Effect of Resveratrol Content in Red Wine on Circulating Sex Hormone‐Binding Globulin: Lessons from a Pilot Clinical Trial

Abstract

Scope: Low sex hormone-binding globulin (SHBG) levels are associated with higher risk of developing cardiovascular disease. Epidemiological studies have shown that red wine has beneficial effects on cardiovascular disease. In this work if resveratrol content in red wine increases SHBG levels is explored. Methods and results: A pilot study aims at testing the effect of drinking for 14 days two types of red wine with different resveratrol content is conducted in 26 healthy volunteers. SHBG levels and several biochemical parameters are measured at the beginning and the end of every period. Results show that consumption of both wines does not change body mass index or biochemical markers of liver injury. The low resveratrol wine does not modify the lipid profile or SHBG levels. By contrast, red wine with high resveratrol content significantly reduces total cholesterol in both men and women. Finally, red wine with high resveratrol content increases circulating SHBG in women but not in men. Conclusions: Red wine rich in resveratrol reduces total cholesterol in men and women and increases SHBG only in women. Further research aims at investigating the potential SHBG role enhancement mediated by resveratrol regarding cardiovascular protection that presents women in comparison with men seems warranted.

Resveratrol and Wine: An Overview of Thirty Years in the Digital News

“…Consequently, this cannot be considered as a negative effect of resveratrol intake. In any case, other authors did find a decrease in serum total cholesterol values [ 46 ] or a small increase [ 47 ] after nutritional interventions, even in healthy subjects, but it should be emphasized that the data, before and after resveratrol intervention, remained always within a range accepted as physiologic (200–220 mg/dL).…”

Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate

“…Notably, moderate RW consumption did not alter the plasma mediators of inflammation in patients with T2DM [92]. No significant differences in fasting plasma glucose levels were revealed in a 14-day pilot study that compared two types of RW with different resveratrol contents [98]. Thus, no fasting glycaemic changes were detected in CAD [100] and hypercholesterolaemic [27] patients after ingesting RW.…”

“…Accordingly, moderate wine consumption did not promote weight gain or abdominal adiposity in controlled diabetic patients following the Mediterranean diet [84], nor did fat accumulate in subcutaneous and abdominal fat depots in healthy subjects with a waist circumference above 94 cm [38]. A study that focused on two types of RW with different resveratrol content showed that the consumption of neither RW changed BMI [98]. Interestingly, healthy subjects consuming RW for 14 days displayed increased plasma levels of leptin, the main adipokine with the primary function of regulating energy balance, while no significant increase in plasma levels of adiponectin and other adipocytokines was observed [95].…”

“…A study investigating the potential contribution of ET components in inducing beneficial effects on the lipid profile level demonstrated that RW consumption for four weeks induced an improvement in HDL and fibrinogen plasma levels compared with control groups drinking water, with or without red grape extract [30]. In a recent study by Briansó-Llort and colleagues, RW rich in resveratrol had positive effects on total cholesterol, in healthy volunteers [98].…”

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

“…Evidence for a beneficial effect of increased SHGB in BC is also based on findings showing that SHGB reverses the anti-apoptotic effect of estradiol in BC cells, with a binding site on BC cells that has been shown to inhibit estradiol-induced cell proliferation after SHGB binding [224]. Indeed, other clinical studies have confirmed the modulatory effect of resveratrol on SHGB expression [225].…”