Background: Post-spinal anesthesia hypotension during cesarean delivery is caused by decreased systemic vascular resistance due to the blockage of autonomic nerves, which is further worsened by inferior vena cava (IVC) compression by the gravid uterus. The aim of this study was to assess whether peak velocity and diameter of IVC below the xiphoid or the right common femoral vein (RCFV) in the inguinal region, as measured on ultrasound, could reflect the degree of IVC compression and further identify parturients at risk of post-spinal hypotension.Methods: After 56 parturients underwent elective cesarean section with spinal anesthesia were included in this study, peak velocities and anteroposterior diameters of the IVC and peak velocities and transverse diameters of the RCFV were measured by ultrasound before anesthesia. The primary outcome was ultrasound measurements of IVC and RCFV, and their association with post-spinal hypotension during cesarean delivery. Hypotension was defined as having a drop of systolic arterial pressure >20% from the baseline. Multinomial logistic regression analysis was used to identify the association between the measurements of IVC, RCFV and post-spinal hypotension during cesarean delivery. Receiver operating characteristic curves were used to test the abilities of the identified parameters to predict post-spinal hypotension, and the areas under the curve and the optimum cut-off values for the predictive parameters were calculated.Results: Longer transverse diameter of the RCFV was associated with the occurrence of post-spinal hypotension (odds ratio = 2.022, 95% confidence interval [CI] 1.261–3.243). The area under the receiver operating characteristics curve for the prediction of post-spinal hypotension was 0.759 (0.628–0.890; P = 0.001). A transverse diameter of the RCFV >12.2 mm could predict post-spinal hypotension during cesarean delivery.Conclusions: We demonstrated a longer transverse diameter of RCFV was associated with hypotension and it could predict parturients at major risk of hypotension before anesthesia.Trial Registration: This study was registered at http://www.chictr.org.cn on 16, May, 2018. No. ChiCTR1800016163