Effect of Rosmarinic Acid on Experimental Diabetic Nephropathy

Jiang, Wanglin; Xu, Yong; Zhang, Shuping; Hou, Jian; Zhu, Haibo

doi:10.1111/j.1742-7843.2011.00828.x

Cited by 25 publications

(21 citation statements)

References 27 publications

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“…Interestingly, the anti-hyperalgesic and anti-allodynic effects of RA in diabetic animals were not accompanied by changing the plasma glucose level, so the effect of RA on the pain threshold of diabetic rats may not be the result of changing this factor. It has been also reported in previous published works that RA administration in diabetic rats failed to alter hyperglycemia of diabetic rats even at doses higher than used here so it seems that the neuroprotective effects of RA are independent of changing blood glucose of diabetic rats (Jiang et al, 2012;Luan et al, 2013;Sotnikova et al, 2013).…”

Section: Discussionsupporting

confidence: 82%

“…The control groups received saline or RA at the same doses as the diabetic groups by oral gavage. The doses of the RA used here were based on a previously published study and our pilot studies (Jiang et al, 2012). Hyperalgesia and allodynia were assessed at the end of the treatment.…”

Section: Animalsmentioning

confidence: 99%

“…RA has some beneficial bioactivities in diabetes such as neuroprotective, anti-diabetic nephropathy, and vascular dysfunction effects (Luan et al, 2013;Jiang et al, 2012;Sotnikova et al, 2013). Since there are no experimental studies on the effects of RA on diabetic neuropathy, we investigated the effect of long-term oral RA administration on experimental models of thermal/chemical hyperalgesia and tactile allodynia in streptozotocin-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

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Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

Hasanein¹,

Zaheri²

2014

Pharmaceutical Biology

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Context: Diabetic neuropathic (DN) pain is one of the diabetes complications. Rosmarinic acid (RA), a natural phenol antioxidant, shows some biological activities, including anti-inflammatory, analgesic, and anti-diabetic effects. Objectives: We investigated the efficacy of RA administration (10 and 30 mg/kg) on streptozotocin (STZ)-induced neuropathy in rats. Material and methods: The animals received saline or RA (10 and 30 mg/kg, p.o.; once daily) for 8 weeks. DN was evaluated by the tail flick (TF) method, formalin test, and tactile allodynia. At the end, all rats were weighed and underwent plasma glucose measurement. Results: There was an increase in licking time during both formalin test phases in diabetic animals (138.5 ± 10.7 and 448.7 ± 2.6 s) that was decreased by RA10 mg/kg (103.5 ± 7.5 and 284.4 ± 19 s) and RA 30 mg/kg (81.8 ± 11 and 192.7 ± 14 s). RA 30 mg/kg caused anti-nociception during the early phase in treated controls (52.1 ± 6 s) than untreated controls (99.4 ± 5.9 s). The TF latency in diabetics (2.9 ± 0.1 s) was increased in RA10 and 30 mg/kg treated diabetics (5.3 ± 0.4 and 6 ± 0.86 s). The paw withdrawal threshold (PWT) of the diabetics (3.6 ± 0.7 g) was increased after RA 10 and 30 mg/kg (13.8 ± 0.3 and 14 ± 0.4 g) treatment. RA did not induce a significant change in body weight and plasma glucose of rats. Conclusion: RA showed efficacy in amelioration of some aspects of DN. Therefore, RA makes a good candidate for DN treatment in clinical studies.

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Section: Discussionsupporting

confidence: 82%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

Hasanein¹,

Zaheri²

2014

Pharmaceutical Biology

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“…Many bioactivities of RA have been reported, such as anti-liver fibrosis [10], antisepsis [11] and anti-diabetic nephropathy [12]. There is no report which has demonstrated the role of HMGB1 and NF-κB in the neuroprotective effect of RA on diabetic rats with cerebral ischemic injury.…”

Section: Introductionmentioning

confidence: 99%

Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Luan

Kan

et al. 2013

J Neuroinflammation

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Background: Inflammatory activation plays a vital role in the pathophysiological mechanisms of stroke, exerting deleterious effects on the progression of tissue damage and may lead to the vascular damage in diabetes. The objectives of this study were to determine the effects of rosmarinic acid (RA) on a cultured neuronal cell line, SH-SY5Y in vitro and experimental ischemic diabetic stroke in vivo.

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“…RA was found to be potent in the treatment of diabetic nephropathy. It reduced expression of renal connective-tissue growth factor (CTGF) in STZ-induced rat animal models and in high glucose-stimulated HK-2 cells [108] . (3) RA treatment in mice with existing cholestatic liver fibrosis inhibited HSC activation and progression of liver fibrosis via PPARγ derepression mediated by suppression of canonical Wnt signaling in HSCs [109] .…”

Section: Other Pharmacological Findingsmentioning

confidence: 99%

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Wang

2012

Acta Pharmacol Sin

108

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Salvia miltiorrhiza, a traditional medical herb known as danshen, has been widely used in China to improve blood circulation, relieve blood stasis, and treat coronary heart disease. S miltiorrhiza depside salt is a novel drug recently developed at the Shanghai Institute of Materia Medica; it contains magnesium lithospermate B (MLB) and its analogs, rosmarinic acid (RA) and lithospermic acid (LA), as active components. The drug has been used in the clinic to improve blood circulation and treat coronary heart disease. The pharmacological effects of the depside salt from S miltiorrhiza and its components have been extensively investigated. Experimental studies have demonstrated that magnesium lithospermate B possesses a variety of biological activities, especially protective effects in the cardiovascular system such as attenuation of atherosclerosis and protection against myocardial ischemia-reperfusion injury. Rosmarinic acid and lithospermic acid also show beneficial effects on the cardiovascular system. This paper reviews the recent findings regarding the mechanisms underlying the pharmacological actions of the active components of S miltiorrhiza depside salt, based on published works and our own observations.

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Effect of Rosmarinic Acid on Experimental Diabetic Nephropathy

Abstract: Connective tissue growth factor

Cited by 25 publications

References 27 publications

Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

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