Effect of Rodent Control Program on Incidence of Zoonotic Cutaneous Leishmaniasis, Iran

Abdoli, Amir; Mazaherifar, Samaneh; Solhjoo, Kavous; Zargar, Mohsen Farhang; Jahromi, Hayedeh Parvin; Taghipour, Ali; Darayesh, Mohammad; Badri, Milad; Pirestani, Majid; Falahi, Shahab; Kenarkoohi, Azra

doi:10.3201/eid3007.231404

Emerg. Infect. Dis.

2024

DOI: 10.3201/eid3007.231404

|View full text |Cite

Effect of Rodent Control Program on Incidence of Zoonotic Cutaneous Leishmaniasis, Iran

Amir Abdoli,

Samaneh Mazaherifar,

Kavous Solhjoo

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Detection of Leishmania RNA Virus 2 (LRV2) among Clinical Isolates of Leishmania Major in Four Endemic Regions of Iran

Mazaherifar,

Erfanian,

Solhjoo

et al. 2024

Acta Parasit.

View full text Add to dashboard Cite

Detection of Leishmania RNA Virus 2 (LRV2) among Clinical Isolates of Leishmania Major in Four Endemic Regions of Iran

Mazaherifar,

Erfanian,

Solhjoo

et al. 2024

Acta Parasit.

View full text Add to dashboard Cite

In Vitro Antileishmanial and Immune Modulation of Trigonelline Against Leishmania major

Esmaeili,

Dezaki,

Amini‐Khoei

et al. 2024

Parasite Immunology

View full text Add to dashboard Cite

The mechanistic study of new pharmaceutical compounds is crucial for evaluating their efficacy, identifying potential side effects, and optimising drug formulations. This study aimed to investigate the mechanism of action of trigonelline on the promastigote and amastigote stages of Leishmania major (MRHO/IR/75/ER). An initial in silico study was conducted to examine the pharmacological effects of trigonelline using molecular docking to evaluate the potential binding affinity of trigonelline with nitrate, a crucial molecule in the macrophage immune response against Leishmania. In this experimental study, the inhibitory mechanism of trigonelline on promastigotes was evaluated by measuring metacaspase expression levels. In the amastigote stage of L. major, the expression levels of inducible nitric oxide synthase (iNOS), interleukin 12 (IL‐12), interferon‐gamma (IFN‐γ), tumour necrosis factor alpha (TNF‐α), transforming growth factor‐β (TGF‐β) and interleukin 10 (IL‐10) genes were assessed using Real‐time PCR. Trigonelline demonstrated a high‐binding affinity to the iNOS molecule in computer modelling. In macrophages treated with various concentrations of trigonelline, glucantime and their combination, the expression levels of metacaspase, IL‐12, TNF‐α, IFN‐γ and iNOS genes significantly increased compared to the control group (p < 0.05), whereas IL‐10 and TGF‐β gene expression levels significantly decreased (p < 0.05). Trigonelline exerts its antileishmanial effects through its high antioxidant properties, non‐cytotoxicity to macrophages, and its ability to enhance apoptosis and cell cycle arrest in promastigotes of L. major.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of Rodent Control Program on Incidence of Zoonotic Cutaneous Leishmaniasis, Iran

Cited by 2 publications

References 11 publications

Detection of Leishmania RNA Virus 2 (LRV2) among Clinical Isolates of Leishmania Major in Four Endemic Regions of Iran

Detection of Leishmania RNA Virus 2 (LRV2) among Clinical Isolates of Leishmania Major in Four Endemic Regions of Iran

In Vitro Antileishmanial and Immune Modulation of Trigonelline Against Leishmania major

Contact Info

Product

Resources

About