Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival

Antoniou, Efstathios; Deroover, Arnaud; Nishimura, Youji; Howie, Alexander J.; McMaster, P; D’Silva, Milbhor

doi:10.1007/978-3-662-00818-8_82

Cited by 1 publication

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“…1 This model has since been extensively used in various strain combinations to test the efficacy of new immunosuppressive drugs. 3,4 In 1970, Tamai et al 5 developed a technique for free rectus femoris muscle transplant in the dog. Thereafter, numerous models of free muscle transfer in the rat have been described, including the use of the latissimus dorsi and serratus anterior, 6 pectoralis major, 7 gracilis, 8 gastrocnemius, 9 and rectus abdominis.…”

Section: Discussionmentioning

confidence: 98%

A new rat model to study the correlation of cardiac and skeletal muscle allograft rejection

et al. 1998

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As a first step to study the correlation of cardiac and skeletal muscle allograft rejection, we describe a new experimental rat model of simultaneous heterotopic heart and cutaneous maximus muscle flap allotransplant. Brown Norway rats were used as donors and Lewis rats as recipients. No immunosuppression was given. The grafts were revascularized with sequential end-to-side anastomosis of each vascular pedicle to the infrarenal aorta and vena cava. Syngeneic heart and cutaneous maximus muscle grafts remained functional and showed no sign of rejection at 7 days after the transplant. In contrast, both allografts developed severe rejection and functional compromise at 7 days after the transplant. Our experimental model is technically feasible and reproducible and may provide important information about the pattern of rejection of cardiac and skeletal muscle allografts.

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