Effect of Ruzu Herbal Bitters on the Liver Function and Lipid Profile Parameters of Alloxan-Induced Diabetic Rats

Obasi, David C.; Ogugua, Victor N.

doi:10.1016/j.jceh.2021.09.012

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…It leads to the deposition of lipid on the arterial wall, thereby aggravating the process of atherosclerosis 55 and is associated with high TC, TG, LDL, with low HDL levels in plasma 56,57 . Several studies have reported increased levels of serum TC, TG and LDL, with decreased levels of HDL in coronary heart disease 58,59 and diabetic patients 60 . The medicinal activities of U. chamae have been attributed to its various phytochemical constituents 15 .…”

Section: Discussionmentioning

confidence: 99%

Uvaria chamae Stem Extracts Possess Nephroprotective and Cardioprotective Effects Against Carbon Tetrachloride-Induced Toxicity in Albino Rats

Obas,

Obasi,

Agbafo

2023

Asian J. Biol. Sci

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Background and Objective: Renal and cardiovascular diseases are among the leading causes of death worldwide and require alternative medical interventions. This study investigated the effects of deionized water and ethyl acetate extracts of Uvaria chamae stem (DEEUS) on renal and cardiovascular parameters of carbon tetrachloride (CCl 4 )-induced toxicity in albino rats. Materials and Methods: A total of 54 male albino rats were divided into 9 groups of 6 rats each. Group 1 served as normal control. Groups 2-9 were injected with CCl 4 . Group 2 was untreated, group 3 received 20 mg kgG 1 b.wt., of vitamin C, while groups 4-9 were treated with DEEUS at doses of 200, 400 and 600 mg kgG 1 b.wt., respectively for 21 days via oral intubation. The renal and cardiovascular parameters of these rats were determined. The data obtained from the biochemical tests were subjected to a One-way Analysis of Variance (ANOVA). Results: There were significantly (p<0.05) higher concentrations of serum urea, creatinine, uric acid, sodium, potassium, bicarbonate, cTnI, TG, TC and LDL, with lower concentrations of HDL, as well as significant (p<0.05) higher activities of CK and LDH in the untreated group compared to the normal control. Upon treatment, the extracts prevented further tissue damage, leading to the recovery of the animals as shown by the differences between the treated and untreated groups. The effects were found to be dosedependent, with higher effects observed in the ethyl acetate extract than in the deionized water extract. Conclusion: The results indicated that Uvaria chamae stem extracts possess nephroprotective and cardioprotective activities and could be harnessed for the management of renal and cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Uvaria chamae Stem Extracts Possess Nephroprotective and Cardioprotective Effects Against Carbon Tetrachloride-Induced Toxicity in Albino Rats

Obas,

Obasi,

Agbafo

2023

Asian J. Biol. Sci

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Effect of Orijin Bitters, Aqueous Extracts of Hibiscus Sabdariffa and Zingiber Officinale Roscoe on the Kidney of Adult Wistar Rats

David,

Duru,

Abraham

et al. 2024

IJMSS

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Orijin bitters, Hibiscus sabdariffa and Zingiber officinale roscoe have been reported to possess various medicinal properties. The aim of the study is to evaluate their effects on the kidney of adult wistar rats. Methodology: thirty rats were randomly divided into 6 groups, each having 5 rats. Group 1 received distilled water, group 2, 70cl/70kg/bw orijin bitters, group 3, orijin bitters and 200mg/kg/bw Hibiscus sabdariffa calyx aqueous extract, group 4, orijin bitters and 500mg/kg/bw Hibiscus sabdariffa calyx aqueous extract, group 5, orijin bitters and 200mg/kg/bw officinale rhizome aqueous extract, group 6, orijin bitters and 500mg/kg/bw Zingiber officinale rhizome aqueous extract over a 21- day period. After administration, the rats were sacrificed and the kidney harvested for biochemical and histological analysis. Results: Orijin bitters altered renal function, indicated by elevated level of malondialdehyde and decreased level of superoxide dismutase, catalase and glutathione, along with histopathological changes such as glomerular atrophy and tubular degeneration compared to the control. The result was not statistically significant (P < 0.05). Conversely, aqueous extracts of Hibiscus sabdariffa calyx and Zingiber officinale rhizome exhibited antioxidant properties, reducing oxidative stress and mitigating renal damage compared to the orijin bitters group only. Although the result was not statistically significant (P < 0.05). Conclusion: Orijin bitters may have nephrotoxic effects, while Hibiscus sabdariffa and Zingiber officinale may offer protective benefits, due to their antioxidant properties.

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Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats

Aldayel,

Kilany,

El-Hak

et al. 2024

Life

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Doxorubicin (DOX) cancer therapy induces serious cardiotoxicity as a side effect. This study aimed to investigate the cardioprotective effects of grape seed extract (GSE) and L-Carnitine (L-CA) against DOX-induced cardiac toxicity in male rats. Six groups of male albino rats were used: G1 (control); G2 (GSE), given grape seed extract (100 mg/kg b.wt.) orally for 35 days; G3 (L-CA) (150 mg/kg b.wt.); Group 4 (DOX-induced cardiotoxicity), given DOX (10 mg/kg b.wt., i.p.) on the 28th day of the experiment; G5 (GSE + DOX), given GSE and DOX as previously mentioned; and G6 (L-CA + DOX), given L-CA and DOX as previously mentioned. Electrocardiographic evaluation, lipid profile, lipid peroxidation and antioxidants, serum cardiac markers, and inflammatory markers were estimated. Histopathological evaluation of cardiac tissue was also examined. Key findings showed that DOX induced ECG abnormalities lipid peroxidation, reduced antioxidants, and elevated cardiac and inflammatory markers. GSE and L-CA significantly ameliorated ECG abnormalities, reduced lipid peroxidation, improved antioxidant enzymes and serum cardiac markers, and reduced inflammation. These findings suggest that GSE and L-CA exhibit substantial cardioprotective effects in DOX-induced cardiotoxicity via their antioxidant and anti-inflammatory potentials.

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Effect of Ruzu Herbal Bitters on the Liver Function and Lipid Profile Parameters of Alloxan-Induced Diabetic Rats

Cited by 3 publications

References 22 publications

Uvaria chamae Stem Extracts Possess Nephroprotective and Cardioprotective Effects Against Carbon Tetrachloride-Induced Toxicity in Albino Rats

Uvaria chamae Stem Extracts Possess Nephroprotective and Cardioprotective Effects Against Carbon Tetrachloride-Induced Toxicity in Albino Rats

Effect of Orijin Bitters, Aqueous Extracts of Hibiscus Sabdariffa and Zingiber Officinale Roscoe on the Kidney of Adult Wistar Rats

Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats

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