Effect of RNAi-Mediated Survivin and Hypoxia-Inducible Factor 1α Gene Silencing on Proliferation, Invasion, Migration and Apoptosis of Gastric Cancer BGC-823 Cells
Abstract:Objective: To investigate the effect of RNAi-mediated survivin and Hypoxia-inducible factor 1α (HIF-1α) gene silencing on proliferation and apoptosis of gastric cancer BGC-823 cells.Methods: Small interfering RNAs (siRNAs) targeting survivin and HIF1α mRNAs were designed and synthesized, respectively, while scrambled siRNAs (SCRs) were synthesized. The hypoxia sensitive gastric cancer line BGC-823 was identi ed and transfected by Hifectin II in vitro under hypoxia condition. The cells transfected with siRNA-su… Show more
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