Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

Bujanda, Luís; García-Barcina, María; Juan, Virginia Gutiérrez‐de; Bidaurrazaga, J.; Luco, Marian Fernández de; Gutiérrez-Stampa, Marian; Larzábal, Mikel; Hijona, Elisabeth; Sarasqueta, Cristina; Echenique-Elizondo, Miguel; Arenas, Juan

doi:10.1186/1471-230x-6-35

Cited by 54 publications

(31 citation statements)

References 35 publications

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“…Uphadhay et al have showed that resveratrol not only modulates liver toxicity markers but also alters many forms of phase I and phase II xenobiotic metabolizing enzymes both at the level of transcription (mRNA level), as well as at the level of catalytic activity (35). Bujanda et al have also mentioned that resveratrol reduces mortality and liver damage produced by alcohol in mice (36).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Protects Against Methotrexate-Induced Hepatic Injury in Rats

Tunalı-Akbay¹,

Şehirli²,

Ercan³

et al. 2010

J Pharm Pharm Sci

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-Purpose. The aim of this study was to investigate the possible protective effect of resveratrol on some liver and blood parameters in methotrexate (MTX) induced toxicity in rats. MTX is used widely to treat various neoplastic diseases such as acute lymphoblastic leukemia, lymphoma, solid cancers, and autoimmune diseases. We hypothesized that resveratrol has a potential to decrease the oxidant damage in MTX-induced hepatic injury. Methods. Following a single dose of methotrexate (20 mg/kg, i.p.), either saline or resveratrol (10 mg/kg, orally) was administered for 5 days. After decapitation of the rats, trunk blood was obtained and the liver was removed to measure malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) and tissue factor (TF) activities and collagen content. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity were measured in the serum samples, while TNF-α and total antioxidant capacity were assayed in plasma samples. Results. Our results showed that MTX administration increased the hepatic MDA levels, MPO and TF activities and collagen contents and decreased GSH, while these alterations were reversed in resveratroltreated group. Elevated AST and ALT activities ALT and TNF-α level observed following MTX treatment was depressed with resveratrol. . Conclusions. The present study showed that resveratrol protects against MTX-induced hepatic injury and may be of therapeutic potential in alleviating the systemic side effects of this chemotherapeutic agent. _______________________________________________________________________________________

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Section: Discussionmentioning

confidence: 99%

Resveratrol Protects Against Methotrexate-Induced Hepatic Injury in Rats

Tunalı-Akbay¹,

Şehirli²,

Ercan³

et al. 2010

J Pharm Pharm Sci

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“…RV, a natural antioxidant, has been suggested to reduce DNA damage and oxidative organ injury (5). Several studies demonstrated the hepatoprotective effects of RV in vivo (6,7). RV (10 mg/ kg body weight (bw)) pretreatment was found to suppress the lipid peroxidation in the kidneys of ferric nitrilotriacetate-treated rats (5).…”

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confidence: 99%

Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Aydın¹,

Şahin²,

Bacanlı³

et al. 2016

Balkan Med J

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Background:The increases of free radicals have been proposed to be involved in the pathogenesis of sepsis, which leads to multiple-organ dysfunction syndromes. The uses of antioxidants as a complementary tool in the medical care of oxidative stress-related diseases have attracted attention of researchers. Resveratrol (RV) has suggested being antioxidant, anti-proliferative, and anti-inflammatory effects in various experimental models and clinical settings. Aims: This study was undertaken to evaluate the protective effects of RV on oxidative DNA damage induced by sepsis in the liver and kidney tissues of Wistar albino rats. Study Design: Animal experimentation. Methods: Four experimental groups consisting of eight animals for each was created using a total of thirty-two male Wistar albino rats. Sham group was given 0.5 mL of saline intra-peritoneal (ip) only following laparatomy. Sepsis group was given 0.5 mL saline ip only following the induction of sepsis. RV-treated group was given a dose of 100 mg/kg ip RV in 0.5 mL saline following laparatomy. RVtreated sepsis group was given 100 mg/kg ip RV in 0.5 mL saline following the induction of sepsis. A model of sepsis was created by cecal ligation and puncture technique. In the liver and kidney tissues, oxidative stress parameters (malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPX)) and a proinflammatory cytokine (tumor necrosis factor alpha (TNF-alpha)), were evaluated spectrophotometrically and DNA damage was determined by the alkaline single cell gel electrophoresis (comet assay) technique using formamidopyrimidine DNA glycosylase protein. Results:In the RV-treated sepsis group, the levels of MDA and TNF-alpha were lower and GSH levels, SOD and GPX activities were higher than in the septic rats (p<0.05). RV treatment significantly reduced the sepsis-induced oxidative DNA damage in the liver and kidney cells (p<0.05). Conclusion: It is suggested that RV treatment might reduce the sepsis-induced oxidative DNA damages in sepsis-related diseases; however, there is a need for more studies to clear up the protective mechanisms of RV against sepsis.

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“…Resveratrol up-regulated anti-oxidant enzyme activities in rat brain (Mokni et al, 2007a), heart (Mokni et al, 2007b) and kidney (Chander et al, 2005). Resveratrol also efficiently protected against endotoxemia-induced acute phase response in rats (Sebai et al, 2009), protected the liver and the heart from oxidative stress induced by LPS (Sebai et al, 2010;Sebai et al, 2011), or acetaminophen (Sener et al, 2006), cadmium (Eybl et al, 2006), alcohol (Bujanda et al, 2006), CCl4 (Rivera et al, 2008), naphthalene (Sehirli et al, 2008), pyrogallol (Upadhyay et al, 2008) and ischemia/reperfusion injury (HassanKhabbar et al, 2008). In addition resveratrol has been shown to alleviate alcoholic fatty liver in mice (Ajmo et al, 2008) and more recently to exert protective effects on calcium-induced oxidative stress in rat heart mitochondria (Gutiérrez-Pérez et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of grape seed and skin extract on high dosage garlic-induced renal oxidative stress

Hamlaoui

Samti

Mokni

et al. 2012

Bangladesh J Pharmacol

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Protective effect of grape seed and Protective effect of grape seed and Protective effect of grape seed and skin extract on high dosage garlic skin extract on high dosage garlic skin extract on high dosage garlic---induced renal oxidative stress induced renal oxidative stress induced renal oxidative stress BJP IntroductionGarlic (Allium sativum L.) has been widely used in traditional medicine and its health effects are mainly attributable to organosulfur compounds (Berginc et al., 2010) and to flavonoids and phenolics (Shirzad et al., 2011). However, some controversies persist concerning garlic dose and mode of administration. In a prior study, we showed that a high garlic dose administered intraperitoneally (ip) induced a pro-oxidant effect and ultimately blood toxicity (Hamlaoui-Gasmi et al., 2011a).Grape seed and skin extract (GSSE) is a nutritional supplement exhibiting beneficial health effects (Suwannaphet et al., 2010) and containing polyphenolics classified as flavonoid and non-flavonoid compounds (Khanal et al., 2009). Flavonoids, which are highly concentrated in seeds, are mainly composed of monomeric catechins, proanthocyanidins, and flavonols such as quercetin (Renaud and De Lorgeril, 1992). Nonflavonoids, highly abundant in skin, contain stilbenes such as resveratrol, which is at the basis of the French Paradox (Renaud and De Lorgeril, 1992). GSSE has wide ranging benefits as cardioprotective (Decordé et al., 2009) and neuroprotective effects (Wang et al., 2009). More specifically, resveratrol is multi-organ protective owing to its anti-oxidant (Kelen and Tepe, 2007) and anti-inflammatory properties (Kowalczyk et al., 2010). Proanthocyanidins exert antineoplasic effects by inducing cytotoxicity towards some cancer cells (Chatelain et al., 2011). Quercetin and rutin are neuroprotective (Jimenez-Aliaga et al., 2011), and catechin, epicatechin, and gallic acid exhibited cholesterol-lowering activity (Ngamukote et al., 2011). AbstractIn this study, the protective role of grape seed and skin extract (GSSE) against high garlic dose-induced renal toxicity has been evaluated. Rats were intraperitoneally injected with garlic (5 g/kg bw) or GSSE (500 mg/kg bw) or a combination of garlic and GSSE at the same doses daily for one month. Renal oxidative stress markers and anti-oxidant status were evaluated. We also measured plasma creatinine and urea. Data showed that high garlic dose induced renal toxicity by increasing creatinine and urea and a pro-oxidative status characterized by increased malondialdehyde, carbonyl protein, calcium and H2O2, but decreased free iron. Unexpectedly garlic increased catalase but decreased peroxidase and superoxide dismutase activities. GSSE co-treatment counteracted almost all garlic-induced deleterious effects. In conclusion, high garlic dose induced a pro-oxidative state characterized by the Fenton reaction between H2O2 and free iron, inducing Ca 2+ depletion, while GSSE exerted anti -oxidant properties and Ca 2+ repletion. Article Info

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Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

Abstract: Background: Resveratrol is a polyphenol with important antiinflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol-induced mortality and liver lesions in mice.

Cited by 54 publications

References 35 publications

Resveratrol Protects Against Methotrexate-Induced Hepatic Injury in Rats

Resveratrol Protects Against Methotrexate-Induced Hepatic Injury in Rats

Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Protective effect of grape seed and skin extract on high dosage garlic-induced renal oxidative stress

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