Effect of Repetitive Transcranial Magnetic Stimulation on Serum Levels of Steroid Adrenal Hormones in Parkinson’s Disease: Sex Differences

Афтанас, Л. И.; Zhanaeva, S. Ya.; Альперина, Е. Л.; Идова, Г. В.; Gevorgyan, M. M.; Дземидович, С С; Куликова, К И

doi:10.1007/s10517-022-05542-y

Cited by 4 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…therapy technique, where an electric current passes through a magnetic coil to generate a pulsed magnetic field that affects the brain, affecting neural electrical activity in the brain and altering cortical cell excitability. [3] In recent years, it has gradually been widely used in the treatment of neurological and psychiatric diseases. [3,4] Studies have shown that rTMS not only has a significant impact on symptoms of depression and anxiety in treatment resistant depression (TRD), but also in non-TRD patients with MDD.…”

Section: Our Study Was Approved By the Ethics Review Board Of Lianyun...mentioning

confidence: 99%

“…[3] In recent years, it has gradually been widely used in the treatment of neurological and psychiatric diseases. [3,4] Studies have shown that rTMS not only has a significant impact on symptoms of depression and anxiety in treatment resistant depression (TRD), but also in non-TRD patients with MDD. [5,6] A recent study found that treatment regimens combining high pulse doses and multiple daily treatments of rTMS showed improved efficacy for MDD.…”

Section: Our Study Was Approved By the Ethics Review Board Of Lianyun...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Although there are many antidepressants, not all patients respond to antidepressants, so further exploration of effective treatment plans is needed. [ 2 , 3 ] Repetitive transcranial magnetic stimulation (rTMS) is a commonly used physical therapy technique, where an electric current passes through a magnetic coil to generate a pulsed magnetic field that affects the brain, affecting neural electrical activity in the brain and altering cortical cell excitability. [ 3 ] In recent years, it has gradually been widely used in the treatment of neurological and psychiatric diseases.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3 ] In recent years, it has gradually been widely used in the treatment of neurological and psychiatric diseases. [ 3 , 4 ]…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Wang,

Fan,

Zhang

et al. 2023

Medicine

View full text Add to dashboard Cite

Background: Studies have reported the use of repetitive transcranial magnetic stimulation (rTMS) in patients with major depressive disorder (MDD). However, most studies focus on antidepressant effect of rTMS, but few on cognitive aspects. The present study aimed to explore the effect of rTMS on BDNF levels and cognitive function in the treatment of middle-aged and elderly MDD. Methods: This was a randomized controlled trial. A total of 120 elderly patients with MDD treated in The Second Affiliated Hospital of Xi’an Medical University from January 2021 to January 2023 were selected as research subjects. The patients were randomly divided into control group (n = 60, patients received simple oral treatment with escitalopram and sham rTMS) and study group (n = 60, patients received oral treatment with escitalopram combined with rTMS) according to the random number table method. We compared the clinical efficacy, serum BDNF levels, and cognitive function between the 2 groups. Results: After treatment, the HAMD-17 score in the study group was lower than that in the control group [13.00 (12.00–16.00) vs 17.00 (15.00–19.00), P < .05], and the RBANS score was higher than that in the control group [166.00 (161.25–171.75) vs 133.00 (130.00–136.75), P < .05]. The total effective rate of the research group was 95.0%, which was higher than the 82.0% of the control group (P < .05). The serum BDNF levels [36.00 (33.00–38.00) vs 30.00 (28.00–32.00), P < .05] and MoCA scores [24.00 (22.00–26.75) vs 23.00 (21.00–25.00), P < .05] of the study group were higher than those of the control group. There were no significant adverse reactions during the treatment of both groups. Conclusions: Compared with oral escitalopram alone, repeated transcranial magnetic stimulation in the treatment of middle-aged and elderly patients with major depressive disorder can further improve the efficacy, and can more effectively improve the BDNF level and cognitive function, with ideal safety.

show abstract

Section: Our Study Was Approved By the Ethics Review Board Of Lianyun...mentioning

confidence: 99%

Section: Our Study Was Approved By the Ethics Review Board Of Lianyun...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[ 3 ] In recent years, it has gradually been widely used in the treatment of neurological and psychiatric diseases. [ 3 , 4 ]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Wang,

Fan,

Zhang

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter

Lefaucheur,

Moro,

Shirota

et al. 2024

Clinical Neurophysiology

View full text Add to dashboard Cite

Motor function improvement and acceptability of non-invasive brain stimulation in patients with Parkinson's disease: a Bayesian network analysis

Qiu¹,

Yin²,

Wang³

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

BackgroundParkinson's disease (PD) is a neurodegenerative disorder defined by progressive motor and non-motor symptoms. Currently, the pro-cognitive effects of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are well-supported in previous literatures. However, controversy surrounding the optimal therapeutic target for motor symptom improvement remains.ObjectiveThis network meta-analysis (NMA) was conducted to comprehensively evaluate the optimal strategy to use rTMS and tDCS to improve motor symptoms in PD.MethodsWe searched PubMed, Embase, and Cochrane electronic databases for eligible randomized controlled studies (RCTs). The primary outcome was the changes of Unified Parkinson's Disease Rating Scale (UPDRS) part III score, the secondary outcomes were Time Up and Go Test (TUGT) time, and Freezing of Gait Questionnaire (FOGQ) score. The safety outcome was indicated by device-related adverse events (AEs).ResultWe enrolled 28 studies that investigated various strategies, including high-frequency rTMS (HFrTMS), low-frequency rTMS (LFrTMS), anodal tDCS (AtDCS), AtDCS_ cathode tDCS (CtDCS), HFrTMS_LFrTMS, and Sham control groups. Both HFrTMS (short-term: mean difference (MD) −5.21, 95% credible interval (CrI) −9.26 to −1.23, long-term: MD −4.74, 95% CrI −6.45 to −3.05), and LFrTMS (long-term: MD −4.83, 95% CrI −6.42 to −3.26) were effective in improving UPDRS-III score compared with Sham stimulation. For TUGT time, HFrTMS (short-term: MD −2.04, 95% CrI −3.26 to −0.8, long-term: MD −2.66, 95% CrI −3.55 to −1.77), and AtDCS (short-term: MD −0.8, 95% CrI −1.26 to −0.34, long-term: MD −0.69, 95% CrI −1.31 to −0.08) produced a significant difference compared to Sham stimulation. However, no statistical difference was found in FOGQ score among the various groups. According to the surface under curve ranking area, HFrTMS ranked first in short-term UPDRS-III score (0.77), short-term (0.82), and long-term (0.84) TUGT time, and short-term FOGQ score (0.73). With respect to the safety outcomes, all strategies indicated few and self-limiting AEs.ConclusionHFrTMS may be the optimal non-invasive brain stimulation (NIBS) intervention to improve motor function in patients with PD while NIBS has generally been well tolerated. However, further studies focusing on the clinical outcomes resulting from the different combined schedules of tDCS and rTMS are required.Systematic review registrationhttps://inplasy.com/inplasy-2023-4-0087/, identifier: 202340087.

show abstract

Effect of Repetitive Transcranial Magnetic Stimulation on Serum Levels of Steroid Adrenal Hormones in Parkinson’s Disease: Sex Differences

Cited by 4 publications

References 14 publications

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter

Motor function improvement and acceptability of non-invasive brain stimulation in patients with Parkinson's disease: a Bayesian network analysis

Contact Info

Product

Resources

About