Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study

Abstract

Treatment of knee osteoarthritis (OA) remains a challenging concern. Preclinical studies provided accumulating evidence on resveratrol efficacy in ameliorating degenerative articular damage. The present study was conducted to evaluate the effects of resveratrol as monotherapy on the serum level of type II collagen (Coll 2-1) and aggrecan in patients with knee osteoarthritis. The study was an open-labeled noncontrolled clinical trial. Resveratrol 500 mg/day in a single oral dose was given to the patients with knee osteoarthritis for 90 days. The serum levels of Coll-2-1, aggrecan, and biomarkers of inflammation were measured pre- and posttreatment. Hematological profiles and both hepatic and renal function markers were investigated at the baseline and at the end of the treatment for evaluating the tolerability and safety of resveratrol. Visual Analog Scale (VAS) for pain and Knee injury and Osteoarthritis Outcome Score (KOOS) for disease activity were clinically assessed monthly. Administration of 500 mg resveratrol for three months led to a nonsignificant decrease in the serum level of Coll 2-1 while a significant increase in aggrecan serum level. Resveratrol significantly improves pain score measured by VAS and KOOS after 30 days. Improvements in patients’ activity and functional status were also evident at day 30 and kept on for three months which was reflected by KOOS subscale scores and with a significant improvement in all KOOS areas. In conclusion, oral administration of resveratrol as a monotherapy provides a remarkable improvement in the clinical status of the patients but has no significant effect on serum levels of Coll 2-1.

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

“…Two recent clinical studies confirmed the involvement of resveratrol in managing knee OA pain and its associated symptoms [ 51 , 67 ]. Supplementation of 500 mg/day resveratrol led to increased aggrecan serum levels and significantly improved pain, although no significant decrease in serum levels of IL-6, IL-1β, and TNF- α was observed [ 56 ].…”

“…This nutraceutical has many health-benefiting properties, including its anti-inflammatory, antioxidant, and anticancer properties. By modulating major oxidative stress signaling pathways, resveratrol has become one of the most studied nutraceuticals in managing degenerative diseases such as OA [ 51 , 52 , 54 , 55 , 56 , 57 , 67 ] ( Table 1 ).…”

“…In vivo and in vitro studies provided more detailed mechanistic information on the resveratrol’s actions in modulating pain, reducing inflammation, and exerting a protective effect in OA patients [ 51 , 52 , 55 , 57 ]. Its protective effects were demonstrated in an in vivo model where resveratrol ameliorated inflammatory damage in a rat OA model [ 55 ] through its impact on the NF-κB and HO-1/Nrf-2 signaling pathway [ 52 ].…”

Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials

“…In a further study, Marouf et al found that oral RES (500 mg/day) for 90 days significantly improved patients’ knee pain and mobility but had no significant effect on patients’ serum Col-II levels. However, due to the limitations of the trial, such as short intervention time, small sample size, and no control group, further studies are needed to confirm the results in the future ( Marouf, 2021 ). Furthermore, pain is one of the common complaints of postmenopausal women.…”

Deep Learning-Based CT Imaging to Evaluate the Therapeutic Effects of Acupuncture and Moxibustion Therapy on Knee Osteoarthritis

“…Middle-aged and older adults are primarily affected by KOA. Secondary KOA is usually caused by a variety of joint diseases, including joint injuries, fractures, joint fractures, and joint ligament strains [ 6 – 8 ]. According to statistics, 3% of people in China suffer from KOA.…”