Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine

Ahn, Jung Hwan; Kim, Junhyeong; Rehman, Naveed Ur; Kim, Hye-Jin; Ahn, Mi‐Jeong; Chung, Hanshik

doi:10.3390/pharmaceutics12060547

Cited by 11 publications

(13 citation statements)

References 51 publications

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“…Microencapsulation [2][3][4]11,16,18,20,[23][24][25][26][27] Already established and yet to be improved methods are as follows: 6. Microcapsule Characterization: 3,15,26 Microcapsule is a significant technology by which a feasible protein, active agent or antigen medium can be developed.…”

Section: Recent Developments Inmentioning

confidence: 99%

“…16 In many cases, conventional drug delivery provides sharp increase in drug concentration often achieving toxic level and following a relatively short period at the therapeutic level of the drug concentration eventually drops off until re-administration. 3,10,17,18 It is necessary to administer an agent to the appropriate tissue in the optimum quantity to be released over the requisite duration of time in order to achieve full therapeutic effectiveness with minimal toxicity and limited side effects.…”

Section: Introductionmentioning

confidence: 99%

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An overview of microcapsule dosage form

Arefin¹,

Habib²,

Chakraborty³

et al. 2021

IJPCA

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Microcapsules offer a wide variety of convenience in drug delivery when compared with conventional dosage forms. It is a unique carrier system for many pharmaceuticals. Microencapsulation is a potential process which prolongs the efficacy of drug significantly and improves patient compliance. This approach can alleviate the limitations of dose dumping, multiple dose inconvenience, kidney disease. This dosage form has potential advantages for elderly people who have to take multiple drugs. But microcapsule preparation needs method and formulation optimization and proper characterization. In this review paper, we have discussed the advantages, limitation of the microcapsules and microspheres. We have highlighted the applications of microcapsules and microspheres in the pharmaceutical industries. We also discussed the characterization process of microcapsules. Microcapsules open the era of individualized, targeted drug delivery with minimal side effects and greater convenience.

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Section: Recent Developments Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An overview of microcapsule dosage form

Arefin¹,

Habib²,

Chakraborty³

et al. 2021

IJPCA

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show abstract

“…Administration of herbal drugs to patients using traditional methods, however, is not always the most efficacious. Most phytocompounds experience several shortcomings such as bioavailability problems (low solubility), barrier function of the gastrointestinal tract and intensive primary metabolism [ 8 , 9 ]. Nanotechnology constitutes a distinctive and useful approach to overcome phytocompounds’ physicochemical limitations.…”

Section: Introductionmentioning

confidence: 99%

Multifaced Role of Dual Herbal Principles Loaded-Lipid Nanocarriers in Providing High Therapeutic Efficacity

et al. 2021

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Although many phytochemicals have been used in traditional medicine, there is a great need to refresh the health benefits and adjust the shortcomings of herbal medicine. In this research, two herbal principles (Diosgenin and Glycyrrhiza glabra extract) coopted in the Nanostructured Lipid Carriers have been developed for improving the most desirable properties of herbal medicine—antioxidant and anti-inflammatory actions. The contribution of phytochemicals, vegetable oils and of lipid matrices has been highlighted by comparative study of size, stability, entrapment efficiency, morphological characteristics, and thermal behavior. According to the in vitro MTS and RTCA results, the dual herbal-NLCs were no cytotoxic toward endothelial cells at concentrations between 25 and 100 µg/mL. A rapid release of Glycyrrhiza glabra and a motivated delay of Diosgenin was detected by the in vitro release experiments. Dual herbal-NLCs showed an elevated ability to annihilate long-life cationic radicals (ABTS•+) and short-life oxygenated radicals (an inhibition of 63.4% ABTS•+, while the ability to capture radical oxygen species reached 96%). The production of pro-inflammatory cytokines was significantly inhibited by the newly herbals-NLC (up to 97.9% inhibition of TNF-α and 62.5% for IL-6). The study may open a new pharmacotherapy horizon; it provides a comprehensive basis for the use of herbal-NLC in the treatment of inflammatory diseases.

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“…It is a second-generation H 1 receptor antagonist. [24][25][26] The non-sedating antihistamine drug is extensively prescribed in seasonal allergic rhinitis, chronic urticaria, and other allergic diseases. 26,27 It belongs to biopharmaceutical classification system (BCS) class III, i.e., it has low absorption and high solubility profile.…”

mentioning

confidence: 99%

“…[24][25][26] The non-sedating antihistamine drug is extensively prescribed in seasonal allergic rhinitis, chronic urticaria, and other allergic diseases. 26,27 It belongs to biopharmaceutical classification system (BCS) class III, i.e., it has low absorption and high solubility profile. 13,27 Arefin et al used polymers HPMC K 100 MCR and Eudragit RL 100 to sustain the drug to have better absorption and increased bioavailability.…”

mentioning

confidence: 99%

Evaluation of the Influence of Stirring Speed on the Release Kinetics of Fexofenadine HCl Polymeric Microspheres

Arefin

Habib

Mostafa

et al. 2021

Biosci., Biotech. Res. Asia

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Microspheres, a potential drug delivery approach, has opened a new era for attaining versatile release patterns needed. By optimizing the formulation variables, they can be prepared to obtain targeted release, immediate release, sustained release patterns. The release of the active drug material depends upon a number of formulation parameters such as polymers, stirring speed (rpm), methodology, surfactants, etc. Fexofenadine hydrochloride (HCl) is a second generation antihistamine. Our present research has explored the effects of using different rpm (600- 1000 rpm) in preparing fexofenadine hydrochloride (HCl) microspheres by emulsion solvent evaporation method. The formulation is aimed to provide sustained release for the required long period with a high margin of safety. We used a blended mixture of Hydroxy Propyl Methyl Cellulose (HPMC) K 100 MCR and Eudragit RL100 polymers to have sustained-release microspheres. The impact of different rpm on Yield, drug encapsulation efficiency, flow properties, and dissolution pattern were appraised. We observed the release of the drug for 10 hours in phosphate buffer (pH 6.8) and evaluated the drug release spectrophotometrically. Our study finds that the release of fexofenadine HCl from the microspheres was significantly increased with drug loading. We found the dosage forms to follow Higuchi release kinetics and Hixson-Crowell release kinetics the most, indicating successful achievement of sustained-release pattern in the dosage form. The change in drug release rate was statistically significant for variation in the stirring rate. We found that 600 rpm was the most optimized stirring rate for preparing microspheres in the emulsion solvent evaporation method.

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Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine

Cited by 11 publications

References 51 publications

An overview of microcapsule dosage form

An overview of microcapsule dosage form

Multifaced Role of Dual Herbal Principles Loaded-Lipid Nanocarriers in Providing High Therapeutic Efficacity

Evaluation of the Influence of Stirring Speed on the Release Kinetics of Fexofenadine HCl Polymeric Microspheres

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