Effect of rutin as flavonoid compound on photodynamic inactivation against P. aeruginosa and S. aureus

Motallebi, Mahroo; Khorsandi, Khatereh; Sepahy, Abbas Akhavan; Chamani, Elham; Hosseinzadeh, Reza

doi:10.1016/j.pdpdt.2020.102074

Cited by 18 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, Liu et al suggested that the paeoniflorin derivative can be used as an antibacterial agent to abolish the hemolytic activity of Staphylococcus aureus a-toxin (36). Motallebi et al highlighted that a combination of rutin and florfenicol could act as an alternative strategy to treat bacterial infections (37). The antibacterial effects of quercetin have been demonstrated in several studies (38,39), and quercetin has even been found to be effective in restoring the intestinal microbiota of mice after antibiotic treatment (40).…”

Section: Discussionmentioning

confidence: 99%

“…Motallebi et al. highlighted that a combination of rutin and florfenicol could act as an alternative strategy to treat bacterial infections ( 37 ). The antibacterial effects of quercetin have been demonstrated in several studies ( 38 , 39 ), and quercetin has even been found to be effective in restoring the intestinal microbiota of mice after antibiotic treatment ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

View full text Add to dashboard Cite

Several studies have investigated the causative role of the microbiome in the development of rheumatoid arthritis (RA), but changes in the gut microbiome in RA patients during drug treatment have been less well studied. Here, we tracked the longitudinal changes in gut bacteria in 22 RA patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX. There were differences in the gut microbiome between untreated (at baseline) RA patients and healthy controls, with 37 species being more abundant in the RA patients and 21 species (including Clostridium celatum) being less abundant. Regarding the functional analysis, vitamin K2 biosynthesis was associated with RA-enriched bacteria. Additionally, in RA patients, alterations in gut microbial species appeared to be associated with RA-related clinical indicators through changing various gut microbiome functional pathways. The clinical efficacy of the two treatments was further observed to be similar, but the response trends of RA-related clinical indices in the two treatment groups differed. For example, HQT treatment affected the erythrocyte sedimentation rate (ESR), while LEF treatment affected the C-reactive protein (CRP) level. Further, 11 species and 9 metabolic pathways significantly changed over time in the HQT group (including C. celatum, which increased), while only 4 species and 2 metabolic pathways significantly changed over time in the LEF group. In summary, we studied the alterations in the gut microbiome of RA patients being treated with HQT or LEF. The results provide useful information on the role of the gut microbiota in the pathogenesis of RA, and they also provide potentially effective directions for developing new RA treatments.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the same sense, some authors have found that rutin shows antibacterial activity against both Gram-positive and Gram-negative bacteria [ 70 , 71 , 72 , 73 ]. Possible mechanisms of action could be related to an increase in the permeability of the bacterial cell wall and cytoplasmic membrane.…”

Section: Resultsmentioning

confidence: 93%

nor 3′-Demethoxyisoguaiacin from Larrea tridentata Is a Potential Alternative against Multidrug-Resistant Bacteria Associated with Bovine Mastitis

et al. 2022

View full text Add to dashboard Cite

Bovine mastitis is one of the most common diseases in dairy cows, and it causes significant economic losses in dairy industries worldwide. Gram-positive and Gram-negative bacteria can cause bovine mastitis, and many of them have developed antimicrobial resistance. There is an urgent need for novel therapeutic options to treat the disease. Larrea tridentata-derived compounds represent an important potential alternative treatment. The aim of the present study was to isolate and characterize antibacterial compounds from Larrea tridentata against multidrug-resistant bacteria associated with bovine mastitis. The L. tridentata hydroalcoholic extract (LTHE) exhibited antibacterial activity. The extract was subjected to a bipartition, giving an aqueous fraction (moderate antibacterial activity) and an organic fraction (higher antibacterial activity). Chromatographic separation of the organic fraction enabled us to obtain four active sub-fractions. Chemical analyses through HPLC techniques were conducted for the LTHE, fractions, and sub-fraction Ltc1-F3, from which we isolated two compounds, characterized by 1H and 13C NMR analyses. Compound nor-3 demethoxyisoguaiacin exhibited the best antibacterial activity against the evaluated bacteria (MIC: 0.01–3.12 mg/mL; MBC: 0.02–3.12 mg/mL). The results indicated that nor-3 demethoxyisoguaiacin can be used as an alternative treatment for multidrug-resistant bacteria associated with mastitis.

show abstract

“…For instance, as typical heat-clearing and damp eliminating herbs, Scutellariae Radix has the main flavonoes of baicalein and baicalin using the direct-acting antibacterial activity to fight against MRSA, S. aureus, and Streptococcus suis infections via inhibition of bacterial membrane functions ( Rajkumari et al, 2017 ; Chen et al, 2018 ; Zhang et al, 2020 ; Lu et al, 2021 ) ( Table 1 ). In addition, other flavonoid compounds in heat-clearing herbs also have the antibacterial abilities of damaging the bacterial membrane, such as quercetin from Gardeniae Fructus (iii, heat-clearing and damp eliminating herb) ( Mohamed et al, 2020 ; Yang et al, 2020 ), kaempferol origin from Moutan Coetrx (ii, heat-clearing and blood-eliminating herb) ( Lin et al, 2020 ; He et al, 2021 ), luteolin and lonicerin from Lonicerae Japonica (iv, heat-clearing and toxin-relieving herb) ( Zhang et al, 2018 ; Singh et al, 2021 ), hyperin and hyperoside origin from Lonicerae Japonica (iv, heat-clearing and toxin-relieving herb) ( Rodrigo Cavalcante de Araújo et al, 2019 ), rutin from Forshiae Fructus (iii, heat-clearing and damp eliminating herb) ( Deepika et al, 2019 ; Di Lodovico et al, 2020 ; Motallebi et al, 2020 ), and mangiferin from Anemarrhenae Rhizome (i, heat-clearing and blood-cooling herbs) ( Tchinda et al, 2019 ). These DAC IM flavonoids that treat bacterial strains are detailed in Table 1 .…”

Section: Modes Of Action Of Flavonoids On Resistant Bacteriamentioning

confidence: 99%

Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria

Song

Ren

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The increasing dissemination of multidrug resistant (MDR) bacterial infections endangers global public health. How to develop effective antibacterial agents against resistant bacteria is becoming one of the most urgent demands to solve the drug resistance crisis. Traditional Chinese medicine (TCM) with multi-target antibacterial actions are emerging as an effective way to combat the antibacterial resistance. Based on the innovative concept of organic wholeness and syndrome differentiation, TCM use in antibacterial therapies is encouraging. Herein, advances on flavonoid compounds of heat-clearing Chinese medicine exhibit their potential for the therapy of resistant bacteria. In this review, we focus on the antibacterial modes of herbal flavonoids. Additionally, we overview the targets of flavonoid compounds and divide them into direct-acting antibacterial compounds (DACs) and host-acting antibacterial compounds (HACs) based on their modes of action. We also discuss the associated functional groups of flavonoid compounds and highlight recent pharmacological activities against diverse resistant bacteria to provide the candidate drugs for the clinical infection.

show abstract

Effect of rutin as flavonoid compound on photodynamic inactivation against P. aeruginosa and S. aureus

Cited by 18 publications

References 31 publications

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis

nor 3′-Demethoxyisoguaiacin from Larrea tridentata Is a Potential Alternative against Multidrug-Resistant Bacteria Associated with Bovine Mastitis

Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria

Contact Info

Product

Resources

About