Effect of rosmarinic acid on bull sperm quality and bacteria in semen

Hagos, Lidya; Cojkic, Aleksandar; Hanson, Ingrid; Johannisson, Anders; Ntallaris, Theodoros; Morrell, Jane M.

doi:10.1016/j.anireprosci.2020.106395

Cited by 6 publications

(5 citation statements)

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“…For some other plant-based substances, which were tested for their antibacterial effect in semen samples, an interspecies variation was found. An example is rosmarinic acid that was reported to have an antibacterial effect in boar semen [ 29 , 30 ] but did not have such an effect in bull semen [ 31 ]. Therefore, there may be some components of bull semen that prevent the antibacterial action of rosmarinic acid that is reported to occur when added to boar semen.…”

Section: Discussionmentioning

confidence: 99%

Effect of Some Plant-Based Substances on Microbial Content and Sperm Quality Parameters of Bull Semen

Cojkic

Hansson

Johannisson

et al. 2023

IJMS

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The rapid emergence of antibacterial resistance requires alternatives to antibiotics to be found, including for semen preservation. One of the possible alternatives would be to use plant-based substances with known antimicrobial effects. The objective of this study was to test the antimicrobial effect of pomegranate powder, ginger, and curcumin extract in two concentrations on bull semen microbiota after exposure for < 2 h and 24 h. An additional aim was to evaluate the effect of these substances on sperm quality parameters. The bacterial count in semen was low from the beginning; however, a reduction was present for all tested substances compared with control. A reduction in bacterial count in control samples was also observed with time. Curcumin at a concentration of 5%, reduced bacterial count by 32% and was the only substance that had a slight positive effect on sperm kinematics. The other substances were associated with a decline in sperm kinematics and viability. Neither concentration of curcumin had a deleterious effect on sperm viability parameters measured by flow cytometry. The results of this study indicate that curcumin extract at a concentration of 5% can reduce the bacterial count and does not have a negative influence on bull sperm quality.

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Section: Discussionmentioning

confidence: 99%

Effect of Some Plant-Based Substances on Microbial Content and Sperm Quality Parameters of Bull Semen

Cojkic

Hansson

Johannisson

et al. 2023

IJMS

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“…Sun et al.’s 19 research had found that RosA has antibacterial activity against E. coli and S. aureus , but the sensitivity of S. aureus to RosA is significantly higher than that of E. coli . Hagos et al 20 . found that RosA may have antimicrobial properties while having an antioxidant effect on spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

“…Sun et al's 19 research had found that RosA has antibacterial activity against E. coli and S. aureus, but the sensitivity of S. aureus to RosA is significantly higher than that of E. coli. Hagos et al 20 found that RosA may have antimicrobial properties while having an antioxidant effect on spermatozoa. Li et al 21 found that RosA could inhibit the growths of E. coli, S. aureus, and Rhizotonia with minimum inhibitory concentrations (MIC) of 300, 400, 800 mug/ml, respectively.…”

Section: Introductionmentioning

confidence: 99%

The antibacterial mechanism of perilla rosmarinic acid

Jin-hua

Cui

Zhang

et al. 2021

Biotech and App Biochem

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Rosmarinic acid (RosA) is a phenolic acid compound extracted from perilla. In this experiment, the Oxford cup method was used to verify the antibacterial activity of PerillaRosA against Escherichia coli, Staphylococcus aureus, Salmonella, and Bacillus subtilis. By polyacrylamide gel electrophoresis, the effect of RosA on bacterial nucleic acid and bacterial Na + /K + -ATP-ase activity, and scanning electron microscope to exploration of its antibacterial mechanism preliminarily.The results showed that RosA had antibacterial properties against all four bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of E. coli were 0.8 and 0.9 mg/ml, respectively. The MIC and MBC of Salmonella were 0.9 and 1.0 mg/ml, respectively. The MIC and MBC of S. aureus and B. subtilis were both 1.0 and 1.1 mg/ml. RosA has the bacteriostasis function, which can destroy bacterial cells and cell proteins and inhibit the activity of Na + /K + -ATP-ase in cells.

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“…The Global Antimicrobial Resistance Epidemic -Innovative Approaches and Cutting-Edge Solutions the beneficial effects were due to antioxidant activity but a few extracts also had antibacterial activity. Thus, rosmarinic acid was reported to have an antibacterial effect in boar semen [45,46,48,49] but, according to another report, lacked such an effect in bull semen [50]. Whether these contrasting results reflect the species of animal, type of bacteria present or the source of the rosmarinic acid, or could be attributable to the development of resistance, is not known.…”

Section: Plant Extractsmentioning

confidence: 99%

Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination

Morrell¹,

Malaluang²,

Cojkic³

et al. 2022

The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions

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Antimicrobial resistance is a serious global threat requiring a widespread response. Both veterinarians and medical doctors should restrict antibiotic usage to therapeutic use only, after determining the sensitivity of the causal organism. However, the addition of antibiotics to semen extenders for animal artificial insemination represents a hidden, non-therapeutic use of antimicrobial substances. Artificial insemination for livestock breeding is a huge global enterprise with hundreds of million sperm doses prepared annually. However, reporting of antimicrobial resistance in semen is increasing. This review discusses the consequences of bacteria in semen samples, as well as the effect of antimicrobial substances in semen extenders on bacteria in the environment and even on personnel. Alternatives to antibiotics have been reported in the scientific literature and are reviewed here. The most promising of these, removal of the majority of bacteria by colloid centrifugation, is considered in detail, especially results from an artificial insemination study in pigs. In conclusion, colloid centrifugation is a practical method of physically removing bacteria from semen, which does not induce antibiotic resistance. Sperm quality in stored semen samples may be improved at the same time.

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Effect of rosmarinic acid on bull sperm quality and bacteria in semen

Cited by 6 publications

References 0 publications

Effect of Some Plant-Based Substances on Microbial Content and Sperm Quality Parameters of Bull Semen

Effect of Some Plant-Based Substances on Microbial Content and Sperm Quality Parameters of Bull Semen

The antibacterial mechanism of perilla rosmarinic acid

Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination

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