Effect of resveratrol on behavioral, biochemical, and immunological parameters of DBA/2J and tetrahybrid DBCB mice receiving diet with excess fat and fructose

Трусов, Н В; Шипелин, В А; Mzhel'skaya, K V; Шумакова, А А; Timonin, A N; Ригер, Н. А.; Apryatin, S A; Gmoshinski, I. V.

doi:10.1016/j.jnutbio.2020.108527

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Note that RSV supplementation increased the HDL content, as well as decreased the LDL content, which were significant risk factors related to fatty liver. Overall, this is consistent with the known data on the lipid-lowering effects of RSV from several previous studies ( 33 , 34 ). On the other hand, digestive enzyme activity is considered as an index to evaluate the digestion and absorption ability of fish, reflecting the response of fish to environmental changes.…”

Section: Discussionsupporting

confidence: 93%

Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

Fan

et al. 2022

Front. Immunol.

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High-fat diet is regarded as crucial inducers of oxidative stress, inflammation, and metabolic imbalance. In order to investigate the ameliorative potential of resveratrol against the progression of liver injury towards steatohepatitis, common carp (Cyprinus carpio) were distributed into six experimental groups and were fed with a normal-fat diet, a high-fat diet, and supplemented with resveratrol (0.8, 1.6, 2.4, and 3.2 g/kg diet) for 8 weeks. The high-fat diet decreased the antioxidant capacities, as well as causing the inflammatory response and lipid deposition of common carp. Resveratrol induced a marked elevation in the final body weight, weight gain rate, condition factor and significant decrease in the feed conversion ratio. Moreover, dietary resveratrol showed a significant decrease in the alanine aminotransferase, aspartate aminotransferase, triglyceride and low-density lipoprotein levels, which was accompanied by an increase in high-density lipoprotein concentration in serum. A significant elevation in total superoxide dismutase, catalase, glutathione peroxidase and a decreased malondialdehyde content were observed, along with a substantial elevation in antioxidant activities were found. Additionally, fish fed with resveratrol had an up-regulation of hepatic catalase, copper, zinc superoxide dismutase, glutathione peroxidase 1a, and glutathione peroxidase 1b gene expression via Nrf2 signaling pathway. Expectedly, our results also demonstrated that resveratrol regulates hepatic lipid metabolism in fish by inhibiting the expression of hepatic lipogenesis genes (acetyl-CoA carboxylase 1, fatty acid synthase, and sterol regulatory element binding protein 1), fatty acid uptake-related genes of lipoprotein lipase, and β-oxidation-related genes via PPAR-γ signaling pathway. Furthermore, dietary resveratrol reduced inflammation, as evident by down-regulating the interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α expression levels and upregulating the interleukin-10 and transforming growth factor-β2 expression levels via NF-κB signaling pathway. As a whole, our results demonstrated that resveratrol defensed the impacts against high-fat diet on the serum biochemical, hepatic antioxidants, inflammation, and lipid metabolism.

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Section: Discussionsupporting

confidence: 93%

Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

Fan

et al. 2022

Front. Immunol.

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“…Two strains of mice were used, of which the first, DBA/2J, is characterized by resistance to the development of diet-induced obesity. The second strain—a complex hybrid of the second generation obtained earlier in our laboratory—easily developed signs of diet-induced obesity and fatty liver degeneration when consuming a diet with excess fat and fructose, as was shown earlier in the study [ 13 ].…”

Section: Introductionsupporting

confidence: 55%

Effects of Tyrosine and Tryptophan Supplements on the Vital Indicators in Mice Differently Prone to Diet-Induced Obesity

Gmoshinski

Шипелин

Трусов

et al. 2021

IJMS

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We studied the effects of the addition of large neutral amino acids, such as tyrosine (Tyr) and tryptophan (Trp), in mice DBA/2J and tetrahybrid mice DBCB receiving a high-fat, high-carbohydrate diet (HFCD) for 65 days. The locomotor activity, anxiety, muscle tone, mass of internal organs, liver morphology, adipokines, cytokines, and biochemical indices of animals were assessed. The Tyr supplementation potentiated increased anxiety in EPM and contributed to a muscle tone increase, a decrease in the AST/ALT ratio, and an increase in protein anabolism in both mice strains. Tyr contributed to a decrease in liver fatty degeneration and ALT reduction only in DBCB that were sensitive to the development of obesity. The addition of Trp caused an increase in muscle tone and potentiated an increase in anxiety with age in animals of both genotypes. Trp had toxic effects on the livers of mice, which was manifested in increased fatty degeneration in DBCB, edema, and the appearance of micronuclei in DBA/2J. The main identified effects of Tyr on mice are considered in the light of its modulating effect on the dopamine neurotransmitter metabolism, while for the Trp supplement, effects were presumably associated with the synthesis of its toxic metabolites by representatives of the intestinal microflora.

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“…Ниже представлены таблицы результатов сравнения подопытной группы 1, подопытной группы 2 с контрольной группой на 43 и 53 день эксперимента (Табл. [1][2][3][4] Биохимические анализы крови имели небольшие изменения. Так как выборка животных была небольшая, невозможно точно утверждать о до-стовернности данных результатов, требуются дополнительные исследования с более большой выборкой животных.…”

Section: результаты и обсуждениеunclassified

“…Полученные результаты анализов частично совпадают с систематическим обзором и метаанализом рандомизированных контролируемых клинических испытаний в медицине, в ходе которых выполнялась оценка влияния добавок карнитина на сывороточные уровни ферментов [2,7,8,9].…”

Section: результаты и обсуждениеunclassified

Studies of biochemical parameters of the blood of laboratory animals when studying the subchronic toxicity of the drug L-carnitine

Sabirzyanova,

Lunegov,

Konovalova

et al. 2024

jour

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L-carnitine is a vitamin-like compound that is synthesized in the human or animal body from the amino acids methionine and lysine. Today, L-carnitine is used in cardiology, neurology, gastroenterology and is a substance necessary for the functioning of the body. It normalizes metabolic processes, stimulates cellular energy exchange, eliminates energy deficiency, strengthens the immune system, relieves overwork and fatigue, increases the body's adaptive capabilities, and reduces muscle weakness. Protected L-carnitine is used in dairy farming for metabolic diseases, but only as a feed additive. The purpose of our research is to study the injectable form of L-carnitine, which has not previously been registered in the Russian Federation. Toxicity studies were conducted on outbred rats in October 2021 in the vivarium of the St. Petersburg State University of Veterinary Medicine. The study involved females weighing 190-210 grams, purchased from the Federal State Unitary Enterprise “Nursery of Laboratory Animals “RAPPOLOVO”. When studying subchronic toxicity when administered subcutaneously, L-carnitine was administered at 2 dose levels. Doses were determined based on the results of the acute toxicity experiment: 1/5 and 1/10 of the maximum tolerated dose. The first experimental group (n=10) received the drug subcutaneously at a dose of 0.08 mg/kg (1/5 of 2000 mg/kg). The second experimental group (n=10) received the drug subcutaneously at a dose of 0.04 mg/kg (1/10 of 2000 mg/kg). The control group (n=10) received subcutaneous sodium chloride 0.09% at a dose of 1/5 of 2000 mg/kg. The drug was administered subcutaneously daily for 42 days. Slaughter and sampling of biological material from 5 animals from each group were carried out the next day after the end of the drug administration (day 43), and 10 days after the last drug administration (day 53). As a result of studies of subchronic toxicity on laboratory animals of the drug L-carnitine for veterinary use when administered subcutaneously, it was established that a dosage of 1/5 of the maximum tolerated, and a dosage of 1/10 of the maximum tolerated, does not cause external signs of toxicosis and death in rats . No significant changes were found in the biochemical parameters of the blood of animals in the experimental and control groups.

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Effect of resveratrol on behavioral, biochemical, and immunological parameters of DBA/2J and tetrahybrid DBCB mice receiving diet with excess fat and fructose

Cited by 9 publications

References 24 publications

Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

Resveratrol ameliorates oxidative stress, inflammatory response and lipid metabolism in common carp (Cyprinus carpio) fed with high-fat diet

Effects of Tyrosine and Tryptophan Supplements on the Vital Indicators in Mice Differently Prone to Diet-Induced Obesity

Studies of biochemical parameters of the blood of laboratory animals when studying the subchronic toxicity of the drug L-carnitine

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