Effect of resistin on granulosa and theca cell function in cattle

Spicer, L. J.; Schreiber, Nicole B.; Lagaly, Dana V.; Aad, Pauline Y.; Douthit, Laura B.; Grado-Ahuir, Juan Alberto

doi:10.1016/j.anireprosci.2011.01.005

Cited by 62 publications

(39 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3). Spicer and coworkers demonstrated that 30 ng/mL of resistin weakly stimulated FSH plus IGF1-induced E2 production, but had no effect on IGF1-or insulin-induced P4 and A4 production by theca cells or P4 production by granulosa cells of LFs (Spicer et al 2011). However, in granulosa cells from SFs, resistin attenuated the stimulatory effect of IGF1 on P4 and E2 secretion.…”

Section: Adiponectin and Resistin In Vitro Effects On Ovarian Steroidmentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

View full text Add to dashboard Cite

Adipokines, including adiponectin and resistin, are cytokines produced mainly by the adipose tissue. They play a significant role in metabolic functions that regulate the insulin sensitivity and inflammation. Alterations in adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissues, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species. Thus, these adipokines could be metabolic signals that partially explain infertility related to obesity, such as polycystic ovary syndrome (PCOS). Species and gender differences in plasma levels, tissue or cell distribution and hormonal regulation have been reported for resistin and adiponectin. Furthermore, until now, it has been unclear whether adiponectin and resistin act directly or indirectly on the hypothalamo-pituitary-gonadal axis. The objective of this review was to summarise the latest findings and particularly the species and gender differences of adiponectin and resistin on female and male reproduction known to date, based on the hypothalamo-pituitary-gonadal axis.Reproduction (2017) 153 R215-R226

show abstract

Section: Adiponectin and Resistin In Vitro Effects On Ovarian Steroidmentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

View full text Add to dashboard Cite

show abstract

“…In a very recent study, Sanchez-Solana et al (2012) identified mouse resistin as a ligand for the tyrosine kinase-like orphan receptor (ROR1) to regulate SOCS-3, glucose transporter 4 (GLUT4), and GLUT1 expression and to modulate glucose uptake and promote adipogenesis of 3T3-L1 cells, which thus opens a new line of research to explain the underlying mechanisms of resistin action in adipogenesis and the development of IR. In addition to its expression in adipose tissue and macrophages, resistin mRNA was also found in hypothalamo-pituitary axis, rat testis, and rat and bovine ovaries (Maillard et al 2011), and resistin has been suggested to affect bovine and rat granulose cell steroidogenesis and proliferation (Maillard et al 2011, Spicer et al 2011.…”

Section: Resistinmentioning

confidence: 99%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

show abstract

“…Furthermore, human recombinant resistin decreases basal but not IGF-I-induced progesterone and oestradiol production by the bovine granulosa cells (Maillard et al, 2011). Spicer et al (2011), have also observed that resistin preferentially inhibited steroidogenesis in the granulosa cells from small follicles and inhibited proliferation of the granulosa cells from large follicles, suggesting that the ovarian response to resistin is altered during follicular development. The little data available suggest that resistin may be involved in the nutritional regulation of ovarian function and fertility in ruminants and on this basis is worthy of further investigation.…”

Section: Metabolic Hormonesmentioning

confidence: 84%

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

View full text Add to dashboard Cite

The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

show abstract

Effect of resistin on granulosa and theca cell function in cattle

Cited by 62 publications

References 54 publications

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Contact Info

Product

Resources

About