Effect of rosemary oil extract on biofilm formation by streptococcus mutans-a invitro study

J, Sarvesh Kumar; Geetha,

doi:10.24327/ijcar.2017.3123.0199

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Several researchers have reported the multiple therapeutic benefits of the Mediterranean grown Rosmarinus officinalis such as anti-inflammatory, antioxidant, antibacterial, anti-fungal, antiviral and even anti-cancer potential among many other benefits 40,[42][43][44][45] . Moreover, researchers have reported the ability of rosemary to remineralize initial caries lesions while others have reported the ability of rosemary to inhibit glucosyltransferase and subsequent glucan production of Streptococcus mutans and Streptococcus sorbinus respectively 20,[46][47][48][49][50] . Rosemary has been reported to have antibacterial properties against several cariogenic bacteria including S. mutans in addition to inhibiting its biofilm formation ability wither through their water or alcoholic extracts [50][51][52] .…”

Section: Natural Productsmentioning

confidence: 99%

Inhibition of Glucosyltransferase enzyme of Streptococcus mutans by natural products- A Literature Review

Balbaa,

Taher,

Kamal Hamza

et al. 2023

MSA Dental Journal

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Streptococcus mutans is acid producing, acid tolerant bacteria that is involved in the multifactorial process of dental caries. Streptococcus mutans is considered one of the most cariogenic bacteria of the oral flora capable of causing dental caries alone. This was attributed to its ability to produce extracellular polysaccharides that form the oral biofilm through their glucosyltransferase enzymes. Scientists have searched for a method to selectively target these bacteria or their enzymes in an attempt to prevent caries occurrence. This was previously done through the use of artificial products as Chlorhexidine gluconate, however, most artificial products have undesirable side effects. Therefore, researchers are nowadays researching natural products for their antibacterial properties and their ability to inhibit glucosyltransferase enzymes of Streptococcus mutans without the unnecessary side effects. Hence, the aim of this literature review was to focus on the natural products and their ability to inhibit Streptococcus mutans and its glucosyltransferase enzyme.

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Section: Natural Productsmentioning

confidence: 99%

Inhibition of Glucosyltransferase enzyme of Streptococcus mutans by natural products- A Literature Review

Balbaa,

Taher,

Kamal Hamza

et al. 2023

MSA Dental Journal

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“…Nowadays, scientists have started to target the natural products with antibacterial properties to reduce the chemicals side effects and overcome antimicrobial resistance [10,12,13] . Several researchers have reported the ability of rosemary to remineralize initial caries lesions in addition to its ability to inhibit glucosyltransferase and subsequent glucan production of Streptococcus mutans and Streptococcus sorbinus respectively [14][15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

Balbaa,

Taher,

Hamza

et al. 2024

Egyptian Dental Journal

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Background: Streptococcus mutans are involved in caries by forming biofilm polysaccharides through their glucosyl transferase enzymes. Natural plant extracts can inhibit glucosyl transferase production and bacterial activity. Endophytic fungi inside plant tissues can produce bioactive compounds similar to those produced by their host plants.Aim: Compare the inhibitory effect of rosemary endophytic fungal extract on S.mutans glucosyl transferase to rosemary and chlorhexidine and their effect on enamel microhardness. Methods: Glucosyltransferase was purified from S.mutans. The ability of the total metabolites and endophytic fungi extracted from rosemary to inhibit the purified glucosyltransferase compared to chlorhexidine and artificial saliva.13crowns of human molars were subdivided into 4 equal parts giving 4groups for microhardness and biofilm evaluation. The microhardness was evaluated at baseline and after treating the four subgroups using the rosemary extract, chlorhexidine, artificial saliva and endophytic fungal extract for 24and72h.The biofilm inhibition was tested using SEM after 24and72h.Results: Nine endophytic fungal strains were recovered from rosemary. Chaetomium globosum, Alternaria alternata and Aspergillus niger extracts showed positive inhibitory effect on glucosyltransferase 96.25%, 90.9%and81.74% respectively. While, those of rosemary extract, chlorhexidine and artificial saliva were 36.19%, 86.38%and0.27%. Chaetomium globosum extract showed the highest inhibitory effect on biofilm formation in comparison to chlorhexidine and rosemary extract after 24and72h. The highest microhardness value for all groups was at baseline then microhardness decreased after24 and72h except for Chaetomium globosum and rosemary extract where microhardness increased after72h to be higher than that after24h. Conclusion :Endophytic fungal extract of rosemary can inhibit S.mutans glucosyltransferase and its biofilm formation where it can remineralize initial carious lesions.

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Effect of rosemary oil extract on biofilm formation by streptococcus mutans-a invitro study

Cited by 2 publications

References 4 publications

Inhibition of Glucosyltransferase enzyme of Streptococcus mutans by natural products- A Literature Review

Inhibition of Glucosyltransferase enzyme of Streptococcus mutans by natural products- A Literature Review

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

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