the five optic discs photographed twice on the same day (which by definition did not change) and of five cases judged to have deteriorated by both glaucoma specialists were analyzed by computerized image analysis with the Topcon ImageNet system. Intra-and inter-observer agreement in the detection of optic disc changes (evaluated using kappa statistic), and changes in the rim area to disc area ratio (evaluated using descriptive statistics and paired t-test). Results: Intra-observer agreement had a kappa value of 0.75 for observer 1 and 0.60 for the observer 2. Inter-observer agreement between the glaucoma specialists had a kappa value of 0.60. The image analyzer did not discriminate between controls and cases with clinically apparent glaucomatous change of the optic disc. Conclusion: Clinical agreement in detecting changes in the optic disc was moderate to substantial. Computerized image analysis with the Topcon ImageNet system appeared not to be useful in detecting glaucomatous changes of the optic disc.

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Effect of Repetitive Imaging on Topographic Measurements of the Optic Nerve Head

Cited by 183 publications

References 12 publications

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Detection of changes of the optic disc in glaucomatous eyes: Clinical examination and image analysis with the Topcon Imagenet system

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