Effect of retinol on interaction of the protein period1, oxytocin, and GABA at the prenatal period of formation of the circadian clock-mechanism in rats

Chernysheva, M. P.; Романова, И. В.; Mikhrina, A. L.

doi:10.1134/s002209301301012x

Cited by 3 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was revealed that retinol metabolites affect clock genes and the formation of the circadian rhythm. Disturbances of the lighting conditions before the end of the circadian clock mechanism formation may have negative consequences for the metabolic and behavioral functions of offspring [Bishnupuri, Haldar, 2000;Chernysheva et al, 2012;Chitimus et al, 2020].…”

Section: Discussionmentioning

confidence: 99%

“…Our study showed that the transfer of rats to the constant darkness conditions after birth affected the retinol level in the liver. The circadian clock mechanism forming in the offspring adapts to the "disconnection" from the mother's metabolic clock and "switching over" to the circadian light variation cycles [Chernysheva et al, 2012]. Changing the lighting condition immediately after birth was of great importance for the retinol level, since significant differences were observed in comparison with the control as well as with DD/DD rats.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of long-term constant darkness on retinol in peripheral tissues of rats

Ильина,

Баишникова,

Хижкин

et al. 2023

Proceedings of KarRC of RAS

View full text Add to dashboard Cite

The study was designed to investigate the effect of exposure to long-term constant darkness, starting from the prenatal period or from birth, on the retinol (vitamin A) content in tissues of rats. Females were kept in standard light (LD) or in constant darkness (DD) during pregnancy. The LD females and their offspring after birth were divided into two groups, one of which was left in the same lighting conditions (LD, control), and the other group was switched to the darkness regime (LD/DD). The DD females and their offspring (DD/DD) were kept in the dark. Adults and the young were separated after the suckling period. The retinol content in offspring's tissues (liver, kidneys, heart and skeletal muscle) was determined at the age of 2 weeks, 1, 2, 3, 6, 12, 18 and 24 months by HPLC. Constant darkness had a modulating effect on the age-related dynamics of retinol content in the tissues. The level of the vitamin was higher compared to the control animals in the liver of 2-week-old LD/DD rats and in the kidneys of 1-month-old rats of both experimental groups. The retinol content in the heart of 2-month-old DD/DD rats, on the contrary, was significantly lower than in the control. The retinol level in the liver of 12-month-old LD/DD rats was higher compared to the control animals. The effect of constant darkness on retinol level in tissues depended on the ontogenesis stage at which the experimental exposure began, the tissue type, and the animal's age. The retinol content in the tissues of rats kept in constant darkness indicates metabolic changes that were more pronounced in young animals. K e y w o rd s: vitamin A; constant darkness; light; circadian rhythm; age F o r c i t a t i o n: Ilyina T. N., Baishnikova I. V., Khizhkin E. A. Effect of long-term constant darkness on retinol in peripheral tissues of rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of long-term constant darkness on retinol in peripheral tissues of rats

Ильина,

Баишникова,

Хижкин

et al. 2023

Proceedings of KarRC of RAS

View full text Add to dashboard Cite

show abstract

“…The latter prompted to search for biological or even molecular clock in various experimental animals and their organs. Note that the circadian clock mechanism does not only involve dedicated receptors, but also interplay between those responsible for neurotransmission, for example, GABA and oxytocin (Chernysheva et al, 2013).…”

Section: Cardiac Clockmentioning

confidence: 99%

Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

View full text Add to dashboard Cite

Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

show abstract

Impacts of vitamin A deficiency on biological rhythms: Insights from the literature

Xiang-rong

Wang

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Vitamin A is essential for brain function, in addition to its important roles in vision, immunity, and reproduction. Previous studies have shown that retinoic acid (RA), the bioactive form of vitamin A, is involved in the regulation of various intracellular responses related to biological rhythms. RA is reported to affect the circadian rhythm by binding to RA receptors, such as receptors in the circadian feedback loops in the mammalian suprachiasmatic nucleus. However, evidence of the impacts of vitamin A deficiency (VAD) on biological rhythms is limited, and most of the related studies were conducted on animals. In this review, we described the physiological functions of biological rhythms and physiological pathways/molecular mechanisms regulating the biological rhythms. We then discussed the current understanding of the associations of VAD with biological rhythm disorders/diseases (sleep disorders, impairments in learning/memory, emotional disorders, and other immune or metabolism diseases) and summarized the currently proposed mechanisms (mainly by retinoid nuclear receptors and related proteins) for the associations. This review may help recognize the role of VAD in biological rhythm disorders and stimulate clinical or epidemiological studies to confirm the findings of related animal studies.

show abstract

Effect of retinol on interaction of the protein period1, oxytocin, and GABA at the prenatal period of formation of the circadian clock-mechanism in rats

Cited by 3 publications

References 20 publications

Effect of long-term constant darkness on retinol in peripheral tissues of rats

Effect of long-term constant darkness on retinol in peripheral tissues of rats

Probability that there is a mammalian counterpart of cardiac clock in insects

Impacts of vitamin A deficiency on biological rhythms: Insights from the literature

Contact Info

Product

Resources

About