Effect of Restraint Stress on Lead‐Induced Male Reproductive Toxicity in Rats

Priya, P. Hari; Reddy, P. Sreenivasula

doi:10.1002/jez.1738

Cited by 50 publications

(30 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, many of the conditions which are known to have detrimental effects to male reproductive system are due to an induction of oxidative stress [89]. Besides altering hormonal changes, EDCs are also known to induce oxidative stress through a reduction of antioxidant enzyme (e.g., superoxide dismutase, dismutase, catalase and glutathione peroxidase) activities and/or an increase in lipid peroxidation [33,90-92]. In addition, EDC-induced oxidative stress was found to disrupt cell adhesion protein function between testicular cells through the phosphorylation of phosphoinositide 3-kinase/c-Src/focal adhesion kinase (PI3K/c-Src/FAK) signaling cascade [88].…”

Section: Impact Of Edcs On Induction Of Reaction Oxygen Speciesmentioning

confidence: 99%

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Wan

Mruk

Wong

et al. 2013

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

Introduction Exposure to endocrine disrupting chemicals (EDCs) has recently been linked to declining fertility in men in both developed and developing countries. Since many EDCs possess intrinsic estrogenic or androgenic activities, thus, the gonad is one of the major targets of EDCs. Areas covered For the past 2 decades, studies found in the literature regarding the disruptive effects of these EDCs on reproductive function in human males and also rodents were mostly focused on oxidative stress-induced germ cell apoptosis, disruption of steroidogenesis, abnormal sperm production and disruption of spermatogenesis in particular cell adhesion function and the blood–testis-barrier (BTB) function. Herein, we highlight recent findings in the field illustrating testis-specific proteins are also targets of EDCs. Expert opinion This information should be helpful in developing better therapeutic approach to manage ECD-induced reproductive toxicity. This information is also helpful to identify potential targets for male contraceptive development.

show abstract

Section: Impact Of Edcs On Induction Of Reaction Oxygen Speciesmentioning

confidence: 99%

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Wan

Mruk

Wong

et al. 2013

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

show abstract

“…Restraint stress is widely utilized to mimic the psychological stress in many studies, in which the individual is isolated from its group and his movement is confined to a restricted area 16 , 17 . Increasing evidence demonstrates that chronic stress, including restraint stress, results in a significant decline in the quality of semen 18 – 20 , which could be related to a disruption in testosterone secretion in testes 20 – 22 , and an increase of oxidative stress 20 , 23 , 24 , and apoptosis of germ cells 19 , 24 , 25 .…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress is one of the major factors that induce testicular cells apoptosis in testes 35 – 37 . Several studies showed that stress induced alterations in spermatogenesis potentially due to the increased oxidative stress in testes 20 , 23 , 24 . In addition, some other studies demonstrated that melatonin has an anti-apoptotic effect in somatic and germ cells 22 , 38 – 40 .…”

Section: Introductionmentioning

confidence: 99%

Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway

Guo

Sun

et al. 2017

Sci Rep

103

View full text Add to dashboard Cite

Decline in semen quality has become a global public health concern. Psychological stress is common in the current modern society and is associated with semen decline. Increasing evidence demonstrated that melatonin has anti-apoptotic and antioxidant functions. Whether melatonin can ameliorate the damage in testes induced by psychological stress has never been investigated. Here, a mouse model of restraint stress demonstrated that melatonin normalized the sperm density decline, testicular cells apoptosis, and testicular oxidative stress in stressed male mice. Melatonin decreased reactive oxygen species (ROS) level, increased superoxide dismutase (SOD) and glutathione (GSH) activities, and downregulated inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) activities in stressed mice testes. Furthermore, melatonin reduced the stress-induced activation of the NF-κB signaling pathway by decreasing the phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) and p65 nuclear translocation. In addition, melatonin upregulated the expression of anti-oxidant proteins including nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). Meanwhile, in vitro studies also demonstrated melatonin could reduce oxidative apoptosis of testicular cells. Collectively, melatonin mitigated psychological stress-induced spermatogenic damage, which provides evidence for melatonin as a therapy against sperm impairment associated with psychological stress.

show abstract

“…According to relevant reports, pachytene spermatocytes and early spermatids are the most sensitive testicular cells to thermal stress (Hari Priya & Reddy, ; Wallach, Kandeel, & Swerdloff, ). Additionally, it has been illustrated that HS can lead to testicular weight reduction, sperm dysfunction and sperm mortality increase (Ebeid, ; McDaniel, Hood, & Parker, ).…”

Section: Introductionmentioning

confidence: 99%

Royal jelly protects male rats from heat stress‐induced reproductive failure

et al. 2018

View full text Add to dashboard Cite

Royal jelly (RJ) as an antioxidant has been shown to have attenuated oxidative stress damages in reproductive organs. The objective was carried out the effects of RJ on sperm characteristics, sperm malondialdehyde (MDA) concentration and in vitro fertilisation (IVF) outcome in heat stress (HS) exposed male rats. Forty-eight male rats were randomly divided into eight groups; group 1 received normal saline, group 2 received RJ (100 mg kg −1 day −1 ; PO), groups 3, 4 and 5 were heat-stressed (43, 39 and 37°C for 20 min per day respectively) and groups 6, 7 and 8 were heat-stressed along with RJ (43, 39 and 37°C for 20 min per day, respectively, plus RJ at a dose of 100 mg kg −1 day −1 ; PO). The HS was induced through immersion of experimental rat scrotums in a water bath. After 48 days, the HS induced remarkable diminish in sperm motility, viability and fertilising potential along with reduced blastulation rate and enhanced sperm chromatin abnormality, MDA levels and DNA damage.Nevertheless, RJ co-administration improved sperm characteristics and early embryo development as well as sperm lipid peroxidation level. Our data suggest that RJ can effectively ameliorate the experimental HS-induced infertility in rats through MDA concentration restoration and sperm characteristics and pre-implantation embryo development improvement. K E Y W O R D Searly embryo development, heat stress, malondialdehyde, rat, royal jelly, sperm

show abstract

Effect of Restraint Stress on Lead‐Induced Male Reproductive Toxicity in Rats

Cited by 50 publications

References 61 publications

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals

Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway

Royal jelly protects male rats from heat stress‐induced reproductive failure

Contact Info

Product

Resources

About