Effect of Royal Jelly on Formalin Induced-Inflammation in Rat Hind Paw

Arzi, Ardeshir; Olapour, Samaneh; Yaghooti, Hamid; Karampour, Neda Sistani

doi:10.17795/jjnpp-22466

Cited by 35 publications

(24 citation statements)

References 21 publications

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“…It is also proven to have a hypotensive effect, antitumor activity, insulin-like action [32] , anti-inflammatory, wound-healing, antibiotic and antifungal activity, and cholesterol-lowering effects. Moreover, RJ improves the fertility in men by increasing the quality of their sperms, and in women by increasing the quality of their ova [33] .…”

Section: Discussionmentioning

confidence: 99%

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Royal jelly protects against experimentally-induced ulcerative colitis in adult male albino rats : A histological study

Ismail

Aboulkhair

2018

Egyptian Journal of Histology

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Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition characterized by acute episodes of colonic inflammation. Its pathogenesis is associated with decreased antioxidant capability. Royal Jelly (RJ) is usually used as a complementary therapy in various diseases because of its antioxidant, anti-inflammatory and immunomodulatory effects. Aim of the work:To evaluate the protective effect of RJ against acetic acid-induced UC in adult male albino rats. Materials and Methods: Thirty rats were divided equally into 3 groups. Group I was the control group. Group II included rats subjected to intracolonic acetic acid (AA) for induction of UC. Group III 10 rats treated with RJ (250 mg/kg/day orally) for 7 days, thereafter subjected to AA. RJ was administered for another 14 days. Rats were sacrificed after 21 days. Serum glutathione (GSH) and malondialdehyde (MDA) were assessed. Colonic sections were subjected to H&E, Periodic Acid Schiff (PAS), toluidine blue, Mallory's trichrome stains and cyclooxygenase-2 (COX-2) immunohistochemical stain. Results: Group II showed significant decrease in GSH, significant increase in MDA and marked histological alterations in colon. There was a significant decrease in the number of goblet cells, but significant increases in the number of mast cells, area% of collagen fibers and COX-2 immunoexpression compared to the control. In group III, GSH was significantly increased and MDA was significantly decreased compared to group II. The colon showed minimal changes, significant increase in the number of goblet cells, significant reduction in the number of mast cells, collagen deposition and COX-2 immunoreactivity compared to group II. When compared to the control, there was no significant difference regards the serological, histological and morphometric results, except for the number of goblet cells that revealed significant decrease. Conclusion: RJ proven to protect against acetic acid-induced UC in albino rats.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have discussed the anti-inflammatory effects of RJ; such as in the kidneys [28] or in soft tissues [33] . Scientists have attributed the immunomodulatory properties of RJ to the presence of neopterin that acts as a chain breaking antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Royal jelly protects against experimentally-induced ulcerative colitis in adult male albino rats : A histological study

Ismail

Aboulkhair

2018

Egyptian Journal of Histology

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“…RJ exhibits a wide variety of functional properties, and has been widely used in cosmetics, healthy foods and commercial medical products in numerous countries. Additionally, RJ possesses various properties, including antimicrobial (2), anti-inflammatory (3,4), hepatoprotective (5), antisarcopenia (6), insulin-like action (7) and antihypercholesterolemic (8) properties. In the recent decades, there have been an increasing number of studies investigating the effects of RJ.…”

Section: Introductionmentioning

confidence: 99%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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Abstract. Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0.5 and 1.5 g/kg); and in the serum, the levels of interleukin (IL)-2 (RJ 0.5 and 1.5 g/kg), interferon (IFN)-α, superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were significantly elevated, but the concentrations of IL-4 (RJ 0.5 and 1.5 g/kg) and IL-10 (RJ 1.0 g/kg) were significantly decreased. In addition, the activities of T-AOC and glutathione reductase (GR) were significantly improved in the liver, whereas in the kidney, the activities of T-AOC and GR were significantly increased only under the dose of 0.5 g/kg. For the TRJ group, the antitumor effect of RJ was not significant; the change in IL-2, IFN-α, SOD and T-AOC levels in the serum, and the change in T-AOC and GR in liver were similar to those observed in the PTRJ groups. RJ treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic-therapeutic method. These results corroborated the efficacy of RJ supplementation in diets. The results of the present study suggest that the antioxidant and immunomodulatory activities of RJ serve an important role on antitumor growth.

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“…Carrageenan (1%) in 0.9% normal saline was prepared 30 minutes before each experiment session and a volume of 0.05 ml was injected into plantar side of hind paw of the rats. Carrageenan injection in all groups [24,25]. The ability of anti-inflammatory agents to suppress paw inflammation was expressed as a percent inhibition of paw edema and calculated according to the following equation:…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Evaluation Effect of Probiotic Cream in Carrageenan-Induced Inflammation Model in Male Rat Hind Paw

Saadatzadeh¹,

Karampour²,

Imari³

et al. 2018

Eurasian J Anal Chem

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Background:Inflammation is the first biological response produced by immune system against any infections or foreign allergen in order to protect the body. The main anti-inflammatory drugs that are used today are Non-steroidal anti-inflammatory drugs (NSAID), opioids, and corticosteroids. Despite the broad range of uses of these drugs, many side effects have been associated with their use such as digestive problems like ulcers and peptic bleeding. It has been suggested that products containing probiotics can be used as an effective anti-inflammatory drug, due to effects of Probiotics on immune responses such as reducing the inflammatory cytokines. In this study, we aim to investigate the anti-inflammatory effects of probiotics and to compare the effect with commonly used drugs such as Piroxicam and Calandula in an animal model. Method:In this experimental study, after preparation of topical probiotic cream, used Wistar male rats weighing 180-200 g were used and randomly divided into 6 groups; negative control, positive control (piroxicam & calandula) and 3 treatment groups (2%, 4% and 8% w/w of LPE). Three groups, each received different doses (2%, 4% and 8% w/w) of LPE cream by topical use was 30 minutes before injecting carrageenan into plantar side of hind paw of the rats. Piroxicam gel and Calandula ointment were studied as positive control for anti-inflammatory activity, respectively. Finally, to observe the anti-inflammatory effect, the rat paw edema was measured every 15 min in the first hour and then hourly for 5 hours. In the end, the volume of intact rat ҆ s paw was measured in all groups by using plethysmometer. In the study, the IL-6 levels was measured by the ELIZA method.Result: All groups under the administration of the probiotic extract of Lactobacillus Casei compared to the negative control group in the rat paw edema show significant difference (P<0.05). Dose 2% LPE (Lyophilized cell free Probiotic Extract), turned out to be less effective than 2% Piroxicam cream in reducing edema during the study. But there was no significant difference between the group receiving doses of 4% and 8% w/w. The 4% dose of LPE cream was selected as the most favorable. These effects may be due, at least in part, to the pro-inflammatory cytokine production of IL-6 and TNFα. Also, all the groups under the administration of probiotic extract of Lactobacillus Casei were compared to the Calandula Officinalis group in the male rat paw and it was seen that there was no significant difference between them. Conclusion:The results of this study showed that LPE cream can improve inflammation effects in hand paw edema. Saadatzadeh et al. / Evaluated Anti-inflammatory Effect of Probiotics Cream / 12

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Effect of Royal Jelly on Formalin Induced-Inflammation in Rat Hind Paw

Cited by 35 publications

References 21 publications

Royal jelly protects against experimentally-induced ulcerative colitis in adult male albino rats : A histological study

Royal jelly protects against experimentally-induced ulcerative colitis in adult male albino rats : A histological study

The effect of royal jelly on the growth of breast cancer in mice

Evaluation Effect of Probiotic Cream in Carrageenan-Induced Inflammation Model in Male Rat Hind Paw

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