Effect of RH-5992 on adult development in the spruce budworm, Choristoneura fumiferana

Sundaram, Meenakshi; Palli, Subba Reddy; Smagghe, Guy; Ishaaya, I.; Feng, Qili; Primavera, M.J.; Tomkins, William; Krell, Peter J.; Retnakaran, Arthur

doi:10.1016/s0965-1748(01)00111-4

Cited by 39 publications

(29 citation statements)

References 26 publications

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“…Similarly, curled and poorly formed wings were seen in the Lepidoptera Heliothis zea (Boddie) (Noctuidae), Diatraea grandiosella (Dyar) (Pyralidae), S. exigua, S. littoralis, and Choristoneura fumiferana (Clemens) (Tortricidae) (Chandler et al 1992, Trisyono & Chippendale 1998, Carton et al 1998, Sundaram et al 2002, Pineda et al 2004 adults when exposed to tebufenozide, methoxyfenozide or a combination of both compounds as larvae or pupae. It is important to point out that in our study the hind wings were severely affected, and in some cases, they were even vestigial.…”

Section: Discussionmentioning

confidence: 93%

“…These results, similar to our own, can be explained by the accumulation and persistence of ecdysone agonists in the larval tissue until the pupal molt, at which point the agonist kills the insect. In addition, Sundaram et al (2002) reported the presence of an ecdysone receptor complex in the lepidopteran pupae, so it is clear that this life stage is just as susceptible to ecdysone agonists as larval stage.…”

Section: Discussionmentioning

confidence: 99%

“…We used ifth instars because in other studies we have reported lethal and subethal effects on this developmental stage when ecdysone agonists were applied to different lepidopteran pests (Gobbi et al 2000, Sundaram et al 2002, Biddinger et al 2006. The quantities of methoxyfenozide used correspond to the LC 10 and LC 25 values for this insecticide, which were estimated from a preliminary study (Zarate 2008).…”

Section: Bioassaysmentioning

confidence: 99%

“…Ecdysone agonists are highly selective against lepidopteran larvae, with the result that other insects are often less affected by them (Silhacek et al 1990, Schneider et al 2003. In addition, their narrow spectrum of activity, positive ecotoxicological pro ile, and short persistence in the environment makes these compounds promising against many economically important agriculture and forest pests (Sundaram et al 2002, Biddinger et al 2006, Osorio et al 2008.…”

Section: Introductionmentioning

confidence: 99%

“…These effects include delayed or accelerated developmental time (Adel & Sehnal 2000, Biddinger et al 2006, weight loss of both larvae and pupae (Pineda et al 2007, Zamora et al 2008, mortality and pupae deformations (Gobbi et al 2000, Pineda et al 2004, wing deformities in adults (Trisyono & Chippendale 1998, Sundaram et al 2002, disturbed diapause (Eizaguirre et al 2007), impaired reproductive parameters (Seth et al 2004, Smagghe et al 2004, and changes in the adult sex ratio (Biddinger et al 2006). In addition, Hoelscher & Barret (2003) reported that methoxyfenozide interfered with the ability of Argyrotaenia velutinana (Walker) and Choristoneura rosaceana (Harris) (Lepidoptera: Tortricidae) adult males to respond to the pheromones of sexually mature females.…”

Section: Introductionmentioning

confidence: 99%

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Lethal and Sublethal Effects of Methoxyfenozide on the Development, Survival and Reproduction of the Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Zarate¹,

Díaz²,

Martínez³

et al. 2011

Neotrop. entomol.

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The lethal and sublethal effects of the ecdysone agonist methoxyfenozide on the fall armyworm, Spodoptera frugiperda (J. E. Smith), were investigated by feeding a methoxyfenozide-treated diet to ifth instars until pupation in doses corresponding to the LC 10 and LC 25 for the compound. Larval mortality reached 8% and 26% in the low and high concentration groups, respectively, on the seventh day of the experiment. A progressive larval mortality of 12% for the LC 10 and 60% for the LC 25 was observed before pupation. Treated larvae exhibited lower pupal weights, higher pupal mortality, presence of deformed pupae, and more deformed adults than untreated larvae. The incorporation of methoxyfenozide into the diet had a signi icant effect on the timing of larval development. The development period for males and females was about seven days longer than the controls for both concentrations tested. In contrast, the compound affected neither pupae nor adult longevity. Finally, S. frugiperda adults that resulted from ifth instars treated with methoxyfenozide were not affected in their mean cumulative number of eggs laid per female (fecundity), nor percentages of eggs hatched (fertility), or the sex ratio. Our results suggest that the combination of lethal and sublethal effects of methoxyfenozide may have important implications for the population dynamics of the fall armyworm.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Bioassaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lethal and Sublethal Effects of Methoxyfenozide on the Development, Survival and Reproduction of the Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Zarate¹,

Díaz²,

Martínez³

et al. 2011

Neotrop. entomol.

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Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae

Beckage

Marion

Walton

et al. 2004

Arch Insect Biochem Physiol

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Ecdysone agonists are hormonally active insect growth regulators that disrupt development of pest insects and have potential for development as insecticides. Their effects have been particularly well-studied in Lepidoptera and Coleoptera, but significantly less is known about their effects on dipterans, particularly aquatic species. The potency of three ecdysone agonists on larvae of 3 mosquito species, Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus, was examined. Anopheles gambiae was the most susceptible species and Ae. aegypti was the most resistant species to the effects of the three compounds tested. Potency, in descending order, was RH-2485 > RH-5992 > RH-5849. Dose-response relationships were determined for the three agonists; RH-2485 was found to be the most effective endocrine disruptor against all three species. The observed biological effects of these compounds were similar to those reported for other insects, and mosquitoes initiated molting and apolysis but did not complete a molt. In some cases, mosquito larvae synthesized a new cuticle that appeared to be normally sclerotized but the larvae failed to ecdyse and shed the exuvium. These compounds may prove to be valuable insect growth regulators for control of mosquitoes to decrease the frequency of pathogen transmission to humans. Prospects for using these compounds to control mosquitoes in the field are discussed, along with possible impacts on non-target arthropods in mosquito habitats.

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Diapause disruption with tebufenozide for early‐instar control of the spruce budworm, Choristoneura fumiferana

Doucet

Frisco

Cusson

et al. 2007

Pest Management Science

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In North America, the eastern spruce budworm, Choristoneura fumiferana Clem., is an important coniferous pest against which tebufenozide has proven effective as a control product. By acting as an ecdysone agonist, tebufenozide can induce precocious moulting in late (fifth-sixth) instars but can also be carried over to the next generation owing to its persistence on foliage. The authors conducted laboratory experiments on first-instar larvae treated with tebufenozide dissolved in acetone. Larvae exposed to doses equal to or above 0.1 microg cm(-2) displayed precocious moulting in the second instar after hibernaculum spinning, which effectively disrupted diapause. Larger doses induced moulting in first instars. Evidence is provided that this dose-response difference is related to whether or not an effective dose of tebufenozide is ingested by the first instar prior to the peak of moulting hormone (20-hydroxyecdysone) in first instars. Doses ineffective to kill first instars are carried over to the second instar, where they induce a precocious moult. This type of response to tebufenozide is dependent on the presence of a moulting machinery (the EcR-USP receptor complex) that is ready for ecdysone transduction. Interestingly, ecdysone levels are low in second instars, as measured by a radioimmunoassay, which suggests that diapause in spruce budworm is maintained by a suppression of ecdysone production. Thus, diapause disruption by tebufenozide may well provide an alternative control strategy for this important pest.

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Effect of RH-5992 on adult development in the spruce budworm, Choristoneura fumiferana

Cited by 39 publications

References 26 publications

Lethal and Sublethal Effects of Methoxyfenozide on the Development, Survival and Reproduction of the Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Lethal and Sublethal Effects of Methoxyfenozide on the Development, Survival and Reproduction of the Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae

Diapause disruption with tebufenozide for early‐instar control of the spruce budworm, Choristoneura fumiferana

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