Effect of resistance exercise (body building) training on serum leptin levels in young men. Implications for relationship between body mass index and serum leptin

Gippini, Antonio; Mato, A.; Peinó, R.; Lage, Mary; Diéguez, Carlos; Casanueva, Felipe F.

doi:10.1007/bf03343653

Cited by 36 publications

(8 citation statements)

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“…Weight (r 2 ϭ 0.11; P ϭ 0.17) and BMI (r 2 ϭ 0.03; P ϭ 0.50) also failed to correlate with leptin in Ache males, contrasting with Western populations where leptin seems to be associated with adiposity in even the leanest men (Hickey et al, 1996). Indeed, clinical studies with comparable sample sizes of lean men have commonly reported a significant association between body composition and leptin (Elias et al, 2000;Gippini et al, 1999;Leal-Cerro et al, 1998;Rosenbaum et al, 1997). Sexually dimorphic leptin concentrations have been reported to persist in older men and postmenopausal women (Rosenbaum et al, 1996).…”

Section: Resultsmentioning

confidence: 96%

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Bribiescas

2001

American J Phys Anthropol

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Leptin is a recently discovered peptide hormone secreted primarily from adipocytes in humans and other mammals; it is a reflection of fat stores, and has been associated with reproductive function. However, few leptin measurements are available from nonindustrialized populations, including contemporary hunter/gatherer communities undergoing the transition to sedentary agriculture. This investigation reports single-sample serum leptin measurements in healthy Ache Amerindian males (n = 21; average age, 32.8 +/- 3.4 SE) and females (n = 12; average age, 31.3 +/- 4.3) in eastern Paraguay. Ache leptin concentrations were much lower than in industrialized populations, although significant sexual dimorphism was evident (female 5.64 ng/ml +/- 0.91 SE vs. male 1.13 ng/ml +/- 0.08; P < 0.0001). Indeed, female leptin levels were similar to those of anorexic women, despite apparently adequate adiposity. Controlling for fat percentage, no significant sex difference was evident, suggesting that adiposity was the primary source of leptin variation. Body fat percentage was highly correlated with leptin in females (r2 = 0.72; P < 0.0005) but not males, who exhibited a modest negative correlation (r2 = 0.25; P < 0.03). Weight (r2 = 0.45; P = 0.02) and BMI (kg/m2) (r2 = 0.81; P < 0.0001) were also significantly correlated in females but not males. These results suggest that: 1) clinical leptin norms based on industrialized populations may represent the highest range of human variation and may not be representative of most human populations; 2) hormonal priming may underlie population variation in leptin profiles; and 3) the relative importance of leptin as a proximate mechanism regulating reproductive effort during human evolution may have been modest.

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Section: Resultsmentioning

confidence: 96%

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Bribiescas

2001

American J Phys Anthropol

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“…BMI is accepted internationally as a useful measure of body fat content although muscular subjects may have a high BMI despite a low fat mass. 37 BMI requires a mathematical calculation and knowledge of acceptable ranges. Waist circumference is less influenced by muscular mass and reflects visceral fat but requires knowledge of acceptable ranges that differ between men and women.…”

Section: Discussionmentioning

confidence: 99%

Association of central obesity with early Carotid intima-media thickening is independent of that from other risk factors

et al. 2008

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Aim:We investigated whether anthropometric measurements or metabolic risk factors correlated more with vascular changes associated with obesity. Methods: One hundred never smoking subjects (71 women, 29 men) without vascular events, with blood pressure (BP) o140/ 90 mm Hg, LDL cholesterol o4 mmol/l, glucose o6.2 mmol/l participated. Anthropometric measurements (body mass index (BMI), waist/hip ratio (WHR), waist circumference (WC) and Waist/height ratio WHTR) and metabolic risk factors (glucose, insulin, lipid and uric acid levels plus BP) were assessed. Subjects underwent vascular measurements (Carotid intima-media thickness (IMT) using duplex ultrasonography, vascular stiffness assessment (Augmentation Index) by applanation tonometry and brachial artery reactivity tests). Results: Risk factors were in the 'normal distribution'. BMI, WHR, WC, WHTR correlated significantly with triglyceride, HDL, LDL, insulin, glucose, uric acid and systolic BP levels (Po0.001). IMT correlated with WHTR, BMI, WC, Glucose (Po0.001), Homoeostasis Model Assessment (HOMA) and cholesterol levels (Po0.05). Only Age, WHTR or BMI were significant correlates of IMT in a multivariate analysis (Po0.01) including WHTR or BMI, with age, sex, systolic BP, HDLc and HOMA. Augmentation Index correlated with age (Po0.0001), WHTR and WC (Po0.0005) but with age only in a multivariate analysis. Brachial reactivity did not correlate with any anthropometric or metabolic parameters. Anthropometric cutoff points, (BMI X25, WC X102 cm men, X88 cm women, WHR X0.9 men, X0.8 women and WHTR X0.5 men and women) significantly differentiated normal from abnormal metabolic and vascular measurements. The WHTR ratio X0.5 was as reliable as the BMI cutoff X25 in determining metabolic and vascular abnormalities. BMI and WHTR were strongly associated with 89% agreement (Po0.0001). Conclusion: These results demonstrated that in 'healthy individuals', anthropometric parameters and metabolic risk factors correlated with each other, but anthropometric parameters were the only significant correlates of carotid IMT. A waist/height ratio X0.5 predicts both early vascular and metabolic changes. These data support a risk factor independent vasculotrophic effect of obesity.

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“…Different types of measurements have their own advantages and disadvantages. Muscular subjects may have a high BMI despite a low fat mass [14], and BMI requires a more complicated mathematical calculation, as well as knowledge of acceptable ranges. Although WC is easily measured using a cheap nonelastic tape, it is more easily understood as a concept of obesity than other anthropometric ratios.…”

Section: Discussionmentioning

confidence: 99%

Association of Anthropometric Measurements with Components of Metabolic Syndrome and Carotid Intima-Media Thickness in Young Healthy Taiwanese

Tan

Chuang

2012

Journal of Medical Ultrasound

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KEY WORDSbody mass index, intima-media thickness, metabolic syndrome, waist circumference, waist circumferenceto-height ratioBackground: The degree of vascular changes and obesity-related metabolic abnormalities may differ from the distribution of body fat. We investigated the association of anthropometric measurements with vascular changes and components of metabolic syndrome (Mets). Materials and methods: One hundred and eleven volunteers (48 women, 63 men) were recruited. Anthropometric measurements included body mass index (BMI), waist circumference (WC), waist-to-hip circumference ratio (WHR), and waist circumference-to-height ratio (WHeiR). The carotid intima-media thickness (IMT) was measured by using B-mode ultrasonography. Correlations between anthropometric measures, components of Mets, and carotid IMT were analyzed. Results: All anthropometric measurements significantly correlated with components of Mets. Carotid IMT correlated with sex, age, blood pressure, body weight, BMI, WC, hip circumference (HC), WHR, WHeiR, fasting plasma glucose, and lipid profile. BMI (r Z 0.455) showed the strongest correlation followed by WC (r Z 0.405), WHeiR (r Z 0.405) and WHR (r Z 0.365) with carotid IMT. Only age, sex, and BMI were significant correlates of IMT in multivariate linear analysis. Conclusion: General adiposity as measured by BMI, rather than abdominal fat, is significantly correlated with carotid IMT in healthy young Taiwanese individuals. ª

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Effect of resistance exercise (body building) training on serum leptin levels in young men. Implications for relationship between body mass index and serum leptin

Cited by 36 publications

References 35 publications

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Serum leptin levels and anthropometric correlates in Ache Amerindians of eastern Paraguay

Association of central obesity with early Carotid intima-media thickening is independent of that from other risk factors

Association of Anthropometric Measurements with Components of Metabolic Syndrome and Carotid Intima-Media Thickness in Young Healthy Taiwanese

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