The present work aims to investigate the changes in the microstructural and mechanical properties of various pre- and post weld heat treatments (PWHTs) on rotary friction welded dissimilar (AA7075 and AA5083) aluminum alloys. The investigation focused on the evolution of weld macro- and microstructures, as well as the changes in hardness and tensile properties resulting from friction welding. The joint integrity was studied through various characterization techniques, and no cracks or incomplete bonding was observed. The study found that the dissimilar joints of the AA7075 and AA5083 alloys displayed higher flash formation on the AA7075 side, which has a lower melting temperature compared to the AA5083 alloy. Various zones were identified in the weld region, including the dynamic recrystallized zone (DRZ), the thermomechanically affected zone (TMAZ) consisting of TMAZ-1 (elongated grains) and TMAZ-2 (compressed/distorted grains), the heat-affected zone (HAZ), and the base metal (BM) zone. The rotary friction welded sample AA5083/AA7075-PWHT joint exhibited the highest strength (yield strength (YS): 195 ± 3 MPa, ultimate tensile strength (UTS): 387 ± 2 MPa) among all the other welded conditions, and this may be attributed to the major strengthening precipitates MgZn2 (of AA7075) formed during postweld aging. All dissimilar welds failed in the HAZ region of the AA5083 side due to the formation of coarse grains, indicating the weakest region.