Effect of rutin and tannic acid supplements on cholesterol metabolism in rats

Park, Sun Young; Bok, Song Hae; Jeon, Soen Min; Park, Yong Bok; Lee, Soon Jae; Jeong, Tae Sook; Choi, Myung Sook

doi:10.1016/s0271-5317(01)00398-0

Cited by 140 publications

(100 citation statements)

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“…A previous study on the health effects of flavonoids on hypocholesterolemia in chicken fed with 20 mg of rutin per day for 28 days concluded, that rutin reduced the levels of total cholesterol, HDL-cholesterol and LDL-cholesterol (Da Silva et al 2001). The cholesterol-lowering effect of rutin was also observed in rats (Park et al 2002). An in vitro study also concluded that rutin and flavonoid contents in buckwheat had a beneficial effect against lipid peroxidation (Jiang et al 2007).…”

Section: Discussionmentioning

confidence: 86%

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Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Wieslander

Fabjan

Vogrincic

et al. 2011

Tohoku J. Exp. Med.

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Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 ( p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol ( p < 0.001) and HDL-cholesterol ( p < 0.001) during the study period, with improved lung vital capacity ( p < 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.Keywords: antioxidant experiment; buckwheat; cholesterol; inflammation; lung function Tohoku J. Exp. Med., 2011, 225 (2), 123-130. © Tohoku University Medical PressThere is an increased interest in the beneficial health effects of dietary antioxidants intake, because they can help to prevent different types of diseases. Buckwheat is a good source of antioxidants, biologically high-valued amino acids (Krkoškova and Mrazova 2005;Jiang et al. 2007), dietary fiber (Bonafaccia et al. 2003), and minerals such as zinc, copper and manganese (Ikeda and Yamashita 1994). In Shanxi province, China, both common (Fagopyrum esculentum) and tartary (Fagopyrum tataricum) buckwheats are used to improve the health of patients with diabetes and cardiovascular diseases (Wieslander et al. 2000). A previous experimental buckwheat study concluded that intake of common buckwheat leaf tea could prevent further development of leg edema (Ihme et al. 1996), and a study by He et al. (1995) showed a cholesterol-lowering effect of buckwheat. However, there are very few studies on the health effects of buckwheat, especially buckwheat products in humans. Japanese studies indicate that some of the beneficial effects of buckwheat may be related to the low digestibility of buckwheat (Ikeda and Yamashita 1994). Skrabanja et al. (2001) reported beneficial effects of starch in common buckwheat with respect to insulin response. Buckwheat is also a good source of r...

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Section: Discussionmentioning

confidence: 86%

“…Webster et al (1996) showed a protective role of rutin in DNA damage and repair enzymes in rats. Park et al (2002) made a study of effects of rutin and tannic acid supplements on cholesterol metabolism in rats. They observed a lowering effect on plasma and hepatic cholesterol.…”

mentioning

confidence: 99%

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Wieslander

Fabjan

Vogrincic

et al. 2011

Tohoku J. Exp. Med.

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“…Their concentration was measured referring to Park et al [10] assay. Briefly, 200 μL of a 10% (w/v) solution of the tissue homogenate was mixed with 600 μL of distilled H 2 O and 200 μL of 8.1% (w/v) SDS, and then incubated at room temperature for 5 min.…”

Section: Thiobarbituric Acid-reactive Substances (Tbars) Assaymentioning

confidence: 99%

Heart Histopathology and Oxidative Features in Diabetic Rats and Protective Effects of Oleuropein

Jemai¹,

Sayadi²

2015

ABB

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Diabetes induced cardiac dysfunction and lesions are nowadays confirmed. In fact, Diabetes is a chronic metabolic disease, which is associated with oxidative stress and hyperglycaemia which have direct toxic effects on cardio-myocytes. Olive leaves extract compounds, such as Oleuropein, have been used in many therapeutic and preventive cases. The present study is designed to evaluate the effect of Oleuropein as antioxidant on the heart histological and oxidative features in diabetic rats. Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves administration restore significantly the heart histological alteration established by diabetes and enhanced the cardiac antioxidant potential.

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“…As rutin appeared more abundantly than quercetin in buckwheat sprouts, failure in reducing fatty acid synthesis thus was perceivable. Conversely, Park et al (2002) found in rat model that rutin was capable of reducing plasma cholesterol, TGs, and oxidative product levels, although not very effective in suppressing the activity of liver HMG-CoA reductase, yet effectively inhibited the activity of ACAT.…”

Section: Effect Of Alpinia Diets On the Hepatic Lipid Parametersmentioning

confidence: 91%

“…Moreover, AZ contains profound polyphenolics, rutin, and quercetin (Agrawal et al, 2010). Park et al (2002) pointed out that rutin is capable of reducing serum cholesterol, TGs, and oxidative product levels, less effectively suppressed the activity of liver HMG-CoA reductase, yet effectively inhibited the activity of acyl coenzyme A cholesterol acyltransferase (ACAT). Accumulating evidence has revealed that 1,8-cineole, α-terpinene, and γ-terpinene together with the isoflavonoid rutin and quercetin as well as polyphenolics are excellent LDL-C-lowering agents.…”

Section: Effect Of Alpinia Diets On Serum Lipid Levelsmentioning

confidence: 99%