Effect of routine inflammatory markers on clinical outcomes in acute basilar artery occlusion after endovascular thrombectomy: Results from ATTENTION registry

Abstract

Background: To investigate the relationship between clinical routine inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), white blood cell count (WBC), neutrophils, lymphocytes, and platelets with clinical outcomes in acute basilar artery occlusion (BAO) patients receiving endovascular treatment (EVT). Methods: We recruited 2,134 acute BAO patients from 48 stroke centers across 22 Chinese provinces in the ATTENTION registry from 2017 to 2021. Blood samples were drawn at admission. An unfavorable functional outcome was defined using a modified Rankin Score (mRS) of 4-6 at 90 days. Safety outcomes included mortality within 90 days and symptomatic intracerebral hemorrhage within 3 days. Results: 1,044 patients were included in the final study. After adjusting for confounding factors, the upper quartiles of WBC and NLR were related to 90-day unfavorable functional outcome (mRS 4–6) compared with those in the lowest quartile (WBC: quartile 4, OR=1.85, 95% CI=1.22–2.80; NLR: quartile 4, OR=2.02, 95% CI=1.34–3.06). The higher quartiles of WBC and NLR were also related to the increased risk of mortality at 90 days. Restricted cubic spline regression analysis showed an incremental trend between NLR and 90-day unfavorable functional outcome (P non-linearity=0.055). In subgroup analysis, a significant interaction was found between NLR and bridging therapy for predicting unfavorable functional outcome (P=0.006). Conclusions: Higher WBC and NLR on admission are significantly related to unfavorable functional outcome and mortality at 90 days in acute BAO patients receiving EVT. Significant interaction was found between increased NLR and bridging therapy on these outcome measures. Clinical Trial Registration-URL: http://www.chictr.org.cn. Unique identifier: ChiCTR2000041117

Cognition after stroke

“…They investigated the relationship of routine clinical inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, mean platelet volume, white blood cell count (WBC), neutrophils, lymphocytes, and platelets, with clinical outcomes in acute BAO patients receiving EVT. 26 In 1044 patients, higher WBC and NLR on admission were significantly related to unfavorable functional outcome and mortality at 90 days in acute BAO patients receiving EVT. This does raise the intriguing possibility that treatment to reduce inflammation might improve outcome after reperfusion therapy.…”