Effect of resveratrol and pterostilbene on aging and longevity

Abstract

Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and highcalorie diets. Moreover, we also discuss the positive effect of Abbreviations: ABTS, 2,2 0 -Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; Akt, v-akt murine thymoma viral oncogene; AMPK, AMP-activated kinase; ARE, antioxidant response element; C. elegans, Caenorhabditis elegans; cAMP, cyclic adenosine monophosphate; CCL3, C-C motif chemokine ligand 3; CNS, central nervous system; CREB, cAMP response element binding protein; CRP, c-reactive protein; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; eNOS, endothelial nitric oxide synthase; ERK, extracellular-signal-regulated kinase; ER-a, estrogen receptor alpha; FOXO1, forkhead box protein O1; FOXO3, forkhead box O3A protein; GSH, glutathione; GSH-Px, glutathione peroxidase; GSK3b, glycogen synthase kinase 3 b; hTERT, human telomerase reverse transcriptase; HtrA2, HtrA serine peptidase 2; IDH2, dehydrogenase 2; IFN-c, interferon gamma; IL-18, interleukin-18; IL-1b, interleukin 1 b; IL-6, interleukin-6; LDL, low-density lipoprotein; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; MLC, myosin light chain; MMP-1, matrix metalloproteinase-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; MnSOD, manganese superoxide dismutase; mRNA, messenger RNA; mtROS, mitochondrial reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NALP-3, NACHT 5 LRR and PYD domainscontaining protein 3; NAMPT, nicotinamide phosphoribosyltransferase; NFAT, nuclear factor of activated T-cells; NF-rB, nuclear factor-jB; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; NS, Nutritional Supplement; OA, osteoarthritis; oxoLDL, oxidized low-density lipoprotein; PARK7, Parkinson disease protein 7; PARKIN, parkinson juvenile disease protein; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; PINK1, PTEN-induced putative kinase 1; PKB, protein kinase B; RhoA, Ras homolog gene family 5 member A; ROCK2, Rho-associated 5 coiled-coil containing protein kinase 2; ROS, reactive oxygen species; SAMP8, senescence accelerated mouse-prone 8; SCID, severe combined immunodeficiency; SHR, spontaneously hypertensive rat; SIRT1, sirtuin 1; SIRT4, sirtuin 4; SOD, superoxide peroxidase; STZ, streptozotocin; T2D, type 2 diabetes; TIMP-1, TIMP metallopeptidase inhibitor 1; TLR5, toll-like receptor 5; TNF-a, tumor necrosis factor alpha; UVB, ultraviol...

Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis

“…Beyond its effects on bone health, resveratrol has several positive effects on other aspects of health, such as aging in women, blood pressure, decreasing cardiometabolic disease risk, cognitive performance, and mental health . Hence, resveratrol is a cost‐effective supplement in health improvement, especially in adulthood.…”

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

“…The physiological activities of PTER include: antioxidant and anti-inflammatory activity, ability to restore intracellular calcium and cognitive function (Li Y. R. et al, 2018) (Figure 3).…”

“…PTER stands out for its antioxidant action against numerous types of free radicals: HO, H 2 O 2 (Castellani et al, 2008;Mikstacka et al, 2010;Acharya and Ghaskadbi, 2013) and NO • (Pan et al, 2008;Zhang et al, 2012). It is able to neutralize metal-induced radicals (Rossi et al, 2013;Saw et al, 2014) and to inhibit oxidation and lipoperoxidation processes (Rimando et al, 2002) causing a decrease in carbonylated proteins and oxidation by-products: MDA, HNE and 8-OHdG (Li Y. R. et al, 2018) (Figure 3). The administration of PTER improves the antioxidant defenses of the brain by raising the levels of CAT, GSH and the activity of SOD (Naik et al, 2017) (Figure 3).…”

“…Pre-treatment with PTER has a potent antioxidant function that increases SOD activity in hypoxicischemic brain injury in the P7 rat model (Li D. et al, 2016). Treatment with PTER reduces glutamate-induced OS injury by reducing ROS and increasing the function of SOD and GSH by activating the Nrf2 signaling pathway in neuronal cells (Wang et al, 2016), a target factor for the prevention of diseases related to aging such as neurodegenerative diseases (Bhakkiyalakshmi et al, 2016;Li Y. R. et al, 2018) (Figure 3).…”

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“…Resveratrol is a natural polyphenol with anticardiovascular, anticancer, antibacterial, anti-inflammatory, antiaging, antineurodegenerative, and other pharmacological effects [209]. Wu et al [210] used different doses (30 and 100 mg/kg/day) of resveratrol to intervene in mice with premature ovarian aging caused by chemotherapy.…”